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Journal ArticleDOI

Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

Christopher J L Murray, +174 more
- 01 Jan 2022 - 
- Vol. 399, pp 629-655
TLDR
This study provides the first comprehensive assessment of the global burden of AMR, as well as an evaluation of the availability of data, and estimates aggregated to the global and regional level.
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This article is published in The Lancet.The article was published on 2022-01-01. It has received 2222 citations till now. The article focuses on the topics: Medicine.

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Citations
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Journal ArticleDOI

Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019

Kevin S Ikuta, +562 more
- 01 Nov 2022 - 
Journal ArticleDOI

The past, present, and future of antibiotics

TL;DR: The past, present, and future of antimicrobial therapy is explored, including narrow-spectrum drugs, bacteriophage, monoclonal antibodies, and vaccines, coupled with highly effective diagnostics.
Journal ArticleDOI

Progress in Alternative Strategies to Combat Antimicrobial Resistance: Focus on Antibiotics

TL;DR: In this article , the authors present a review of the strategies that are being applied or proposed as potential alternatives to traditional antibiotics, including combination therapy, techniques that target the enzymes or proteins responsible for antimicrobial resistance, resistant bacteria, drug delivery systems, physicochemical methods and unconventional techniques, including the CRISPR-Cas system.
Journal ArticleDOI

The overlooked pandemic of antimicrobial resistance

Ramanan Laxminarayan
- 01 Jan 2022 - 
TL;DR: The study’s estimate of 4·95 million deaths associated with bacterial AMR globally in 2019 indicates that there are substantial gains to be made from preventing infections in the first place, and partly reflects the insufficient access to antibiotics.
Proceedings ArticleDOI

Biological Sequence Design with GFlowNets

TL;DR: This work proposes an active learning algorithm leveraging epistemic uncertainty estimation and the recently proposed GFlowNets as a generator of diverse candidate solutions, with the objective to obtain a diverse batch of useful and novel batches with high scoring candidates after each round.
References
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Journal ArticleDOI

Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care.

TL;DR: Severe sepsis is a common, expensive, and frequently fatal condition, with as many deaths annually as those from acute myocardial infarction, and is especially common in the elderly and is likely to increase substantially as the U.S. population ages.
Journal ArticleDOI

Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Theo Vos, +2419 more
- 17 Oct 2020 - 
TL;DR: Global health has steadily improved over the past 30 years as measured by age-standardised DALY rates, and there has been a marked shift towards a greater proportion of burden due to YLDs from non-communicable diseases and injuries.
Journal ArticleDOI

The Epidemiology of Sepsis in the United States from 1979 through 2000

TL;DR: The rate of sepsis due to fungal organisms increased by 207 percent, with gram-positive bacteria becoming the predominant pathogens after 1987, and the total in-hospital mortality rate fell, yet the total number of deaths continued to increase.