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Bruce M. Spiegelman
Researcher at Harvard University
Publications - 443
Citations - 172265
Bruce M. Spiegelman is an academic researcher from Harvard University. The author has contributed to research in topics: Adipose tissue & Transcription factor. The author has an hindex of 179, co-authored 434 publications receiving 158009 citations. Previous affiliations of Bruce M. Spiegelman include University of California, San Francisco & Vassar College.
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BookDOI
Hormones, Metabolism and the Benefits of Exercise
TL;DR: This open access volume focuses on the cellular and molecular pathways that link exercise, muscle biology, hormones and metabolism, and will include novel “myokines” that might act as new therapeutic agents in the future.
Journal ArticleDOI
A Plasma Protein Network Regulates PM20D1 and N-Acyl Amino Acid Bioactivity.
Joon T. Kim,Mark P. Jedrychowski,Wei Wei,Daniel Fernández,Curt R. Fischer,Steven M. Banik,Bruce M. Spiegelman,Jonathan Z. Long +7 more
TL;DR: It is shown that PM20D1 circulates in tight association with both low- and high-density lipoproteins, and a lipoprotein-albumin network that regulates the activity of a circulating thermogenic lipid family is identified.
Journal ArticleDOI
Reduced adipsin mRNA and circulating adipsin protein are modulated by adrenal steroids in obese Zucker rats
TL;DR: The data suggest that adrenal steroids are involved in modulating adipsin expression in obese Zucker rats and that insulin may be an intermediary factor in such modulation.
Journal Article
Corrigendum: Targeted expression of Cre recombinase to adipose tissue of transgenic mice directs adipose-specific excision of loxP-flanked gene segments (Nucleic Acids Research (1997) 25 (2543-2545))
Carrolee Barlow,M. Schroeder,Julie A. Lekstrom-Himes,Helen Kylefjord,Chu-Xia Deng,Anthony Wynshaw-Boris,Bruce M. Spiegelman,Kleanthis G. Xanthopoulos +7 more
Journal ArticleDOI
Tumor necrosis factor-α as a mediator of the insulin resistance of obesity
TL;DR: Evidence has accumulated that implicates the cytokine tumor necrosis factor-α (TNF-α) as a significant contributor to this pathophysiological associative mechanism of obesity.