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Kaixian Chen

Researcher at Chinese Academy of Sciences

Publications -  403
Citations -  11476

Kaixian Chen is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Virtual screening & Chemistry. The author has an hindex of 47, co-authored 380 publications receiving 9209 citations. Previous affiliations of Kaixian Chen include Shanghai University & East China University of Science and Technology.

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Capturing intercellular sugar-mediated ligand-receptor recognitions via a simple yet highly biospecific interfacial system

Zhen Li, +11 more
- 29 Jul 2013 - 
TL;DR: It is shown that an electroactive interface confined with densely clustered galactosyl ligands is able to ingeniously recognize the asialoglycoprotein receptors on live Hep-G2 cells employing simple electrochemical techniques.
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The Dipeptide H-Trp-Glu-OH Shows Highly Antagonistic Activity against PPARγ: Bioassay with Molecular Modeling Simulation

Fei Ye, +8 more
- 09 Jan 2006 - 
TL;DR: The dipeptide H‐Trp‐Glu‐OH (G3335) was discovered to be a novel PPARγ antagonist and the results suggested that residues Cys285, Arg288, Ser289, and His449 in PParγ play vital roles inPPARγ‐LBD–G33 35 binding.
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Molecular docking and 3D QSAR studies on 1-amino-2-phenyl-4-(piperidin-1-yl)-butanes based on the structural modeling of human CCR5 receptor.

Yong Xu, +7 more
- 01 Dec 2004 - 
TL;DR: The 3D model of CCR5 can be used in structure-based drug design and the 3D QSAR models provide clear guidelines and accurate activity predictions for novel antagonist design, and suggest that the 3d model of antagonist-CCR5 interaction is reliable.
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Novel cyclophilin D inhibitors derived from quinoxaline exhibit highly inhibitory activity against rat mitochondrial swelling and Ca2+ uptake/ release.

Hongxia Guo, +9 more
- 01 Oct 2005 - 
TL;DR: Its potent ability to inhibit mitochondrial swelling and the binding selectivity of GW5 indicates that GW5 could potentially be used for inhibiting MPT pore opening.
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Effect of cation–π interaction on NMR: A theoretical investigation on complexes of Li+, Na+, Be2+, and Mg2+ with aromatics

Jiagao Cheng, +7 more
- 10 May 2006 - 
TL;DR: In this paper, density functional theory calculations were performed on 16 cationπ complexes formed by cations of Li+, Na+, Be2+, and Mg2+ and π systems of benzene, 1,3,5-trifluorobenzene (TFBZ), 1, 3, 5-trimethylbenzene (TMOBZ), and 1.3, 5trimethoxybenzenes (TLBZ) for all substituted aromatics.