E
Erik Ingelsson
Researcher at Stanford University
Publications - 546
Citations - 99427
Erik Ingelsson is an academic researcher from Stanford University. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 124, co-authored 538 publications receiving 85407 citations. Previous affiliations of Erik Ingelsson include Karolinska Institutet & Cardiovascular Institute of the South.
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Journal ArticleDOI
Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9
Amand F. Schmidt,Amand F. Schmidt,Michael V. Holmes,David Preiss,Daniel I. Swerdlow,Daniel I. Swerdlow,Spiros Denaxas,Spiros Denaxas,Ghazaleh Fatemifar,Rupert Faraway,Chris Finan,Dennis Valentine,Zammy Fairhurst-Hunter,Fernando Pires Hartwig,Bernardo L. Horta,Elina Hyppönen,Elina Hyppönen,Christine Power,Max Moldovan,Erik P A Van Iperen,Kees Hovingh,Ilja Demuth,Kristina Norman,Kristina Norman,Elisabeth Steinhagen-Thiessen,Juri Demuth,Lars Bertram,Lars Bertram,Christina M. Lill,Christina M. Lill,Stefan Coassin,Johann Willeit,Stefan Kiechl,Karin Willeit,Karin Willeit,Dan Mason,John Wright,Richard W Morris,Goya Wanamethee,Peter H. Whincup,Yoav Ben-Shlomo,Stela McLachlan,Jackie F. Price,Mika Kivimäki,Catherine Welch,Adelaida Sanchez-Galvez,Pedro Marques-Vidal,Andrew N. Nicolaides,Andrew N. Nicolaides,Andrie G. Panayiotou,N. Charlotte Onland-Moret,Yvonne T. van der Schouw,Giuseppe Matullo,Giovanni Fiorito,Simonetta Guarrera,Carlotta Sacerdote,Nicholas J. Wareham,Claudia Langenberg,Robert A. Scott,Jian'an Luan,Martin Bobak,Sofia Malyutina,Andrzej Pajak,Ruzena Kubinova,Abdonas Tamosiunas,Hynek Pikhart,Niels Grarup,Oluf Pedersen,Torben Hansen,Allan Linneberg,Tine Jess,Jackie A. Cooper,Steve E. Humphries,Murray H. Brilliant,Terrie Kitchner,Hakon Hakonarson,David Carrell,Catherine A. McCarty,Kirchner H. Lester,Eric B. Larson,David R. Crosslin,Mariza de Andrade,Dan M. Roden,Joshua C. Denny,Cara L. Carty,Stephen Hancock,John Attia,Elizabeth G. Holliday,Rodney J. Scott,Peter W. Schofield,Martin O'Donnell,Salim Yusuf,Michael Chong,Guillaume Paré,Pim van der Harst,Pim van der Harst,M. Abdullah Said,Ruben N. Eppinga,Niek Verweij,Harold Snieder,Tim Christen,Dennis O. Mook-Kanamori,Stefan Gustafsson,Lars Lind,Lars Lind,Erik Ingelsson,Erik Ingelsson,Raha Pazoki,Raha Pazoki,Oscar H. Franco,Albert Hofman,André G. Uitterlinden,Abbas Dehghan,Alexander Teumer,Sebastian E. Baumeister,Sebastian E. Baumeister,Marcus Dörr,Markus M. Lerch,Uwe Völker,Henry Völzke,Joey Ward,Jill P. Pell,Tom W. Meade,Ingrid E. Christophersen,Anke H. Maitland-van der Zee,Anke H. Maitland-van der Zee,Ekaterina V. Baranova,Robin Young,Ian Ford,Archie Campbell,Sandosh Padmanabhan,Michiel L. Bots,Diederick E. Grobbee,Philippe Froguel,Philippe Froguel,Dorothée Thuillier,Ronan Roussel,Amélie Bonnefond,Bertrand Cariou,Melissa C. Smart,Yanchun Bao,Meena Kumari,Anubha Mahajan,Jemma C. Hopewell,Sudha Seshadri,Caroline Dale,Rui Bebiano Da Providencia E Costa,Paul M. Ridker,Daniel I. Chasman,Alexander P. Reiner,Marylyn D. Ritchie,Leslie A. Lange,Alex J. Cornish,Sara E. Dobbins,Kari Hemminki,Ben Kinnersley,Marc Sanson,Karim Labreche,Matthias Simon,Melissa L. Bondy,Philip J. Law,Helen E. Speedy,James M. Allan,Ni Li,Molly Went,Niels Weinhold,Gareth J. Morgan,Pieter Sonneveld,Björn Nilsson,Hartmut Goldschmidt,Amit Sud,Andreas Engert,Markus Hansson,Harry Hemingway,Folkert W. Asselbergs,Folkert W. Asselbergs,Riyaz S. Patel,Riyaz S. Patel,Brendan J. Keating,Naveed Sattar,Richard S. Houlston,Juan P. Casas,Aroon D. Hingorani +182 more
TL;DR: Genetic variation at thePCSK9 locus recapitulates the effects of therapeutic inhibition of PCSK9 on major blood lipid fractions and MI, while indicating an increased risk of type 2 diabetes mellitus and no other possible safety concerns were shown.
