H
Hua Shen
Researcher at Baylor College of Medicine
Publications - 11
Citations - 3275
Hua Shen is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Chromosome 19 & Chromosome 21. The author has an hindex of 5, co-authored 9 publications receiving 3035 citations. Previous affiliations of Hua Shen include Human Genome Sequencing Center.
Papers
More filters
Journal ArticleDOI
Somatic mutations affect key pathways in lung adenocarcinoma
Li Ding,Gad Getz,David A. Wheeler,Elaine R. Mardis,Michael D. McLellan,Kristian Cibulskis,Carrie Sougnez,Heidi Greulich,Heidi Greulich,Donna M. Muzny,Margaret Morgan,Lucinda Fulton,Robert S. Fulton,Qunyuan Zhang,Michael C. Wendl,Michael S. Lawrence,David E. Larson,Ken Chen,David J. Dooling,Aniko Sabo,Alicia Hawes,Hua Shen,Shalini N. Jhangiani,Lora Lewis,Otis Hall,Yiming Zhu,Tittu Mathew,Yanru Ren,Jiqiang Yao,Steven E. Scherer,Kerstin Clerc,Ginger A. Metcalf,Brian Ng,Aleksandar Milosavljevic,Manuel L. Gonzalez-Garay,John R. Osborne,Rick Meyer,Xiaoqi Shi,Yuzhu Tang,Daniel C. Koboldt,Ling Lin,Rachel Abbott,Tracie L. Miner,Craig Pohl,Ginger A. Fewell,Carrie A. Haipek,Heather Schmidt,Brian H. Dunford-Shore,Aldi T. Kraja,Seth D. Crosby,Christopher S. Sawyer,Tammi L. Vickery,Sacha N. Sander,Jody S. Robinson,Wendy Winckler,Wendy Winckler,Jennifer Baldwin,Lucian R. Chirieac,Amit Dutt,Amit Dutt,Timothy Fennell,Megan Hanna,Megan Hanna,Bruce E. Johnson,Robert C. Onofrio,Roman K. Thomas,Giovanni Tonon,Barbara A. Weir,Barbara A. Weir,Xiaojun Zhao,Xiaojun Zhao,Liuda Ziaugra,Michael C. Zody,Thomas J. Giordano,Mark B. Orringer,Jack A. Roth,Margaret R. Spitz,Ignacio I. Wistuba,Bradley A. Ozenberger,Peter J. Good,Andrew C. Chang,David G. Beer,Mark A. Watson,Marc Ladanyi,Stephen R. Broderick,Akihiko Yoshizawa,William D. Travis,William Pao,Michael A. Province,George M. Weinstock,Harold E. Varmus,Stacey Gabriel,Eric S. Lander,Richard A. Gibbs,Matthew Meyerson,Matthew Meyerson,Richard K. Wilson +96 more
TL;DR: Somatic mutations in primary lung adenocarcinoma for several tumour suppressor genes involved in other cancers and for sequence changes in PTPRD as well as the frequently deleted gene LRP1B are found.
Journal ArticleDOI
Large scale variation in Enterococcus faecalis illustrated by the genome analysis of strain OG1RF
Agathe Bourgogne,Danielle A. Garsin,Xiang Qin,Kavindra V. Singh,Jouko Sillanpää,Shailaja Yerrapragada,Yan Ding,Shannon Dugan-Rocha,Christian J. Buhay,Hua Shen,Guan Chen,Gabrielle Williams,Donna M. Muzny,Arash Maadani,Kristina A. Fox,Jason Gioia,Lei Chen,Yue Shang,Cesar A. Arias,Sreedhar R. Nallapareddy,Meng Zhao,Vittal P. Prakash,Shahreen Chowdhury,Huaiyang Jiang,Richard A. Gibbs,Barbara E. Murray,Sarah K. Highlander,George M. Weinstock +27 more
TL;DR: OG1RF's effects in experimental models suggest that mediators of virulence may be diverse between different E. faecalis strains and that virulence is not dependent on the presence of mobile genetic elements.
Journal ArticleDOI
Strict evolutionary conservation followed rapid gene loss on human and rhesus Y chromosomes
Jennifer F. Hughes,Helen Skaletsky,Laura G. Brown,Tatyana Pyntikova,Tina Graves,Robert S. Fulton,Shannon Dugan,Yan Ding,Christian J. Buhay,Colin Kremitzki,Qiaoyan Wang,Hua Shen,Michael Holder,Donna Villasana,Lynne V. Nazareth,Andrew Cree,Laura Courtney,Joelle Veizer,Holland Kotkiewicz,Ting-Jan Cho,Natalia Koutseva,Steve Rozen,Donna M. Muzny,Wesley C. Warren,Richard A. Gibbs,Richard K. Wilson,David C. Page +26 more
TL;DR: An empirical reconstruction of human MSY evolution is presented, in which each stratum transitioned from rapid, exponential loss of ancestral genes to strict conservation through purifying selection.
