J
Johanna Lepeule
Researcher at University of Grenoble
Publications - 84
Citations - 3941
Johanna Lepeule is an academic researcher from University of Grenoble. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 18, co-authored 52 publications receiving 2887 citations. Previous affiliations of Johanna Lepeule include Karolinska Institutet & Centre Hospitalier Universitaire de Grenoble.
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Journal ArticleDOI
Chronic exposure to fine particles and mortality: an extended follow-up of the Harvard Six Cities study from 1974 to 2009.
Johanna Lepeule,Francine Laden,Francine Laden,Douglas W. Dockery,Douglas W. Dockery,Joel Schwartz,Joel Schwartz +6 more
TL;DR: Further public policy efforts that reduce fine particulate matter air pollution are likely to have continuing public health benefits, and Poisson models produced similar results.
Journal ArticleDOI
DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis
Bonnie R. Joubert,Janine F. Felix,Paul Yousefi,Kelly M. Bakulski,Allan C. Just,Carrie V. Breton,Sarah E. Reese,Christina A. Markunas,Christina A. Markunas,Rebecca C Richmond,Cheng-Jian Xu,Leanne K. Küpers,Sam S. Oh,Cathrine Hoyo,Olena Gruzieva,Cilla Söderhäll,Lucas A. Salas,Nour Baïz,Hongmei Zhang,Johanna Lepeule,Carlos Ruiz,Symen Ligthart,Tianyuan Wang,Jack A. Taylor,Liesbeth Duijts,Gemma C Sharp,Soesma A Jankipersadsing,Roy Miodini Nilsen,Ahmad Vaez,Ahmad Vaez,M. Daniele Fallin,Donglei Hu,Augusto A. Litonjua,Bernard F. Fuemmeler,Karen Huen,Juha Kere,Inger Kull,Monica Cheng Munthe-Kaas,Ulrike Gehring,Mariona Bustamante,Marie José Saurel-Coubizolles,Bilal M. Quraishi,Jie Ren,Jörg Tost,Juan R. González,Marjolein J. Peters,Siri E. Håberg,Zongli Xu,Joyce B. J. van Meurs,Tom R. Gaunt,Marjan Kerkhof,Eva Corpeleijn,Andrew P. Feinberg,Celeste Eng,Andrea A. Baccarelli,Sara E. Benjamin Neelon,Asa Bradman,Simon Kebede Merid,Anna Bergström,Zdenko Herceg,Hector Hernandez-Vargas,Bert Brunekreef,Mariona Pinart,Barbara Heude,Susan Ewart,Jin Yao,Nathanaël Lemonnier,Oscar H. Franco,Michael C. Wu,Albert Hofman,Albert Hofman,Wendy L. McArdle,Pieter van der Vlies,Fahimeh Falahi,Matthew W. Gillman,Lisa F. Barcellos,Ashok Kumar,Ashok Kumar,Ashok Kumar,Magnus Wickman,Magnus Wickman,Stefano Guerra,Marie-Aline Charles,John W. Holloway,Charles Auffray,Henning Tiemeier,George Davey Smith,Dirkje S. Postma,Marie-France Hivert,Brenda Eskenazi,Martine Vrijheid,Hasan Arshad,Josep M. Antó,Abbas Dehghan,Wilfried Karmaus,Isabella Annesi-Maesano,Jordi Sunyer,Akram Ghantous,Göran Pershagen,Nina Holland,Susan K. Murphy,Dawn L. DeMeo,Esteban G. Burchard,Christine Ladd-Acosta,Harold Snieder,Wenche Nystad,Gerard H. Koppelman,Caroline L Relton,Vincent W. V. Jaddoe,Allen J. Wilcox,Erik Melén,Erik Melén,Stephanie J. London +112 more
TL;DR: This large scale meta-analysis of methylation data identified numerous loci involved in response to maternal smoking in pregnancy with persistence into later childhood and provide insights into mechanisms underlying effects of this important exposure.