Journal ArticleDOI
Effects of cigarette smoking on cardiovascular-related protein profiles in two community-based cohort studies
Biying Huang,Biying Huang,Per Svensson,Johan Ärnlöv,Johan Ärnlöv,Johan Sundström,Lars Lind,Erik Ingelsson,Erik Ingelsson +8 more
TL;DR: The findings of the present study suggest that cigarette smoking may interfere with several essential parts of the atherosclerosis process, as evidenced by associations with protein markers representing endothelial dysfunction, inflammation, neointimal formation, foam cell formation and plaque instability.
Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution
Anne E. Justice,Tugce Karaderi,Heather M. Highland,Kristin L. Young,Mariaelisa Graff,Yingchang Lu,Valérie Turcot,Paul L. Auer,Rebecca S. Fine,Xiuqing Guo,Claudia Schurmann,Adelheid Lempradl,Eirini Marouli,Anubha Mahajan,Thomas W. Winkler,Adam E. Locke,Carolina Medina-Gomez,Tõnu Esko,Sailaja Vedantam,Ayush Giri,Ken Sin Lo,Tamuno Alfred,Poorva Mudgal,Maggie C.Y. Ng,Nancy L. Heard-Costa,Mary F. Feitosa,Alisa K. Manning,Sara M. Willems,Suthesh Sivapalaratnam,Gonçalo R. Abecasis,Dewan S. Alam,Matthew A. Allison,Philippe Amouyel,Zorayr Arzumanyanm,Beverley Balkau,Lisa Bastarache,Sven Bergmann,Lawrence F. Bielak,Matthias Blueher,Michael Boehnke,Heiner Boeing,Eric Boerwinkle,Carsten A. Boeger,Jette Bork-Jensen,Erwin P. Bottinger,Donald W. Bowden,Ivan Brandslund,Linda Broer,Amber A. Burt,Adam S. Butterworth,Markj Caulfield,Giancarlo Cesana,John C. Chambers,Chasman, Daniel, I,Yii-Der Ida Chen,Rajiv Chowdhury,Cramer Christensen,Audreyy Chu,Francis S. Collins,James P. Cook,Amanda J. Cox,David S. Crosslin,John Danesh,Paul I. W. de Bakker,Simon de Denus,Renée de Mutsert,George Dedoussis,Ellen W. Demerath,Joe Dennis,Josh C. Denny,Emanuele Di Angelantonio,Marcus Doerr,Fotios Drenos,Marie-Pierre Dubé,Alison M. Dunning,Douglas F. Easton,Paul Elliott,Evangelos Evangelou,Aliki-Eleni Farmaki,Shuang Feng,Ele Ferrannini,Jean Ferrières,Jose C. Florez,Myriam Fornage,Caroline S. Fox,Paul W. Franks,Nele Friedrich,Wei Gan,Ilaria Gandin,Paolo Gasparini,Vilmantas Giedraitis,Giorgia Girotto,Mathias Gorski,Harald Grallert,Niels Grarup,Megan L. Groves,Stefan Gustafsson,Jeffrey Haessler,Torben Hansen,Andrew T. Hattersley,Caroline Hayward,Iris M. Heid,Oddgeir L. Holmen,G. Kees Hovingh,Joanna M. M. Howson,Yao Hu,Yi-Jen Hung,Kristian Hveem,M. Arfan Ikram,Erik Ingelsson,Anne U. Jackson,Gail P. Jarvik,Yucheng Jia,Torben Jørgensen,Pekka Jousilahti,Johanne Marie Justesen,Bratati Kahali,Maria Karaleftheri,Sharon L.R. Kardia,Fredrik Karpe,Frank Kee,Hidetoshi Kitajima,Pirjo Komulainen,Jaspal S. Kooner,Peter Kovacs,Bernhard K. Kraemer,Kari Kuulasmaa,Johanna Kuusisto,Markku Laakso,Timo A. Lakka,David Lamparter,Leslie A. La Nge,Claudia Langenberg,Eric B. Larson,Nanette R. Lee,Wen-Jane Lee,Terho Lehtimaeki,Cora E. Lewis,Huaixing Li,Jin Li,RuifangLi-Gao,Li-An Lin,Xu Lin,Lars Lind,Jaana Lindstroem,Allan Linneberg,Ching-Ti Liu,Dajiang J. Liu,Jian'an Luan,Leo-Pekka Lyytikäinen,Stuart MacGregor,Reedik Mägi,Satu Männistö,Gaëlle Marenne,Jonathan Marten,Nicholas G. D. Mascal,McCarthy, Mark, I,Karina Meidtner,Evelin Mihailov,Leena Moilanen,Marie Moitry,Dennis O. Mook-Kanamori,Anna Morgan,Andrew P. Morris,Martina Mueller-Nurasyid,Patricia B. Munroe,Narisu Narisu,Christopher P. Nelson,Matt J. Neville,Ioanna Ntalla,Katharine R. Owen,Oluf Pedersen,Gina M. Peloso,Craig E. Pennell,Markus Perola,Allan James,John R. B. Perry,Tune H. Pers,Ailith Ewing,Ozren Polasek,Asif