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Douglas B. Kell

Researcher at University of Liverpool

Publications -  657
Citations -  55792

Douglas B. Kell is an academic researcher from University of Liverpool. The author has contributed to research in topics: Systems biology & Dielectric. The author has an hindex of 111, co-authored 634 publications receiving 50335 citations. Previous affiliations of Douglas B. Kell include Max Planck Society & University of Wales.

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The protonmotive force in phosphorylating membrane vesicles from Paracoccus denitrificans. Magnitude, sites of generation and comparison with the phosphorylation potential.

TL;DR: The result may indicate either that there is no relationship between the protonmotive force and DeltaG(p), or that for an unidentified reason the equilibration of SCN(-) or methylamine with the membrane potential and the pH gradient is prevented by NO(3) (-) in this system.

The role of modeling in systems biology

TL;DR: The role in part is to explain why this type of mathematical model is both useful and important, and will likely become part of the standard armory of successful biologists.
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A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications

TL;DR: It is argued that the ability of these fibrin amyloid microclots (fibrinaloids) to block up capillaries, and thus to limit the passage of red blood cells and hence O2 exchange, can actually underpin the majority of these symptoms.
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High-throughput metabolic fingerprinting of legume silage fermentations via Fourier transform infrared spectroscopy and chemometrics.

TL;DR: A holistic metabolic fingerprinting approach was used, combining a high-throughput microtiter plate-based fermentation system with Fourier transform infrared (FT-IR) spectroscopy, to obtain a snapshot of the sample metabolome at a given time to study the dynamics of red clover or grass silage fermentations in response to various inoculants incorporating lactic acid bacteria.
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Genome-wide assessment of the carriers involved in the cellular uptake of drugs: a model system in yeast

TL;DR: A chemical genomics platform built upon the yeast gene deletion collection is constructed, using competition experiments in batch fermenters and robotic automation of cytotoxicity screens, including protection by 'natural' substrates to substantiate the notion that the cellular uptake of pharmaceutical drugs normally occurs via carrier-mediated transport.