Journal ArticleDOI
The DNA sequence, annotation and analysis of human chromosome 3
Donna M. Muzny,Steven E. Scherer,Rajinder Kaul,Jing Wang,Jing Wang,Jing Wang,Jun Yu,Jun Yu,Jun Yu,Ralf Sudbrak,Ralf Sudbrak,Christian J. Buhay,Rui Chen,Andrew Cree,Yan Ding,Shannon Dugan-Rocha,Rachel Gill,Preethi H. Gunaratne,R. Alan Harris,Alicia Hawes,Judith Hernandez,Anne Hodgson,Jennifer Hume,Andrew R. Jackson,Ziad Khan,Christie Kovar-Smith,Lora Lewis,Ryan J. Lozado,Michael L. Metzker,Aleksandar Milosavljevic,George Miner,Margaret Morgan,Lynne V. Nazareth,Graham R. Scott,Erica Sodergren,Xing Zhi Song,David Steffen,Sharon Wei,David A. Wheeler,Mathew W. Wright,Kim C. Worley,Ye Yuan,Zhengdong D. Zhang,Charles Q. Adams,M. Ali Ansari-Lari,Mulu Ayele,Mary J. Brown,Guan Chen,Zhijian J. Chen,James B. Clendenning,Kerstin P. Clerc-Blankenburg,Runsheng Chen,Runsheng Chen,Runsheng Chen,Zhu Chen,Zhu Chen,Zhu Chen,Clay Davis,Oliver Delgado,Huyen Dinh,Wei Dong,Wei Dong,Wei Dong,Heather R. Draper,Stephen Ernst,Gang Fu,Gang Fu,Gang Fu,Manuel L. Gonzalez-Garay,Dawn Garcia,Will Gillett,Jun Gu,Jun Gu,Jun Gu,Bailin Hao,Bailin Hao,Bailin Hao,Eric Haugen,Paul Havlak,Xin He,Steffen Hennig,Songnian Hu,Songnian Hu,Songnian Hu,Wei Huang,Wei Huang,Wei Huang,LaRonda Jackson,Leni S. Jacob,Susan H. Kelly,Michael Kube,Ruth Levy,Zhangwan Li,Bin Liu,Bin Liu,Bin Liu,Jing Liu,Wen Liu,Jing Lu,Manjula Maheshwari,Bao Viet Nguyen,Geoffrey Okwuonu,Anthony Palmeiri,Shiran Pasternak,Lesette Perez,Karen A. Phelps,Farah J.H. Plopper,Boqin Qiang,Boqin Qiang,Boqin Qiang,Christopher K. Raymond,Ruben Rodriguez,Channakhone Saenphimmachak,Jireh Santibanez,Hua Shen,Yan Shen,Yan Shen,Yan Shen,Sandhya Subramanian,Paul E. Tabor,Daniel Verduzco,Lenee Waldron,Jian Wang,Jian Wang,Jian Wang,Jun Wang,Jun Wang,Jun Wang,Qiaoyan Wang,Gabrielle A. Williams,Gane Ka-Shu Wong,Gane Ka-Shu Wong,Gane Ka-Shu Wong,Zhijian Yao,Zhijian Yao,Zhijian Yao,Jing Kun Zhang,Xiuqing Zhang,Xiuqing Zhang,Xiuqing Zhang,Guoping Zhao,Guoping Zhao,Guoping Zhao,Jianling Zhou,Yang Zhou,David L. Nelson,Hans Lehrach,Richard Reinhardt,Susan L. Naylor,Huanming Yang,Huanming Yang,Huanming Yang,Maynard V. Olson,George M. Weinstock,Richard A. Gibbs +154 more
TL;DR: Using genomic sequence from chimpanzee and rhesus macaque, the breakpoints defining a large pericentric inversion that occurred some time after the split of Homininae from Ponginae are characterized and an evolutionary history of the inversion is proposed.
Journal ArticleDOI
The finished DNA sequence of human chromosome 12
Steven E. Scherer,Donna M. Muzny,Christian J. Buhay,Rui Chen,Andrew Cree,Yan Ding,Shannon Dugan-Rocha,Rachel Gill,Preethi H. Gunaratne,R. Alan Harris,Alicia Hawes,Judith Hernandez,Anne Hodgson,Jennifer Hume,Andrew R. Jackson,Ziad Khan,Christie Kovar-Smith,Lora Lewis,Ryan J. Lozado,Michael L. Metzker,Aleksandar Milosavljevic,George Miner,Kate Montgomery,Margaret Morgan,Lynne V. Nazareth,Graham R. Scott,Erica Sodergren,Xing Zhi Song,David Steffen,Ruth C. Lovering,David A. Wheeler,Kim C. Worley,Yi Yuan,Zhengdong D. Zhang,Charles Q. Adams,M. Ali Ansari-Lari,Mulu Ayele,Mary J. Brown,Guan Chen,Zhijian J. Chen,Kerstin P. Clerc-Blankenburg,Clay Davis,Oliver Delgado,Huyen Dinh,Heather R. Draper,Manuel L. Gonzalez-Garay,Paul Havlak,LaRonda Jackson,Leni S. Jacob,Susan H. Kelly,Li Li,Zhangwan Li,Jing Liu,Wen Liu,Jing Lu,Manjula Maheshwari,Bao Viet Nguyen,Geoffrey Okwuonu,Shiran Pasternak,Lesette Perez,Farah J.H. Plopper,Jireh Santibanez,Hua Shen,Paul E. Tabor,Daniel Verduzco,Lenee Waldron,Qiaoyan Wang,Gabrielle A. Williams,Jing Kun Zhang,Jianling Zhou,David L. Nelson,Raju Kucherlapati,George M. Weinstock,Richard A. Gibbs +73 more
TL;DR: Alignment of the human chromosome 12 sequence across vertebrates reveals the origin of individual segments in chicken, and a unique history of rearrangement through rodent and primate lineages.