Douglas B. Kell

TL;DR: A generic approach to combine numerical optimization methods with biochemical kinetic simulations is described, suitable for use in the rational design of improved metabolic pathways with industrial significance and for solving the inverse problem of metabolic pathways.

TL;DR: The following topics are discussed: a summary of dielectric theory; amino acids, peptides, proteins and DNA; bound water in biological systems; biological electrolytes; membranes and cells; tissues.

TL;DR: This work describes how it has produced a consensus metabolic network reconstruction for S. cerevisiae, and places special emphasis on referencing molecules to persistent databases or using database-independent forms, such as SMILES or InChI strings, as this permits their chemical structure to be represented unambiguously and in a manner that permits automated reasoning.

TL;DR: It is argued that failure to differentiate clearly between use of the terms ‘viability’ and ‘culturability” in an operational versus a conceptual sense is fuelling the current debate, and an alternative operational terminology is suggested that replaces ‘VBNC’ with expressions that are internally consistent.

TL;DR: A physically implemented robotic system that applies techniques from artificial intelligence to carry out cycles of scientific experimentation and shows that an intelligent experiment selection strategy is competitive with human performance and significantly outperforms, with a cost decrease of 3-fold and 100-fold, both cheapest and random-experiment selection.