D
Derrick W. Crook
Researcher at University of Oxford
Publications - 510
Citations - 38699
Derrick W. Crook is an academic researcher from University of Oxford. The author has contributed to research in topics: Population & Medicine. The author has an hindex of 92, co-authored 474 publications receiving 29885 citations. Previous affiliations of Derrick W. Crook include Oxford Brookes University & The Chinese University of Hong Kong.
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Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera.
D. Zhou,Wanwisa Dejnirattisai,P Supasa,Chang Liu,Alexander J. Mentzer,Helen M. Ginn,Yuguang Zhao,Duyvesteyn Hme.,Aekkachai Tuekprakhon,R Nutalai,Beibei Wang,Guido C. Paesen,Cesar Lopez-Camacho,J Slon-Campos,Bassam Hallis,Naomi Coombes,Kevin R. Bewley,Sue Charlton,Thomas S. Walter,Donal T. Skelly,Sheila F Lumley,Christina Dold,R Levin,Tao Dong,Andrew J. Pollard,Julian C. Knight,Derrick W. Crook,Teresa Lambe,Elizabeth A. Clutterbuck,S Bibi,Amy Flaxman,M Bittaye,Sandra Belij-Rammerstorfer,Sarah C. Gilbert,William James,Miles W. Carroll,Paul Klenerman,Eleanor Barnes,Susanna Dunachie,Elizabeth E. Fry,Juthathip Mongkolsapaya,Jingshan Ren,David I. Stuart,Gavin R. Screaton +43 more
TL;DR: In this paper, a structure-function analysis of B.1.351 was performed using a large cohort of convalescent and vaccinee serum samples, and it was shown that the receptor-binding domain mutations provide tighter ACE2 binding and widespread escape from monoclonal antibody neutralization largely driven by E484K, although K417N and N501Y act together against some important antibody classes.
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Whole-genome sequencing to delineate Mycobacterium tuberculosis outbreaks: a retrospective observational study
Timothy M Walker,Camilla L. C. Ip,Ruth H. Harrell,Jason T. Evans,Georgia Kapatai,Martin Dedicoat,David W Eyre,Daniel J. Wilson,Peter M. Hawkey,Peter M. Hawkey,Derrick W. Crook,Julian Parkhill,David Harris,A. Sarah Walker,Rory Bowden,Philip Monk,E. Grace Smith,Tim E. A. Peto +17 more
TL;DR: The genetic diversity of related M tuberculosis strains in the UK Midlands is estimated and the technique could identify super-spreaders and predict the existence of undiagnosed cases, potentially leading to early treatment of infectious patients and their contacts.
Journal ArticleDOI
Genomic islands: tools of bacterial horizontal gene transfer and evolution.
Mario Juhas,Jan Roelof van der Meer,Muriel Gaillard,Rosalind M. Harding,Derek W. Hood,Derrick W. Crook +5 more
TL;DR: Genomic islands play a crucial role in the evolution of a broad spectrum of bacteria as they are involved in the dissemination of variable genes, including antibiotic resistance and virulence genes leading to generation of hospital ‘superbugs’, as well as catabolic genes lead to formation of new metabolic pathways.
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SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses
Wanwisa Dejnirattisai,Jiandong Huo,D. Zhou,Jiří Zahradník,P Supasa,Changxiao Liu,Helen M. E. Duyvesteyn,Helen M. Ginn,Alexander J. Mentzer,Aekkachai Tuekprakhon,Rungtiwa Nutalai,Beibei Wang,Aiste Dijokaite,Suman Khan,Ori Avinoam,M.W. Bahar,Donal T. Skelly,S Adele,Síle A. Johnson,Thomas G Ritter,Chris Jb Mason,Christina Dold,Daniel Pan,Sara Assadi,A. Bellass,Nikki Omo-Dare,David Koeckerling,Amy Flaxman,D Jenkin,Parvinder K. Aley,Merryn Voysey,Sue Ann Costa Clemens,Felipe Gomes Naveca,Valdinete Alves do Nascimento,Fernanda Nascimento,Cristiano Fernandes da Costa,Paola Cristina Resende,Alex Pauvolid-Corrêa,Marilda M. Siqueira,Vicky L. Baillie,Natali Serafin,Gaurav Kwatra,Kelly Da Silva,Shabir A. Madhi,Marta C. Nunes,Tariq Mehmood Malik,Peter J. M. Openshaw,J Kenneth Baillie,Malcolm G Semple,Alain Townsend,Kuan-Ying A. Huang,Tiong Kit Tan,Miles W. Carroll,Paul Klenerman,Eleanor Barnes,Susanna Dunachie,Bede Constantinides,Hermione J. Webster,Derrick W. Crook,Andrew J. Pollard,Teresa Lambe,Neil G. Paterson,Mark Williams,Elizabeth E. Fry,Juthathip Mongkolsapaya,Jingshan Ren,Gideon Schreiber,David Stuart,Gavin R. Screaton +68 more
TL;DR: In this article , a new SARS-CoV-2 viral isolate Omicron-B.1.529 was announced, containing far more mutations in Spike (S) than previously reported variants, leading to a large number of mutations in the ACE2 binding site and rebalances receptor affinity to that of earlier pandemic viruses.
Journal ArticleDOI
Prospective evaluation of criteria for microbiological diagnosis of prosthetic-joint infection at revision arthroplasty. The OSIRIS Collaborative Study Group.
Bridget L. Atkins,Nicholas A. Athanasou,Jonathan J Deeks,Derrick W. Crook,Hamish Simpson,Tim E. A. Peto,Peter McLardy-Smith,Anthony R. Berendt,Anthony R. Berendt +8 more
TL;DR: It is recommended that five or six specimens be sent, that the cutoff for a definite diagnosis of infection be three or more operative specimens that yield an indistinguishable organism, and that because of its low level of sensitivity, Gram staining should be abandoned as a diagnostic tool at elective revision arthroplasty.