Showing papers by "Claire M. Healy published in 2011"
International Agency for Research on Cancer1, Russian Academy2, Nofer Institute of Occupational Medicine3, Curie Institute4, Charles University in Prague5, National and Kapodistrian University of Athens6, Harvard University7, Institut Gustave Roussy8, University of Bremen9, University of Turin10, University of Aberdeen11, University of Padua12, Imperial College London13, Newcastle University14, Glasgow Dental Hospital and School15, National Health Service16, Trinity College, Dublin17, Oswaldo Cruz Foundation18, Universidade Federal de Pelotas19, University of São Paulo20, Catholic University of the Sacred Heart21, University of North Carolina at Chapel Hill22, Pomeranian Medical University23, Fred Hutchinson Cancer Research Center24, Pennsylvania State University25, University of California, Los Angeles26, University of Texas MD Anderson Cancer Center27, Brown University28, Boston University29, University of Minnesota30, University of Pittsburgh31, Maastricht University32, Radboud University Nijmegen33, University of Toronto34, Cancer Care Ontario35, Norwegian University of Science and Technology36, University of Liverpool37, University of Naples Federico II38, University of Cambridge39, University of Oxford40, Utrecht University41, German Cancer Research Center42, Umeå University43, Aarhus University44, University Hospital of North Norway45, University of Tartu46, University of Paris47, New York University48
TL;DR: A genome-wide association study to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers implicate two variants at 4q21 and 12q24 and further highlight three ADH variants in UADT cancer susceptibility.
Abstract: Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers. Genome-wide genotyping was carried out using the Illumina HumanHap300 beadchips in 2,091 UADT cancer cases and 3,513 controls from two large European multi-centre UADT cancer studies, as well as 4,821 generic controls. The 19 top-ranked variants were investigated further in an additional 6,514 UADT cancer cases and 7,892 controls of European descent from an additional 13 UADT cancer studies participating in the INHANCE consortium. Five common variants presented evidence for significant association in the combined analysis (p≤5×10−7). Two novel variants were identified, a 4q21 variant (rs1494961, p = 1×10−8) located near DNA repair related genes HEL308 and FAM175A (or Abraxas) and a 12q24 variant (rs4767364, p = 2×10−8) located in an extended linkage disequilibrium region that contains multiple genes including the aldehyde dehydrogenase 2 (ALDH2) gene. Three remaining variants are located in the ADH gene cluster and were identified previously in a candidate gene study involving some of these samples. The association between these three variants and UADT cancers was independently replicated in 5,092 UADT cancer cases and 6,794 controls non-overlapping samples presented here (rs1573496-ADH7, p = 5×10−8; rs1229984-ADH1B, p = 7×10−9; and rs698-ADH1C, p = 0.02). These results implicate two variants at 4q21 and 12q24 and further highlight three ADH variants in UADT cancer susceptibility.
308 citations
International Agency for Research on Cancer1, University of Mainz2, National and Kapodistrian University of Athens3, University of Bremen4, Charles University in Prague5, University of Turin6, University of Aberdeen7, University of Manchester8, University of Padua9, Imperial College London10, University of Glasgow11, National Health Service12, University of Leeds13, Newcastle University14, Trinity College, Dublin15, Royal College of Surgeons in Ireland16, University of Utah17
TL;DR: While the majority of the UADT cancers in Europe are due to tobacco or the joint effect of tobacco and alcohol, the results support a significant role for other risk factors in particular, for oral and oropharyngeal cancers and also for UADt cancers in southern and western Europe.
143 citations
TL;DR: The demographics, symptoms, clinical features and laboratory findings in a large cohort of cases of orofacial granulomatosis patients, one of the largest cohorts to have been described in detail, are described.
Abstract: Oral Diseases (2011) 17, 696–704
Objectives: Orofacial granulomatosis has mostly been described in reports of very small numbers of cases. Few large case groups have been described. The aim of this study was to describe the demographics, symptoms, clinical features and laboratory findings in a large cohort of cases.
Subjects and Methods: Clinical and laboratory data for 119 cases of orofacial granulomatosis who attended oral medicine clinics in Dublin, Ireland, were examined for demographic characteristics at the time of first presentation. The male/female ratio was approximately 1:1, with a median age (and range) of 28 (5–84) years.
