Douglas B. Kell

TL;DR: This work exploits the recent availability of a community reconstruction of the human metabolic network to study how close in structural terms are marketed drugs to the nearest known metabolite(s) that Recon2 contains, and suggests a ‘rule of 0.5’ mnemonic for assessing the metabolite-like properties that characterise successful, marketed drugs.

TL;DR: The axial ratio of the erythrocytes of poorly controlled type 2 diabetics was significantly increased, and that their fibrin morphologies were again highly aberrant, but these could be reversed, to some degree, by the addition of the iron chelators deferoxamine (DFO) or deferasirox (DFX).

TL;DR: It is argued that bacterial cell wall components, such as the endotoxin lipopolysaccharide (LPS) of Gram-negative strains, might be the cause of the continuing and low-grade inflammation, characteristic of AD.

TL;DR: The identification of chaotic growth rates in cell cultures suggests that there may be novel methods for controlling the growth of such cultures.

TL;DR: The analysis demonstrates the commonalities underpinning a variety of pathologies as seen in both hypercoagulability and hypofibrinolysis, and offers opportunities for both diagnostics and therapies.