J
Jacques Côté
Researcher at Laval University
Publications - 160
Citations - 21037
Jacques Côté is an academic researcher from Laval University. The author has contributed to research in topics: Chromatin & Histone. The author has an hindex of 66, co-authored 149 publications receiving 19330 citations. Previous affiliations of Jacques Côté include Howard Hughes Medical Institute & Pennsylvania State University.
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Journal ArticleDOI
Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex.
Patrick A. Grant,Laura J. Duggan,Jacques Côté,S M Roberts,James E. Brownell,Reyes Candau,Reiko Ohba,Tom Owen-Hughes,C D Allis,Fred Winston,Shelley L. Berger,Jerry L. Workman +11 more
TL;DR: The function of Gcn5 as a hist one acetyltransferase within the Ada and SAGA adaptor complexes indicates the importance of histone acetylation during steps in transcription activation mediated by interactions with transcription activators and general transcription factors.
Journal ArticleDOI
NURD, a Novel Complex with Both ATP-Dependent Chromatin-Remodeling and Histone Deacetylase Activities
TL;DR: The results suggest that ATP-dependent chromatin remodeling can participate in transcriptional repression by assisting repressors in gaining access to chromatin.
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ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression
Xiaobing Shi,Tao Hong,Kay L. Walter,Mark D. Ewalt,Eriko Michishita,Tiffany Hung,Dylan Carney,Pedro V. Peña,Fei Lan,Mohan R. Kaadige,Nicolas Lacoste,Christelle Cayrou,Foteini Davrazou,Anjanabha Saha,Bradley R. Cairns,Donald E. Ayer,Tatiana G. Kutateladze,Yang Shi,Jacques Côté,Katrin F. Chua,Katrin F. Chua,Or Gozani +21 more
TL;DR: A novel class of methylated H3K4 effector domains—the PHD domains of the ING (for inhibitor of growth) family of tumour suppressor proteins—are identified and established a pivotal role for trimethylation of H 3K4 in gene repression and, potentially, tumour suppressing mechanisms.
Journal ArticleDOI
New nomenclature for chromatin-modifying enzymes.
C. David Allis,Shelley L. Berger,Jacques Côté,Sharon Y.R. Dent,Thomas Jenuwien,Tony Kouzarides,Lorraine Pillus,Danny Reinberg,Yang Shi,Ramin Shiekhattar,Ali Shilatifard,Jerry L. Workman,Yi Zhang +12 more
TL;DR: The aim of this exhibition was to celebrate the 50th anniversary of the United States Declaration of Independence with a celebration of those who served in the armed forces and those who sacrificed in the conflicts of World War II.
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Stimulation of GAL4 Derivative Binding to Nucleosomal DNA by the Yeast SWI/SNF Complex
TL;DR: It is shown that the purified SWI/SNF complex is composed of 10 subunits and includes the SWI1, SWI2/ SNF2, SWi3, SNF5, and SNF6 gene products, and suggests that a primary role of the SWi/SNf complex is to promote activator binding to nucleosomal DNA.