Results: Symptoms had been present for a median duration of 12 weeks. A food association was suspected by 30% of patients. The predominant complaint was lip swelling (77%) with only 15% reporting facial swelling, while 8% complained of both. Almost all patients had clinical evidence of lip or facial swelling (95%). Other common extra-oral manifestations were lip fissuring (30%), angular cheilitis (28%) and perioral erythema (28%). Common intra-oral manifestations were cobblestoning of the buccal mucosa (63%), ulcers (36%), granulomatous gingivitis (33%), mucosal tags (29%) and fissured tongue (17%). Over half of the biopsies (56%) performed were reported as typical of orofacial granulomatosis.
Conclusion: This is one of the largest cohorts of orofacial granulomatosis patients to have been described in detail.
68 citations
TL;DR: Both standard and urticarial patch tests are required to detect food allergies in orofacial granulomatosis and the difficulties of patient self-recording of urticaria tests can be eliminated by retaining patients in the testing unit for professional reading of patches at 60 min.
Abstract: J Oral Pathol Med (2011) 40: 10–13
Background: Food-associated allergies, especially to benzoates and cinnamon-related compounds, have been associated with orofacial granulomatosis and both standard and urticarial patch testing have been used to detect such allergies. Elimination diets have also been shown to be effective in some patients.
Objectives: To compare the results of standard and urticarial patch testing in a cohort of patients with orofacial granulomatosis.
Materials and methods: Records of 120 cases seen in two hospitals were retrieved and examined for patch test details.
Results: Standard patch testing was much less likely to detect allergy to benzoates and cinnamon compounds (7%) than urticarial tests (55%). All urticarial tests that were positive had shown a reaction by 60 min.
Conclusions: Both standard and urticarial patch tests are required to detect food allergies in orofacial granulomatosis. The difficulties of patient self-recording of urticarial tests can be eliminated by retaining patients in the testing unit for professional reading of patches at 60 min.
40 citations
University of California, Los Angeles1, University of Utah2, International Agency for Research on Cancer3, University of Barcelona4, University of Bremen5, Charles University in Prague6, French Institute of Health and Medical Research7, Institut Gustave Roussy8, University of Padua9, Trinity College, Dublin10, National and Kapodistrian University of Athens11, Newcastle University12, University of Aberdeen13, Royal College of Surgeons in Ireland14, University of Leeds15, University of Turin16, Harvard University17
TL;DR: BMI gain is inversely associated with UADT cancers, and these findings may be influenced by smoking and/or drinking behaviors and/ or the development of preclinical UadT cancers and should be corroborated in studies of a prospective nature.
Abstract: Previous studies reported an inverse relationship between body mass index (BMI) and upper aerodigestive tract (UADT) cancers. Examining change in BMI over time may clarify these previous observations. We used data from 2,048 cases and 2,173 hospital- and population-based controls from ten European countries (alcohol-related cancers and genetic susceptibility in Europe study) to investigate the relationship with BMI and adult change in BMI on UADT cancer risk. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for associations between BMI at three time intervals and BMI change on UADT cancer development, adjusting for center, age, sex, education, fruit and vegetable intake, smoking and alcohol consumption. We found an inverse relationship between UADT cancers and BMI at time of interview and 2 years before interview. No association was found with BMI at 30 years of age. Regarding BMI change between age 30 and 2 years before interview, BMI decrease (BMI change <-5%) vs. BMI stability (-5% ≤ BMI change <5%) showed no overall association with UADT cancers (OR = 1.15; 95% CI = 0.89, 1.49). An increase in BMI (BMI change ≥+5%) was inversely associated with UADT cancers (OR = 0.74; 95% CI = 0.62, 0.89). BMI gain remained inversely associated across all subsites except for esophageal cancer. When stratified by smoking or by drinking, association with BMI gain was detected only in drinkers and smokers. In conclusion, BMI gain is inversely associated with UADT cancers. These findings may be influenced by smoking and/or drinking behaviors and/or the development of preclinical UADT cancers and should be corroborated in studies of a prospective nature.
25 citations
TL;DR: The findings suggest that alternative Candida treatment options, other than azoles such as chlorhexidine, should be considered in APECED patients and that clinical diagnosis of oral candidiasis should be confirmed by culture prior to the commencement of anti-Candida therapy.
