Douglas B. Kell

TL;DR: The VAE vector distances provide a rapid and novel metric for molecular similarity that is both easily and rapidly calculated.

TL;DR: In this article, the authors analyse quantitatively a mathematical model consisting of one generic equilibrative transporter and one generic concentrative uptake transporter (representing any number of each), together with one generic efflux transporter.

TL;DR: In a recent workshop sponsored by the UK Biotechnolog9and Biological Sciences Research Council, a variety of speakers demonstrated how our knowledge of natural evolutionary processes, and our ability to manipulate nucleotide sequences both in vitro and in vivo, lead, in some instances, to the development of greatly improved cells and enzymes capable of displaying highly desirable and novel metabolic activities, as well as to novel and potent analytical methods as discussed by the authors.

TL;DR: This method was used for a detailed study of the enyzmology of the overall reaction catalysed by pyruvate synthase in Clostridium sporogenes and could be utilised to harness such reductive carboxylations for commercial biotransformations of xenobiotics.