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Bruce M. Spiegelman
Researcher at Harvard University
Publications - 443
Citations - 172265
Bruce M. Spiegelman is an academic researcher from Harvard University. The author has contributed to research in topics: Adipose tissue & Transcription factor. The author has an hindex of 179, co-authored 434 publications receiving 158009 citations. Previous affiliations of Bruce M. Spiegelman include University of California, San Francisco & Vassar College.
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Journal ArticleDOI
Degradation of the Peroxisome Proliferator-activated Receptor γ Is Linked to Ligand-dependent Activation
Stefanie Hauser,Guillaume Adelmant,Pasha Sarraf,Harold M. Wright,Elisabetta Mueller,Bruce M. Spiegelman +5 more
TL;DR: It is reported that PPARγ protein levels are significantly reduced in adipose cells and fibroblasts in response to specific ligands such as thiazolidinediones.
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The Transcriptional Coactivator PGC-1β Drives the Formation of Oxidative Type IIX Fibers in Skeletal Muscle
Zoltan Arany,Nathan K. LeBrasseur,Carl Morris,Eric E. Smith,Wenli Yang,Yanhong Ma,Sherry Chin,Bruce M. Spiegelman +7 more
TL;DR: It is shown that transgenic expression of PGC-1beta causes a marked induction of IIX fibers, which are oxidative but have "fast-twitch" biophysical properties and are rich in mitochondria and are highly oxidative, at least in part due to coactivation by P GC-1 beta of ERRalpha and PPARalpha.
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C/EBPβ controls exercise-induced cardiac growth and protects against pathological cardiac remodeling
Pontus Boström,Nina Mann,Jun Wu,Pablo A. Quintero,Eva Plovie,Daniela Panáková,Rana K. Gupta,Chunyang Xiao,Calum A. MacRae,Anthony Rosenzweig,Bruce M. Spiegelman +10 more
TL;DR: Data indicate that C/EBPβ represses cardiomyocyte growth and proliferation in the adult mammalian heart and that reduction in C/ EBPβ is a central signal in physiologic hypertrophy and proliferation.
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c-fos is required for malignant progression of skin tumors
Enrique Saez,Susan E. Rutberg,Elisabetta Mueller,Heather Oppenheim,Jennifer Smoluk,Stuart H. Yuspa,Bruce M. Spiegelman +6 more
TL;DR: Experiments in which v-H-ras-expressing keratinocytes were grafted onto nude mice suggest that c-fos-deficient cells have an intrinsic defect that hinders tumorigenesis.
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Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-γ coactivator 1α
Zoltan Arany,Mikhail S. Novikov,Sherry Chin,Yanhong Ma,Anthony Rosenzweig,Bruce M. Spiegelman +5 more
TL;DR: It is shown that TAC in mice genetically engineered to lack PGC-1alpha leads to accelerated cardiac dysfunction, which is accompanied by signs of significant clinical heart failure, and the data suggest that elevating P GC-1 alpha activity may have therapeutic potential in the treatment of heart failure.