D
Douglas B. Kell
Researcher at University of Liverpool
Publications - 657
Citations - 55792
Douglas B. Kell is an academic researcher from University of Liverpool. The author has contributed to research in topics: Systems biology & Dielectric. The author has an hindex of 111, co-authored 634 publications receiving 50335 citations. Previous affiliations of Douglas B. Kell include Max Planck Society & University of Wales.
Papers
More filters
Journal ArticleDOI
Implications of the dominant role of transporters in drug uptake by cells.
TL;DR: Drug uptake is understood to be mainly transporter-mediated, which suggests that uptake transporters may be a major determinant of idiosyncratic drug response and a site at which drug-drug interactions occur.
Journal ArticleDOI
SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: implications for microclot formation in COVID-19.
Lize M Grobbelaar,Chantelle Venter,Maré Vlok,Malebogo Ngoepe,Malebogo Ngoepe,Gert Jacobus Laubscher,Petrus Johannes Lourens,Janami Steenkamp,Douglas B. Kell,Douglas B. Kell,Douglas B. Kell,Etheresia Pretorius +11 more
TL;DR: In this paper, the effect of isolated SARS-CoV-2 spike protein S1 subunit as potential inflammagen sui generis was investigated using scanning electron and fluorescence microscopy as well as mass spectrometry, and the potential of this inflammagen to interact with platelets and fibrin(ogen) directly to cause blood hypercoagulation.
Journal ArticleDOI
Diffuse reflectance absorbance spectroscopy taking in chemometrics (DRASTIC). A hyperspectral FT-IR-based approach to rapid screening for metabolite overproduction
Michael K. Winson,Royston Goodacre,Éadaoin M. Timmins,Alun Jones,Bjørn K. Alsberg,Andrew M. Woodward,Jem J. Rowland,Douglas B. Kell +7 more
TL;DR: In this paper, a combination of principal components analysis (PCA), artificial neural networks (ANNs) and partial least squares regression (PLS) was used to detect ampicillin overproduction in the mid-infrared.
Journal ArticleDOI
Genotype-phenotype mapping: genes as computer programs.
TL;DR: The encoding of cellular and higher-order activities by genes is seen as directly analogous to computer programs and is of utility in biological genetics and in problems of genotype-phenotype mapping.
Journal ArticleDOI
Mosaic protonic coupling hypothesis for free energy transduction
Hans V. Westerhoff,B. Andrea Melandri,Giovanni Venturoli,Giovanni Venturoli,Giovanni Felice Azzone,Douglas B. Kell +5 more
TL;DR: This poster presents a probabilistic study of the phytochemical properties of mitochondria, the building block of DNA that acts as a “spatially aggregating force” to form DNA.