H
Hong Zhang
Researcher at Chinese Academy of Sciences
Publications - 482
Citations - 15856
Hong Zhang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Synthetic aperture radar & Autophagy. The author has an hindex of 52, co-authored 384 publications receiving 11989 citations. Previous affiliations of Hong Zhang include Indiana University – Purdue University Indianapolis & ShanghaiTech University.
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Journal ArticleDOI
Differential Function of the Two Atg4 Homologues in the Aggrephagy Pathway in Caenorhabditis elegans
TL;DR: The two Atg4 homologues in Caenorhabditis elegans have differential enzymatic activities in processing LGG-1/Atg8 and exhibit functional redundancy in the autophagy pathway, revealing that ATG-4.1 and ATG.2 are functionally redundant yet display differential L GG-1 processing and deconjugating activity in the aggrephagy pathway in C. elegans.
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microRNA‐16‐5p enhances radiosensitivity through modulating Cyclin D1/E1–pRb–E2F1 pathway in prostate cancer cells
Fang Wang,Aihong Mao,Jinzhou Tang,Qianjing Zhang,Junfang Yan,Yupei Wang,Cuixia Di,Lu Gan,Chao Sun,Hong Zhang +9 more
TL;DR: In this article, the expression profile of miRNAs in CaP cells exposed to ionizing radiation (IR) was identified and miR-16-5p was found to be significantly overexpressed in all treatment groups that irradiated with different doses of X-rays and heavy ions.
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Identification of lipid droplet structure-like/resident proteins in Caenorhabditis elegans.
Huimin Na,Peng Zhang,Yong Chen,Xiaotong Zhu,Yi Liu,Yangli Liu,Kang Xie,Ningyi Xu,Fuquan Yang,Yong Yu,Simon Cichello,Ho Yi Mak,Meng C. Wang,Hong Zhang,Pingsheng Liu +14 more
TL;DR: It is identified that MDT-28 and DHS-3 previously identified in C. elegans LD proteome were two LD structure-like/resident proteins that were specifically localized to LDs and provide a basis for future mechanistic studies into the dynamics and functions of LDs in the worm.
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Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPα expression
Kol Jia Yong,Daniela S. Basseres,Robert S. Welner,Wen Cai Zhang,Wen Cai Zhang,Wen Cai Zhang,Henry Yang,Benedict Yan,Meritxell Alberich-Jorda,Junyan Zhang,Junyan Zhang,Lorena Lobo de Figueiredo-Pontes,Chiara Battelli,Chiara Battelli,Christopher J. Hetherington,Christopher J. Hetherington,Min Ye,Min Ye,Hong Zhang,Hong Zhang,Giorgia Maroni,Karen B. O'Brien,Karen B. O'Brien,Maria Cristina Magli,Alain C. Borczuk,Lyuba Varticovski,Olivier Kocher,Olivier Kocher,Pu Zhang,Pu Zhang,Young Choon Moon,Nadiya Sydorenko,Liangxian Cao,Thomas W. Davis,Bhavin Thakkar,Ross A. Soo,Ross A. Soo,Atsushi Iwama,Bing Lim,Bing Lim,Bing Lim,Balazs Halmos,Donna Neuberg,Daniel G. Tenen,Daniel G. Tenen,Elena Levantini +45 more
TL;DR: It is shown that C/EBPα is a tumor suppressor in lung cancer and that BMI1 is required for the oncogenic process downstream of C/ EBPα loss, and pharmacological inhibition of BMI1 exhibits antitumor effects in both murine and human adenocarcinoma lines.
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Role of Epg5 in selective neurodegeneration and Vici syndrome.
TL;DR: It is demonstrated that mice deficient for the metazoan-specific autophagy gene Epg5 develop selective neuronal damage and exhibit key characteristics of amyotrophic lateral sclerosis.