E
Erik Ingelsson
Researcher at Stanford University
Publications - 546
Citations - 99427
Erik Ingelsson is an academic researcher from Stanford University. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 124, co-authored 538 publications receiving 85407 citations. Previous affiliations of Erik Ingelsson include Karolinska Institutet & Cardiovascular Institute of the South.
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Journal ArticleDOI
Genetic regulation of gene expression and splicing during a 10-year period of human aging
Brunilda Balliu,Matthew G. Durrant,Olivia M. De Goede,Nathan S. Abell,Xin Li,Boxiang Liu,Michael J. Gloudemans,Naomi L. Cook,Kevin S. Smith,David A. Knowles,Mauro Pala,Francesco Cucca,David Schlessinger,Siddhartha Jaiswal,Chiara Sabatti,Lars Lind,Erik Ingelsson,Erik Ingelsson,Stephen B. Montgomery +18 more
TL;DR: It is demonstrated that, although the transcriptome and its genetic regulation is mostly stable late in life, a small subset of genes is dynamic and is characterized by a reduction in genetic regulation, most likely due to increasing environmental variance with age.
Journal ArticleDOI
Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology
Yosuke Tanigawa,Jiehan Li,Jiehan Li,Johanne Marie Justesen,Johanne Marie Justesen,Heiko Horn,Heiko Horn,Matthew Aguirre,Christopher DeBoever,Christopher C. Chang,Balasubramanian Narasimhan,Kasper Lage,Kasper Lage,Kasper Lage,Trevor Hastie,Chong Yon Park,Gill Bejerano,Erik Ingelsson,Erik Ingelsson,Manuel A. Rivas +19 more
TL;DR: The authors propose decomposition of genetic associations (DeGAs), which uses singular value decomposition, to characterize the underlying latent structure of genetic association of 2,138 phenotypes.
Posted ContentDOI
Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
Anubha Mahajan,Daniel Taliun,Matthias Thurner,Neil R. Robertson,Jason M. Torres,N. William Rayner,Valgerdur Steinthorsdottir,Robert A. Scott,Niels Grarup,James P. Cook,Ellen M. Schmidt,Matthias Wuttke,Chloé Sarnowski,Reedik Mägi,Jana Nano,Christian Gieger,Stella Trompet,Cécile Lecoeur,Michael Preuss,Bram P. Prins,Xiuqing Guo,Lawrence F. Bielak,Amanda J. Bennett,Jette Bork-Jensen,Chad M. Brummett,Mickaël Canouil,Kai-Uwe Eckardt,Krista Fischer,Sharon L.R. Kardia,Florian Kronenberg,Kristi Läll,Ching-Ti Liu,Adam E. Locke,Jian'an Luan,Ioanna Ntalla,Vibe Nylander,Sebastian Schönherr,Claudia Schurmann,Loic Yengo,Erwin P. Bottinger,Ivan Brandslund,Cramer Christensen,George Dedoussis,Jose C. Florez,Ian Ford,Oscar H. Franco,Timothy M. Frayling,Vilmantas Giedraitis,Sophie Hackinger,Andrew T. Hattersley,Christian Herder,M. Arfan Ikram,Martin Ingelsson,Marit E. Jørgensen,Torben Jørgensen,Jennifer Kriebel,Johanna Kuusisto,Symen Ligthart,Cecilia M. Lindgren,Allan Linneberg,Valeriya Lyssenko,Vasiliki Mamakou,Thomas Meitinger,Karen L. Mohlke,Andrew D. Morris,Girish N. Nadkarni,James S. Pankow,Annette Peters,Naveed Sattar,Alena Stančáková,Konstantin Strauch,Kent D. Taylor,Barbara Thorand,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Jaakko Tuomilehto,Daniel R. Witte,Josée Dupuis,Patricia A. Peyser,Eleftheria Zeggini,Ruth J. F. Loos,Philippe Froguel,Erik Ingelsson,Lars Lind,Leif Groop,Markku Laakso,Francis S. Collins,J. Wouter Jukema,Colin N. A. Palmer,Harald Grallert,Andres Metspalu,Abbas Dehghan,Anna Köttgen,Gonçalo R. Abecasis,James B. Meigs,Jerome I. Rotter,Jonathan Marchini,Oluf Pedersen,Torben Hansen,Claudia Langenberg,Nicholas J. Wareham,Kari Stefansson,Anna L. Gloyn,Andrew P. Morris,Michael Boehnke,Mark I. McCarthy +105 more
TL;DR: Increase in sample size and variant diversity deliver enhanced discovery and single-variant resolution of causal T2D-risk alleles, and the consequent impact on mechanistic insights and clinical translation is highlighted.
Journal ArticleDOI
A MUTYH germline mutation is associated with small intestinal neuroendocrine tumors.
Jan P. Dumanski,Chiara Rasi,Peyman Björklund,Hanna Davies,Abir Salwa Ali,Malin Grönberg,Staffan Welin,Halfdan Sorbye,Henning Grønbæk,Janet L. Cunningham,Lars Forsberg,Lars Lind,Erik Ingelsson,Peter Stålberg,Per Hellman,Eva Tiensuu Janson +15 more
TL;DR: The results suggest that p.(Gly396Asp) in MUTYH, and potentially other mutations in additional members of the same DNA excision-repair pathway (such as the OGG1 gene) might be involved in driving the tumorigenesis leading to familial and sporadic SI-NETs.
Journal ArticleDOI
Genetic predictors of testosterone and their associations with cardiovascular disease and risk factors: A Mendelian randomization investigation.
C. Mary Schooling,C. Mary Schooling,Shan Luo,Shiu Lun Au Yeung,Deborah J. Thompson,Savita Karthikeyan,Thomas Bolton,Amy M. Mason,Erik Ingelsson,Erik Ingelsson,Stephen Burgess +10 more
TL;DR: Sex hormone-related mechanisms appear to be relevant to cardiovascular risk factors and for stroke (particularly for men), however, the extent that these findings are specifically informative about endogenous testosterone or testosterone supplementation is unclear.