Abstract: Patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) are prone to chronic mucocutaneous candidiasis, which is often treated with azoles. The purpose of this study was to characterize the oral Candida populations from 16 Irish APECED patients, who comprise approximately half the total number identified in Ireland, and to examine the effect of intermittent antifungal therapy on the azole susceptibility patterns of Candida isolates. Patients attended between one and four clinical evaluations over a 5-year period, providing oral rinses and/or oral swab samples each time. Candida was recovered from 14/16 patients, and Candida albicans was the only Candida species identified. Interestingly, clinical diagnosis of candidiasis did not correlate with microbiological evidence of Candida infection at 7/22 (32%) clinical assessments. Multilocus sequence typing analysis of C. albicans isolates recovered from the same patients on separate occasions identified the same sequence type each time. Fluconazole resistance was detected in isolates from one patient, and isolates exhibiting a progressive reduction in itraconazole and/or fluconazole susceptibility were identified in a further 3/16 patients, in each case correlating with the upregulation of CDR- and MDR-encoded efflux pumps. Mutations were also identified in the ERG11 and the TAC1 genes of isolates from these four patients; some of these mutations have previously been associated with azole resistance. The findings suggest that alternative Candida treatment options, other than azoles such as chlorhexidine, should be considered in APECED patients and that clinical diagnosis of oral candidiasis should be confirmed by culture prior to the commencement of anti-Candida therapy.
23 citations
International Agency for Research on Cancer1, University of North Carolina at Chapel Hill2, University of Pittsburgh3, Brown University4, Boston University5, Maastricht University6, Radboud University Nijmegen7, Pomeranian Medical University8, Pennsylvania State University9, University of Texas MD Anderson Cancer Center10, University of California, Los Angeles11, Fred Hutchinson Cancer Research Center12, Institut Gustave Roussy13, French Institute of Health and Medical Research14, National and Kapodistrian University of Athens15, Charles University in Prague16, University of Turin17, University of Aberdeen18, Medical Research Council19, University of Manchester20, Glasgow Dental Hospital and School21, Trinity College, Dublin22, University of Bremen23, Nofer Institute of Occupational Medicine24, Curie Institute25, Universidade Federal de Pelotas26, University of São Paulo27, Catholic University of the Sacred Heart28, University of Utah29, New York University30, Icahn School of Medicine at Mount Sinai31
TL;DR: A sex difference in the association between the 15q25 variant rs16969968 and UADT cancers is confirmed and further research is warranted to elucidate the mechanisms underlying these observations.
Abstract: Background: Sequence variants located at 15q25 have been associated with lung cancer and propensity to smoke. We recently reported an association between rs16969968 and risk of upper aerodigestive tract (UADT) cancers (oral cavity, oropharynx, hypopharynx, larynx and esophagus) in women (odds ratio (OR) =1.24, P=0.003) with little effect in men (OR=1.04, P=0.35).
Methods: In a coordinated genotyping study within the International Head and Neck Cancer Epidemiology (INHANCE) consortium, we have sought to replicate these findings in an additional 4,604 cases and 6,239 controls from 10 independent UADT cancer case-control studies.
Results: rs16969968 was again associated with UADT cancers in women (OR=1.21, 95% confidence interval(CI)=1.08-1.36, P=0.001) and a similar lack of observed effect in men (OR=1.02, 95%CI=0.95-1.09, P=0.66) (P-heterogeneity=0.01). In a pooled analysis of the original and current studies, totaling 8,572 UADT cancer cases and 11,558 controls, the association was observed among females (OR=1.22, 95%CI=1.12-1.34, P=7x10-6) but not males (OR=1.02, 95%CI=0.97-1.08, P=0.35) (P-heterogeneity=6x10-4). There was little evidence for a sex difference in the association between this variant and cigarettes smoked per day, with male and female rs16969968 variant carriers smoking approximately the same amount more in the 11,991 ever smokers in the pooled analysis of the 14 studies (P-heterogeneity=0.86).
Conclusions: This study has confirmed a sex difference in the association between the 15q25 variant rs16969968 and UADT cancers.
Impact: Further research is warranted to elucidate the mechanisms underlying these observations.
