J
Juan Carlos Fernández-López
Researcher at National Autonomous University of Mexico
Publications - 37
Citations - 7467
Juan Carlos Fernández-López is an academic researcher from National Autonomous University of Mexico. The author has contributed to research in topics: Population & Single-nucleotide polymorphism. The author has an hindex of 19, co-authored 31 publications receiving 6496 citations.
Papers
More filters
Journal ArticleDOI
The Mutational Landscape of Head and Neck Squamous Cell Carcinoma
Nicolas Stransky,Ann Marie Egloff,Aaron D. Tward,Aaron D. Tward,Aaron D. Tward,Aleksandar Kostic,Aleksandar Kostic,Kristian Cibulskis,Andrey Sivachenko,Gregory Kryukov,Gregory Kryukov,Michael S. Lawrence,Carrie Sougnez,Aaron McKenna,Erica Shefler,Alex H. Ramos,Petar Stojanov,Scott L. Carter,Douglas Voet,Maria L. Cortes,Daniel Auclair,Michael F. Berger,Gordon Saksena,Candace Guiducci,Robert C. Onofrio,Melissa Parkin,Marjorie Romkes,Joel L. Weissfeld,Raja R. Seethala,Lin Wang,Claudia Rangel-Escareño,Juan Carlos Fernández-López,Alfredo Hidalgo-Miranda,Jorge Melendez-Zajgla,Wendy Winckler,Kristin Ardlie,Stacey Gabriel,Matthew Meyerson,Eric S. Lander,Eric S. Lander,Eric S. Lander,Gad Getz,Todd R. Golub,Levi A. Garraway,Jennifer R. Grandis +44 more
TL;DR: In this article, the authors analyzed whole-exome sequencing data from 74 tumor-normal pairs and found that at least 30% of cases harbored mutations in genes that regulate squamous differentiation (for example, NOTCH1, IRF6, and TP63), implicating its dysregulation as a major driver of HNSCC carcinogenesis.
Journal ArticleDOI
Sequence analysis of mutations and translocations across breast cancer subtypes
Shantanu Banerji,Kristian Cibulskis,Claudia Rangel-Escareño,Kristin K. Brown,Scott L. Carter,Abbie M. Frederick,Michael S. Lawrence,Andrey Sivachenko,Carrie Sougnez,Lihua Zou,Maria L. Cortes,Juan Carlos Fernández-López,Shouyong Peng,Kristin G. Ardlie,Daniel Auclair,Verónica Bautista-Piña,Fujiko Duke,Joshua M. Francis,Joonil Jung,Antonio Maffuz-Aziz,Robert C. Onofrio,Melissa Parkin,Nam Pho,Valeria Quintanar-Jurado,Alex H. Ramos,Rosa Rebollar-Vega,Sergio Rodriguez-Cuevas,Sandra Romero-Cordoba,Steven E. Schumacher,Steven E. Schumacher,Nicolas Stransky,Kristin Thompson,Laura Uribe-Figueroa,José Baselga,Rameen Beroukhim,Rameen Beroukhim,Kornelia Polyak,Dennis C. Sgroi,Andrea L. Richardson,Gerardo Jimenez-Sanchez,Eric S. Lander,Eric S. Lander,Eric S. Lander,Stacey Gabriel,Levi A. Garraway,Levi A. Garraway,Todd R. Golub,Jorge Melendez-Zajgla,Alex Toker,Gad Getz,Alfredo Hidalgo-Miranda,Matthew Meyerson,Matthew Meyerson +52 more
TL;DR: Recurrent somatic mutations in PIK3CA, TP53, AKT1, GATA3 and MAP3K1 are confirmed and a recurrent MAGI3–AKT3 fusion enriched in triple-negative breast cancer lacking oestrogen and progesterone receptors and ERBB2 expression is identified.
Journal ArticleDOI
Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing
Jens G. Lohr,Petar Stojanov,Petar Stojanov,Michael S. Lawrence,Daniel Auclair,Bjoern Chapuy,Carrie Sougnez,Peter Cruz-Gordillo,Birgit Knoechel,Birgit Knoechel,Yan W. Asmann,Susan L. Slager,Anne J. Novak,Ahmet Dogan,Stephen M. Ansell,Brian K. Link,Lihua Zou,Joshua Gould,Gordon Saksena,Nicolas Stransky,Claudia Rangel-Escareño,Juan Carlos Fernández-López,Alfredo Hidalgo-Miranda,Jorge Melendez-Zajgla,Enrique Hernández-Lemus,Angela Schwarz-Cruz y Celis,Ivan Imaz-Rosshandler,Akinyemi I. Ojesina,Joonil Jung,Chandra Sekhar Pedamallu,Eric S. Lander,Eric S. Lander,Eric S. Lander,Thomas M. Habermann,James R. Cerhan,Margaret A. Shipp,Gad Getz,Todd R. Golub +37 more
TL;DR: It is shown that BCL2 mutations commonly occur in patients with BCL 2/IgH rearrangements as a result of somatic hypermutation normally occurring at the IgH locus, and an algorithm designed to identify likely functionally relevant but infrequent mutations is identified as likely drivers of DLBCL pathogenesis in some patients.
