Bruce M. Spiegelman

TL;DR: Adipose cells are the principal site for the storage of energy in the form of triglycerides in vertebrates and proteins related to the products of the fos and jun oncogenes have been implicated as transacting factors in the differentiation-dependent control of fat cell gene expression.

TL;DR: In this article, the authors identify isthmin-1 (Ism1) as an adipokine and one that has a dual role in increasing adipose glucose uptake while suppressing hepatic lipid synthesis.

TL;DR: Results indicate that 950 bases of the 5' flanking region of the adipsin gene carry information that specifies both expression in adipose tissue and a response to a gene or chemical that induces obesity, and suggest that the trans-acting factors that are regulated aberrantly in these forms of obesity are not restricted to adipOSE tissue and could play a role in obesity-linked dysfunctions observed in other tissues as well.

TL;DR: Results indicate that a tissue-specific transcription factor(s) that regulates adipsin expression is less active in the adipose tissue of obese animals.

TL;DR: In this article, the authors describe methods for inhibiting proliferation of a PPAR-responsive hyperproliferative cell using PPARη agonists and pharmaceutical compositions as well as methods for diagnosing and treating such cells.