20 citations
Imperial College London1, International Agency for Research on Cancer2, University of Barcelona3, University of Bremen4, French Institute of Health and Medical Research5, Catholic University of the Sacred Heart6, Fred Hutchinson Cancer Research Center7, University of Glasgow8, New York University9, Trinity College, Dublin10, Charles University in Prague11, National and Kapodistrian University of Athens12, Pennsylvania State University13, University of Aberdeen14, University of Turin15, Estonian Biocentre16, University of Michigan17, University of North Carolina at Chapel Hill18, National Institutes of Health19, Heidelberg University20, University of Padua21, University of Iowa22, University of Texas MD Anderson Cancer Center23, Nofer Institute of Occupational Medicine24, Newcastle University25, Russian Academy26, University of California, Los Angeles27, University of Utah28
TL;DR: No functional study currently supports the observed association for MGMT Leu84Phe, and the association with XRCC1 Arg194Trp may be a chance finding, but associations between ADH1B Arg48His,ADH1C Ile350Arg, and GSTM1 null genotype and head and neck cancer risk are observed.
Abstract: Previous molecular epidemiological studies on head and neck cancer have examined various single nucleotide polymorphisms, but there are very few documented associations. In the International Head and Neck Cancer Epidemiology (INHANCE) consortium, we evaluated associations between SNPs in the metabolism, cell cycle, and DNA repair pathways and the risk of head and neck cancer. We analyzed individual-level pooled data from 14 European, North American, Central American and Asia case-control studies (5,915 head and neck cancer cases and 10,644 controls) participating in the INHANCE consortium. Unconditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for SNP effects, adjusting for age, sex, race, and country. We observed an association between head and neck cancer risk and MGMT Leu84Phe heterozygotes (OR=0.79, 95% CI=0.68-0.93), XRCC1 Arg194Trp rare homozygotes (OR=2.3, 95% CI=1.1-4.7), ADH1B Arg48His homozygotes Arg/Arg (OR=2.7, 95% CI=1.9-4.0), ADH1C Ile350Val homozygotes Ile/Ile (OR=1.2, 95% CI=1.1-1.4), and the GSTM1 null genotype (OR=1.1, 95% CI=1.0-1.2). Among these results, MGMT Leu84Phe, ADH1B Arg48His, ADH1C Ile350Arg, and the GSTM1 null genotype had fairly low false positive report probabilities (<20%). We observed associations between ADH1B Arg48His, ADH1C Ile350Arg, and GSTM1 null genotype and head and neck cancer risk. No functional study currently supports the observed association for MGMT Leu84Phe, and the association with XRCC1 Arg194Trp may be a chance finding.
19 citations
Journal Article•
TL;DR: An examination protocol is suggested here, which is similar to, but more detailed than, the standardised oral examination method recommended by the World Health Organisation, and consistent with those protocols followed by the Centres for Disease Control and Prevention and the National Institutes of Health.
Abstract: Cancer of the head and neck region presents a challenge since, unlike other areas of the body, the boundaries are not always easy to delineate. The functional morbidity associated with head and neck cancer and its treatment are considerable. Head and neck cancer is described as cancer of the lip, mouth, tongue, tonsil, pharynx (unspecified), salivary gland, hypopharynx, larynx and other. Oral cancer refers to cancers of the lip, tongue, gingivae, floor of the mouth, palate (hard and soft), maxilla, vestibule and retromolar area up to the anterior pillar of the fauces (tonsil). When patients present with oral cancer, over 60% of them have regional (lymph node) and sometimes distant (metastatic) spread. The overall five-year survival rates for oral cancer average at between 50 and 80%, depending on the stage of the disease, varying from 86% for stage I to 12-16% for stage IV. The incidence of 'field cancerisation'/unstable oral epithelium is high (17%), and even after successful treatment our patients need to be monitored for dental care and further disease. Unlike other areas in the body, the oral epithelium is readily accessible for examination and even self-examination. Dentists and dental hygienists are effective clinicians in the examination of the oral cavity for mouth cancer. An oral and neck examination must be part of every dental examination. An examination protocol is suggested here, which is similar to, but more detailed than, the standardised oral examination method recommended by the World Health Organisation, and consistent with those protocols followed by the Centres for Disease Control and Prevention and the National Institutes of Health.
15 citations
University of Leeds1, Cardiff University2, University of Birmingham3, University of Bristol4, University College Cork5, University College Dublin6, University of Dundee7, Glasgow Dental Hospital and School8, University of Liverpool9, University of Manchester10, North Manchester General Hospital11, University of London12, Queen Mary University of London13, University of Newcastle14, University of Sheffield15, Peninsula College of Medicine and Dentistry16, University of Central Lancashire17, Queen's University Belfast18
TL;DR: The consensus curriculum for undergraduate Clinical Medical Sciences in Dentistry teaching agreed by the participating centres is reported and it includes elements that are likely to be applicable to others.