Rasheed,Chelsea K. Raulerson,Rainer Rauramaa,Dermot F. Reilly,Alex P. Reiner,Paul M. Ridker,Manuel A. Rivas,Neil R. Robertson,Antonietta Robino,Igor Rudan,Katherine S. Ruth,Danish Saleheen,Veikko Salomaa,Nilesh J. Samani,Pamela J. Schreiner,Matthias B. Schulze,Robert A. Scott,Marcelo P. Segura-Lepe,Xueling Sim,Andrew J. Slater,Kerrin S. Small,Blair H. Smith,Jennifer A. Smith,Lorraine Southam,Tim D. Spector,Elizabeth K. Speliotes,Kari Stefansson,Valgerdur Steinthorsdottir,Kathleen Stirrups,Konstantin Strauch,Heather M. Stringham,Michael Stumvoll,Liang Sun,Praveen Surendran,Karin M. A. Swart,Jean-Claude Tardif,Kent D. Taylor,Alexander Teumer,Deborah J. Thompson,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Betina H. Thuesen,Anke Toenjes,Mina Torres,Emmanouil Tsafantakis,Jaakko Tuomilehto,André G. Uitterlinden,Matti Uusitupa,Cornelia M. van Duijn,Mauno Vanhala,Rohit Varma,Sita H. Vermeulen,Henrik Vestergaard,Veronique Vitart,Thomas F. Vogt,Dragana Vuckovic,Lynne E. Wagenknecht,Mark Walker,Lars Wallentin,Feijie Wang,Carol A. Wang,Shuai Wang,N. Icholas J. Wareham,Helen R. Warren,Dawn M. Waterworth,Jennifer Wessel,Harvey D. White,Cristen J. Willer,James G. Wilson,Andrew R. Wood,Ying Wu,Hanieh Yaghootkar,Jie Yao,Laura M. Verges-Armstrong,Robin Young,Eleftheria Zeggini,Xiaowei Zhan,Weihua Zhang,Jing Hua Zhao,Wei Zhao,He Zheng,Wei Zhou,M. Carola Zillikens,Fernando Rivadeneira,Ingrid B. Borecki,J. Andrew Pospisilik,Panos Deloukas,Timothy M. Frayling,Guillaume Lettre,Karen L. Mohlke,Rotter, Jerome, I,Zoltán Kutalik,Joel N. Hirschhorn,L. Adrienne Cupples,Ruth J. F. Loos,Kari E. North,Cecilia M. Lindgren,Jeffrey R. O'Connell,Olli T. Raitakari,Leslie A. Lange,Andr G. Uitterlinden,Megan L. Grove,Nicholas G. D. Masca,Nicholas J. Wareham,Tnu Esko,Paul I.W. de Bakker,Mark J. Caulfield,Martina Mller-Nurasyid +287 more
TL;DR: A transancestral exome-wide association study for body-fat distribution identifies protein-coding variants that are significantly associated with waist-to-hip ratio adjusted for body mass index.
Journal ArticleDOI
Genome-Wide Association Studies of Estimated Fatty Acid Desaturase Activity in Serum and Adipose Tissue in Elderly Individuals: Associations with Insulin Sensitivity
Matti Marklund,Andrew P. Morris,Anubha Mahajan,Erik Ingelsson,Cecilia M. Lindgren,Cecilia M. Lindgren,Lars Lind,Ulf Risérus +7 more
TL;DR: The FADS cluster was the main genetic determinant of estimated FADS activity, however, fatty acid (FA) ratios in adipose tissue and cholesterol esters represent FADS activities in separate tissues and are thus influenced by different genetic factors with potential varying effects on IS.
Inference of the genetic architecture underlying BMI and height with the use of 20,240 sibling pairs
Gibran Hemani,Jian Yang,Anna A. E. Vinkhuyzen,Joseph E. Powell,Gonneke Willemsen,Jouke-Jan Hottenga,Abdel Abdellaoui,Massimo Mangino,Ana M. Valdes,S. E. Medland,P. A. F. Madden,A. C. Heath,Anjali K. Henders,Dale R. Nyholt,E.J.C. de Geus,Patrik K. E. Magnusson,Erik Ingelsson,Grant W. Montgomery,Tim D. Spector,Dorret I. Boomsma,N L Pedersen,Nicholas G. Martin,Peter M. Visscher +22 more
TL;DR: In this paper, the authors show that the distribution of the observed test statistics is consistent with both rare and common variants underlying a polygenic architecture and that previous reports of linkage signals in complex traits are probably a consequence of polygenicity rather than the segregation of variants with large effects.