Journal ArticleDOI
Reconstructing Native American population history
David Reich,David Reich,Nick Patterson,Desmond Campbell,Desmond Campbell,Arti Tandon,Arti Tandon,Stéphane Mazières,Stéphane Mazières,Nicolas Ray,María Victoria Parra,María Victoria Parra,Winston Rojas,Winston Rojas,Constanza Duque,Constanza Duque,Natalia Mesa,Natalia Mesa,Luis F. García,Omar Triana,Silvia Blair,Amanda Maestre,Juan Carlos Dib,Claudio M. Bravi,Claudio M. Bravi,Graciela Bailliet,Daniel Corach,Tábita Hünemeier,Tábita Hünemeier,Maria Cátira Bortolini,Francisco M. Salzano,Maria Luiza Petzl-Erler,Victor Acuña-Alonzo,Carlos A. Aguilar-Salinas,Samuel Canizales-Quinteros,Teresa Tusié-Luna,Laura Riba,Maricela Rodríguez-Cruz,Mardia López-Alarcón,Ramón Mauricio Coral-Vázquez,Thelma Canto-Cetina,Irma Silva-Zolezzi,Juan Carlos Fernández-López,Alejandra V. Contreras,Gerardo Jimenez-Sanchez,María José Gómez-Vázquez,Julio Molina,Angel Carracedo,Antonio Salas,Carla Gallo,Giovanni Poletti,David B. Witonsky,Gorka Alkorta-Aranburu,Rem I. Sukernik,Ludmila P. Osipova,Sardana A. Fedorova,René Vasquez,Mercedes Villena,Claudia Moreau,Ramiro Barrantes,David L. Pauls,Laurent Excoffier,Laurent Excoffier,Gabriel Bedoya,Francisco Rothhammer,Jean-Michel Dugoujon,Georges Larrouy,William Klitz,Damian Labuda,Judith R. Kidd,Kenneth K. Kidd,Anna Di Rienzo,Nelson B. Freimer,Alkes L. Price,Alkes L. Price,Andres Ruiz-Linares +75 more
TL;DR: It is shown that the initial peopling followed a southward expansion facilitated by the coast, with sequential population splits and little gene flow after divergence, especially in South America.
Journal ArticleDOI
Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico
A. L. Williams Amy,A. L. Williams Amy,S. B R Jacobs Suzanne,Hortensia Moreno-Macías,Alicia Huerta-Chagoya,Claire Churchhouse,Carla Marquez-Luna,María José Gómez-Vázquez,N. P. Burtt Noël,Carlos A. Aguilar-Salinas,Clicerio Gonzalez-Villalpando,Jose C. Florez,Jose C. Florez,Lorena Orozco,Teresa Tusié-Luna,David Altshuler,David Altshuler,David Altshuler,Stephan Ripke,Stephan Ripke,Alisa K. Manning,Humberto García-Ortiz,Benjamin M. Neale,Benjamin M. Neale,David Reich,David Reich,Daniel O. Stram,Juan Carlos Fernández-López,Sandra Romero-Hidalgo,Nick Patterson,Christopher A. Haiman,Irma Aguilar-Delfín,Angélica Martínez-Hernández,Federico Centeno-Cruz,Elvia Mendoza-Caamal,Cristina Revilla-Monsalve,Sergio Islas-Andrade,Emilio J. Cordova,Eunice Rodríguez-Arellano,Xavier Soberón,J. C. Florez Jose,J. C. Florez Jose,M. A. González-Villalpando María Elena,Brian E. Henderson,Kristine R. Monroe,Lynne R. Wilkens,Laurence N. Kolonel,Loic Le Marchand,Laura Riba,M. A. Ordóñez-Sánchez María Luisa,Rosario Rodríguez-Guillén,Ivette Cruz-Bautista,Maribel Rodríguez-Torres,Linda Liliana Muñoz-Hernandez,Tamara Sáenz,Donají Gómez,Ulices Alvirde,Robert C. Onofrio,Wendy Brodeur,Diane Gage,Jacquelyn Murphy,Jennifer Franklin,Scott Mahan,Kristin G. Ardlie,Andrew Crenshaw,Wendy Winckler,Kay Prüfer,Michael V. Shunkov,Susanna Sawyer,Udo Stenzel,Janet Kelso,Monkol Lek,Monkol Lek,Sriram Sankararaman,Sriram Sankararaman,Daniel G. MacArthur,Daniel G. MacArthur,A.P. Derevianko,Svante Pääbo,Suzanne B.R. Jacobs,Shuba Gopal,James A. Grammatikos,Ian Smith,Kevin Bullock,Amy Deik,Amanda Souza,Kerry A. Pierce,Clary B. Clish,Timothy Fennell,Yossi Farjoun,Stacey Gabriel,Myron D. Gross,Mark A. Pereira,Mark Seielstad,Woon-Puay Koh,E. Shyong Tai,Jason Flannick,Jason Flannick,Pierre Fontanillas,Andrew D. Morris,Tanya M. Teslovich,Gil Atzmon,John Blangero,Donald W. Bowden,John C. Chambers,John C. Chambers,Yoon Shin Cho,Ravindranath Duggirala,Benjamin Glaser,Benjamin Glaser,Craig L. Hanis,Jaspal S. Kooner,Jaspal S. Kooner,Markku Laakso,Jong-Young Lee,Yik Ying Teo,Yik Ying Teo,James G. Wilson,Sobha Puppala,Vidya S. Farook,Farook Thameem,Hanna E. Abboud,Ralph A. DeFronzo,Christopher P. Jenkinson,Donna M. Lehman,Joanne E. Curran,Maria L. Cortes,C. González-Villalpando Clicerio,L. Orozco Lorena +128 more
TL;DR: Analysis in Mexican and Latin American individuals identified SLC16A11 as a novel candidate gene for type 2 diabetes with a possible role in triacylglycerol metabolism and an archaic genome sequence indicated that the risk haplotype introgressed into modern humans via admixture with Neanderthals.