D
Douglas B. Kell
Researcher at University of Liverpool
Publications - 657
Citations - 55792
Douglas B. Kell is an academic researcher from University of Liverpool. The author has contributed to research in topics: Systems biology & Dielectric. The author has an hindex of 111, co-authored 634 publications receiving 50335 citations. Previous affiliations of Douglas B. Kell include Max Planck Society & University of Wales.
Papers
More filters
Posted ContentDOI
Untargeted metabolomics of COVID-19 patient serum reveals potential prognostic markers of both severity and outcome.
Ivayla Roberts,Marina Wright Muelas,Joseph M Taylor,Andrew S. Davison,Yun Xu,Justine M. Grixti,Nigel Gotts,Anatolii Sorokin,Royston Goodacre,Douglas B. Kell,Douglas B. Kell +10 more
TL;DR: A well-powered, untargeted metabolomics assessment of 120 COVID-19 patient samples acquired at hospital admission is provided to predict patient's infection severity and potential outcome and prognostic tests based on the markers discussed in this paper could allow improvement in the planning of patient treatment.
Journal ArticleDOI
On proton-coupled information transfer along the surface of biological membranes and the mode of action of certain colicins
TL;DR: This article aims to develop the idea that energytransducing membrane systems normally contain a number of proteinaceous components whose role is to act co-operatively as conformationally switchable proton conductors, permitting fast, controlled lateral proton transfer along the surface of such energy- transducing membranes.
Journal ArticleDOI
The RESOLUTE consortium: unlocking SLC transporters for drug discovery.
Giulio Superti-Furga,Daniel Lackner,Tabea Wiedmer,Alvaro Ingles-Prieto,Barbara Barbosa,Enrico Girardi,Ulrich Goldmann,Bettina Gürtl,Kristaps Klavins,Christoph Klimek,Sabrina Lindinger,Eva Liñeiro-Retes,André C. Müller,Svenja Onstein,Gregor Redinger,Daniela Reil,Vitaly Sedlyarov,Gernot Wolf,Matthew Crawford,Robert Everley,David Hepworth,Shenping Liu,Stephen Noell,Mary Piotrowski,Robert V. Stanton,Hui Zhang,Salvatore Corallino,Andrea Faedo,Maria Insidioso,Giovanna Maresca,Loredana Redaelli,Francesca Sassone,Lia Scarabottolo,Michela Stucchi,Paola Tarroni,Sara Tremolada,Helena Batoulis,Andreas Becker,Eckhard Bender,Yung-Ning Chang,Alexander Ehrmann,Anke Müller-Fahrnow,Vera Pütter,Diana Zindel,Bradford Hamilton,Martin Lenter,Diana Santacruz,Coralie Viollet,Charles E. Whitehurst,Kai Johnsson,Philipp Leippe,Birgit Baumgarten,Lena Chang,Yvonne Ibig,Martin Pfeifer,Jürgen Reinhardt,Julian Schönbett,Paul Selzer,Klaus Seuwen,Charles Bettembourg,Bruno Biton,Jörg Czech,Hélène de Foucauld,Michel Didier,Thomas Licher,Vincent Mikol,Antje Pommereau,Frédéric Puech,Veeranagouda Yaligara,Aled M. Edwards,Brandon J. Bongers,Laura H. Heitman,Ad P. IJzerman,Huub J. Sijben,Gerard J. P. van Westen,Justine Grixti,Douglas B. Kell,Farah Mughal,Neil Swainston,Marina Wright-Muelas,Tina Bohstedt,N.A. Burgess-Brown,Liz Carpenter,Katharina L. Dürr,Jesper Hansen,Andreea Scacioc,Giulia Banci,Claire Colas,Daniela Digles,Gerhard F. Ecker,Barbara Füzi,Viktoria Gamsjäger,Melanie Grandits,Riccardo Martini,Florentina Troger,Patrick Altermatt,Cédric Doucerain,Franz Dürrenberger,Vania Manolova,Anna-Lena Steck,Hanna Sundström,Maria Wilhelm,Claire M. Steppan +102 more
TL;DR: The Innovative Medicines Initiative Consortium RESOLUTE has started to develop tools and produce data sets to de-orphanize transporters in the solute carrier protein (SLC) superfamily, thereby lowering the barrier for the scientific community to explore SLCs as an attractive drug target class.
Journal ArticleDOI
Mining metabolites: extracting the yeast metabolome from the literature
Chikashi Nobata,Paul D. Dobson,S A Iqbal,Pedro Mendes,Pedro Mendes,Jun'ichi Tsujii,Jun'ichi Tsujii,Douglas B. Kell,Sophia Ananiadou +8 more
TL;DR: A novel tool to automatically identify metabolite names in the literature, and associate structures where possible, to define the reported yeast metabolome and, where structure identification fails, has been able to suggest extensions to ChemSpider.
Journal ArticleDOI
Correlative Light-Electron Microscopy detects lipopolysaccharide and its association with fibrin fibres in Parkinson’s Disease, Alzheimer’s Disease and Type 2 Diabetes Mellitus
Greta M. de Waal,Lize Engelbrecht,Tanja Davis,Willem J.S. de Villiers,Douglas B. Kell,Douglas B. Kell,Etheresia Pretorius +6 more
TL;DR: Data are consistent with the Iron Dysregulation and Dormant Microbes (IDDM) hypothesis in which bacterial inflammagens such as LPS are responsible for anomalous blood clotting as part of the aetiology of these chronic inflammatory diseases.