Journal ArticleDOI
Ambient air pollution and low birthweight: a European cohort study (ESCAPE)
Marie Pedersen,Lise Giorgis-Allemand,Claire Bernard,Inmaculada Aguilera,Anne-Marie Nybo Andersen,Ferran Ballester,Rob Beelen,Leda Chatzi,Marta Cirach,Asta Danileviciute,Audrius Dedele,Manon van Eijsden,Marisa Estarlich,Ana Fernández-Somoano,Mariana F. Fernández,Francesco Forastiere,Ulrike Gehring,Regina Grazuleviciene,Olena Gruzieva,Barbara Heude,Barbara Heude,Gerard Hoek,Kees de Hoogh,Edith H. van den Hooven,Siri E. Håberg,Vincent W. V. Jaddoe,Claudia Klümper,Michal Korek,Ursula Krämer,Aitana Lerchundi,Johanna Lepeule,Johanna Lepeule,Per Nafstad,Wenche Nystad,Evridiki Patelarou,Evridiki Patelarou,Daniela Porta,Dirkje S. Postma,Ole Raaschou-Nielsen,Peter Rudnai,Jordi Sunyer,Euripides G. Stephanou,Mette Sørensen,Elisabeth Thiering,Derek Tuffnell,Mihály J. Varró,Tanja G. M. Vrijkotte,Alet H. Wijga,Michael Wilhelm,John Wright,Mark J. Nieuwenhuijsen,Göran Pershagen,Göran Pershagen,Bert Brunekreef,Bert Brunekreef,Manolis Kogevinas,Rémy Slama +56 more
TL;DR: Exposure to ambient air pollutants and traffic during pregnancy is associated with restricted fetal growth and a substantial proportion of cases of low birthweight at term could be prevented in Europe if urban air pollution was reduced.
Journal ArticleDOI
Maternal Exposure to Particulate Air Pollution and Term Birth Weight: A Multi-Country Evaluation of Effect and Heterogeneity
Payam Dadvand,Jennifer D. Parker,Michelle L. Bell,Matteo Bonzini,Michael Brauer,Lyndsey A. Darrow,Ulrike Gehring,Svetlana V. Glinianaia,Nelson Gouveia,Eun Hee Ha,Jong Han Leem,Edith H. van den Hooven,Bin Jalaludin,Bill M. Jesdale,Johanna Lepeule,Johanna Lepeule,Rachel Morello-Frosch,Geoffrey G. Morgan,Angela Cecilia Pesatori,Frank H. Pierik,Tanja Pless-Mulloli,David Q. Rich,Sheela Sathyanarayana,Ju Hee Seo,Rémy Slama,Matthew J. Strickland,Lillian Tamburic,Daniel Wartenberg,Mark J. Nieuwenhuijsen,Tracey J. Woodruff +29 more
TL;DR: Maternal exposure to particulate pollution was associated with LBW at term across study populations and three site characteristics and aspects of exposure assessment methodology appeared to contribute to the variation in associations reported by centers.
Journal ArticleDOI
Epigenome-Wide Meta-Analysis of Methylation in Children Related to Prenatal NO2 Air Pollution Exposure
Olena Gruzieva,Cheng-Jian Xu,Carrie V. Breton,Isabella Annesi-Maesano,Josep M. Antó,Charles Auffray,Charles Auffray,Charles Auffray,Stephane Ballereau,Stephane Ballereau,Tom Bellander,Jean Bousquet,Jean Bousquet,Mariona Bustamante,Marie-Aline Charles,Yvonne de Kluizenaar,Yvonne de Kluizenaar,Herman T. den Dekker,Herman T. den Dekker,Liesbeth Duijts,Liesbeth Duijts,Janine F. Felix,Janine F. Felix,Ulrike Gehring,Ulrike Gehring,Ulrike Gehring,Mònica Guxens,Mònica Guxens,Vincent V. W. Jaddoe,Soesma A Jankipersadsing,Simon Kebede Merid,Simon Kebede Merid,Juha Kere,Ashok Kumar,Nathanaël Lemonnier,Johanna Lepeule,Wenche Nystad,Christian M. Page,Sviatlana Panasevich,Dirkje S. Postma,Rémy Slama,Jordi Sunyer,Cilla Söderhäll,Jin Yao,Stephanie J. London,Göran Pershagen,Gerard H. Koppelman,Erik Melén +47 more
TL;DR: No2 exposure during pregnancy was associated with differential offspring DNA methylation in mitochondria-related genes and exposure to NO2 was also linked to differential methylation as well as expression of genes involved in antioxidant defense pathways.