Abstract: The technical aspects of dentistry need to be practised with insight into the spectrum of human diseases and illnesses and how these impact upon individuals and society. Application of this insight is critical to decision-making related to the planning and delivery of safe and appropriate patient-centred healthcare tailored to the needs of the individual. Provision for the necessary training is included in undergraduate programmes, but in the United Kingdom and Ireland there is considerable variation between centres without common outcomes. In 2009 representatives from 17 undergraduate dental schools in the United Kingdom and Ireland agreed to move towards a common, shared approach to meet their own immediate needs and that might also be of value to others in keeping with the Bologna Process. To provide a clear identity the term 'Clinical Medical Sciences in Dentistry' was agreed in preference to other names such as 'Human Disease' or 'Medicine and Surgery'. The group was challenged to define consensus outcomes. Contemporary dental education documents informed, but did not drive the process. The consensus curriculum for undergraduate Clinical Medical Sciences in Dentistry teaching agreed by the participating centres is reported. Many of the issues are generic and it includes elements that are likely to be applicable to others. This document will act as a focus for a more unified approach to the outcomes required by graduates of the participating centres and act as a catalyst for future developments that ultimately aim to enhance the quality of patient care.
11 citations
Journal Article•
TL;DR: It is incumbent on the clinician/dentist to evaluate each patient’s general health prior to delivering treatment in order to avoid unnecessary and preventable complications.
Abstract: In everyday practice, dentists are confronted with an increasing number of patients with complex medical problems. There is divergence of opinion among dentists regarding how to obtain a thorough medical/social history. Purpose: The objective of this audit is to produce a standardised medical history in order to identify the medically compromised patient attending the general dental practitioner. At present in the Dublin Dental School and Hospital, there are three different methods: a verbal enquiry, and a written or an electronic questionnaire. This study was undertaken to identify any differences or discrepancies between each of the three methods in eliciting the medical history, and to determine whether one method was superior to the others. The results are used to recommend the most accurate method for obtaining a thorough health history for practitioners, both in a hospital and a general practice setting. Method: One hundred and fifty charts within the Dublin Dental School and Hospital of all new patients at a randomly chosen clinic were selected and then audited: 50 charts from the oral and maxillofacial surgery assessment clinics (written pro forma questionnaire), 50 from the oral medicine clinic (consultant verbal enquiry), and 50 from A&E (electronic questionnaire) were compared to determine if an adequate medical history was taken, and to detect differences and discrepancies in patients’ medical histories. The records pertained to 91 females and 59 males. The age distribution was 5-87 years for females and 3-85 years for males. The mean age was 45 years for females and 42 years for males. Results: The written patient-administered pro forma questionnaire, combined with verbal verification by the clinician/consultant, proved to be the most useful and consistent method for detecting medical problems in dental patients. The consultant verbal enquiry alone showed more inconsistency than the other two methods. Based on these results, a modified questionnaire for use within all departments in the Dental Hospital has been proposed. This may also be suitable for use by general dental practitioners in their practice setting. Conclusion: It is incumbent on the clinician/dentist to evaluate each patient’s general health prior to delivering treatment in order to avoid unnecessary and preventable complications. The use of written patient-administered pro forma questionnaires is beneficial but must be verified by the examining clinician/dentist and assessed at each new visit (6-12 monthly) to be contemporaneous. Journal of the Irish Dental Association 2011; 57 (1): 54-59. February/March 2011 54 : VOLUME 57 (1) Peer-reviewed JOURNAL OF THE IRISH DENTAL ASSOCIATION JIDA_FebruaryMarch2011_AW_JIDA 07/02/2011 10:30 Page 54
01 Jan 2011
TL;DR: There was little evidence for a sex difference in the association between this variant and cigarettes smoked per day, with male and female rs16969968 variant carriers smoking approximately the same amount more in the 11,991 ever smokers in the pooled analysis of the 14 studies.
