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Douglas B. Kell
Researcher at University of Liverpool
Publications - 657
Citations - 55792
Douglas B. Kell is an academic researcher from University of Liverpool. The author has contributed to research in topics: Systems biology & Dielectric. The author has an hindex of 111, co-authored 634 publications receiving 50335 citations. Previous affiliations of Douglas B. Kell include Max Planck Society & University of Wales.
Papers
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Journal ArticleDOI
Erratum to: A ‘rule of 0.5’ for the metabolite-likeness of approved pharmaceutical drugs
Proceedings ArticleDOI
Rapid prediction of optimum population size in genetic programming using a novel genotype -: fitness correlation
David C. Wedge,Douglas B. Kell +1 more
TL;DR: It is demonstrated that genotype-fitness correlations may be used to estimate optimum population sizes for the six problems and is an important step towards the development of an adaptive algorithm that can respond to the perceived landscape in 'real-time', i.e. during the evolutionary search process itself.
Journal ArticleDOI
Hitchhiking into the cell.
TL;DR: A new survey with CRISPR–Cas9 shows the widespread importance of protein transporters called solute carriers (SLCs) in the transport of bioactive drugs.
Journal ArticleDOI
The Transporter-Mediated Cellular Uptake and Efflux of Pharmaceutical Drugs and Biotechnology Products: How and Why Phospholipid Bilayer Transport Is Negligible in Real Biomembranes
TL;DR: In this paper, it was shown that the likelihood of pharmaceutical drugs being able to diffuse through whatever unhindered phospholipid bilayer may exist in intact biological membranes in vivo is vanishingly low.
Posted ContentDOI
A dormant microbial component in the development of pre-eclampsia
Douglas B. Kell,Louise C. Kenny +1 more
TL;DR: There is considerable evidence to the effect that each of these phenomena are caused by the resuscitation of dormant bacteria that shed known and potent inflammagens such as LPS, often as a consequence of iron availability, and PE is thus seen as a milder form of sepsis.