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Bruce M. Spiegelman
Researcher at Harvard University
Publications - 443
Citations - 172265
Bruce M. Spiegelman is an academic researcher from Harvard University. The author has contributed to research in topics: Adipose tissue & Transcription factor. The author has an hindex of 179, co-authored 434 publications receiving 158009 citations. Previous affiliations of Bruce M. Spiegelman include University of California, San Francisco & Vassar College.
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Journal ArticleDOI
Activation of PPARγ coactivator-1 through transcription factor docking
Pere Puigserver,Guillaume Adelmant,Zhidan Wu,Melina Fan,Jianming Xu,Bert W. O'Malley,Bruce M. Spiegelman +6 more
TL;DR: PGC-1 promotes transcription through the assembly of a complex that includes the histone acetyltransferases steroid receptor coactivator-1 (SRC-1) and CREB binding protein (CBP)/p300, resulting in a large increase in transcriptional activity.
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ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation.
TL;DR: The screening of an adipocyte cDNA expression library suggests that ADD1 plays a role in the regulation of determination- and differentiation-specific gene expression in adipocytes.
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Common DNA binding site for Fos protein complexesand transcription factor AP-1
TL;DR: It is shown that there is a dramatic increase in the FSE2 binding complex when Fos levels are induced with serum, benzodiazepine, and nerve growth factor or are expressed from a v-fos gene, suggesting a functional relationship between Fos and AP-1.
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A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat
Lawrence Kazak,Edward T. Chouchani,Mark P. Jedrychowski,Brian K. Erickson,Kosaku Shinoda,Paul Cohen,Ramalingam Vetrivelan,Gina Z. Lu,Dina Laznik-Bogoslavski,Sebastian C. Hasenfuss,Shingo Kajimura,Steve P. Gygi,Bruce M. Spiegelman +12 more
TL;DR: It is demonstrated that creatine enhances respiration in beige-fat mitochondria when ADP is limiting and decreases whole-body energy expenditure after administration of a β3-agonist and reduces beige and brown adipose metabolic rate.
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Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity.
TL;DR: The results suggest that UCP synthesized from the aP2 gene promoter is thermogenically active and capable of reducing fat stores.