Abstract: Background: Sequence variants located at 15q25 have been associated with lung cancer and propensity to smoke. We recently reported an association between rs16969968 and risk of upper aerodigestive tract (UADT) cancers (oral cavity, oropharynx, hypopharynx, larynx, and esophagus) in women (OR1⁄4 1.24, P1⁄4 0.003) with little effect in men (OR 1⁄4 1.04, P 1⁄4 0.35). Methods: In a coordinated genotyping study within the International Head and Neck Cancer Epidemiology (INHANCE) consortium, we have sought to replicate these findings in an additional 4,604 cases and 6,239 controls from 10 independent UADT cancer case–control studies. Results: rs16969968was again associatedwithUADT cancers inwomen (OR1⁄4 1.21, 95%CI1⁄4 1.08–1.36, P1⁄4 0.001) and a similar lack of observed effect in men [OR 1⁄4 1.02, 95% CI 1⁄4 0.95–1.09, P 1⁄4 0.66; P-heterogeneity (Phet) 1⁄4 0.01]. In a pooled analysis of the original and current studies, totaling 8,572 UADT cancer cases and 11,558 controls, the association was observed among females (OR1⁄4 1.22, 95%CI1⁄4 1.12–1.34, P1⁄4 7 10 ) but not males (OR 1⁄4 1.02, 95% CI 1⁄4 0.97–1.08, P 1⁄4 0.35; Phet 1⁄4 6 10 ). There was little evidence for a sex difference in the association between this variant and cigarettes smoked per day, with male and female rs16969968 variant carriers smoking approximately the same amount more in the 11,991 ever smokers in the pooled analysis of the 14 studies (Phet 1⁄4 0.86). Conclusions: This study has confirmed a sex difference in the association between the 15q25 variant rs16969968 and UADT cancers. Impact: Further research is warranted to elucidate the mechanisms underlying these observations. Cancer Epidemiol Biomarkers Prev; 20(4); 658–64. 2011 AACR. Authors' Affiliations: International Agency for Research on Cancer (IARC), Lyon, France; Gillings School of Global Public Health; School of Medicine; Otolaryngology/Head and Neck Surgery; and Lineberger Comprehensive Cancer Site, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; University of Pittsburgh, Pittsburgh, Pennsylvania; Instituto de Investigaci on Epidemiol ogica, San Jos e, Costa Rica; National Cancer Institute, IRCSS, Aviano, Italy; Brown University, Providence, Rhode Island; Boston University School of Public Health, Boston, Massachusetts; Department of Otorhinolaryngology and Head and Neck Surgery, Maastricht University Medical Site, Maastricht; and Department of Gastroenterology, Radboud University Nijmegen Medical Site, Nijmegen, the Netherlands; Pomeranian Medical University, Department of Genetics and Pathomorphology, International Hereditary Cancer Site, Szczecin, Poland; Penn State College of Medicine, Hershey, Pennsylvania; University of Texas MD Anderson Cancer Site, Houston, Texas; University of California, Los Angeles, School of Public Health, Los Angeles, California; Fred Hutchinson Cancer Research Site, Seattle, Washington; INSERM U946, Paris; CNRS UMR8200, Gustave Roussy Institute, Villejuif, France; University of Athens School of Medicine, Athens, Greece; Institute of Hygiene and Epidemiology,1st Faculty of Medicine, Charles University in Prague, Czech Republic; Unit of Cancer Epidemiology, University of Turin, Turin, Italy; Cancer Registry of Norway, Oslo, Norway; Institut Catal a d’Oncologia (ICO), Barcelona; and Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiologia y Salud Publica CIBERESP), Spain; School of Medicine and Dentistry, University of Aberdeen, Aberdeen, United Kingdom; General Hospital of Pordenone, Pordenone; Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy; MRC-HPA Centre for Environment and Health, Department of Respiratory Epidemiology and Public Health, D, Imperial College School of Medicine (NHLI), London and; University of Manchester, School of Dentistry, Manchester, United Kingdom; University of Glasgow Dental School, Glasgow, Scotland; Croatian National Cancer Registry, Croatian National Institute of Public Cancer Epidemiology, Biomarkers & Prevention Cancer Epidemiol Biomarkers Prev; 20(4) April 2011 658 American Association for Cancer Research Copyright © 2011 on June 4, 2012 cebp.aacrjournals.org Downloaded from Published OnlineFirst February 18, 2011; DOI:10.1158/1055-9965.EPI-10-1008
24 May 2011