K
Kaixian Chen
Researcher at Chinese Academy of Sciences
Publications - 403
Citations - 11476
Kaixian Chen is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Virtual screening & Chemistry. The author has an hindex of 47, co-authored 380 publications receiving 9209 citations. Previous affiliations of Kaixian Chen include Shanghai University & East China University of Science and Technology.
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Mutagenic probability estimation of chemical compounds by a novel molecular electrophilicity vector and support vector machine
TL;DR: A novel molecular electrophilicity vector is first devised to represent the structure profile of chemical compounds and an extended support vector machine (SVM) method is used to derive the posterior probabilistic estimation of mutagenicity from the MEVs of the training set.
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Smart Tumor Microenvironment-Responsive Nanotheranostic Agent for Effective Cancer Therapy
Shiyan Guo,Shiyan Guo,Di Sun,Dalong Ni,Miaorong Yu,Kun Qian,Wei Zhang,Yiwei Yang,Sha Song,Yang Li,Ziyue Xi,Jie Wang,Jingyi Li,Yan Wei,Kaixian Chen,Kaixian Chen,Yong Gan,Zhengtao Wang +17 more
TL;DR: In vivo pharmacodynamics results demonstrate that these synergetic effects caused by CaM‐PB NPs significantly contribute to the inhibition of tumor progression, demonstrating that theCaM‐ PB NPs with sequential theranostic functions are a promising system for effective cancer therapy.
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Pyrazolidine-3,5-dione derivatives as potent non-steroidal agonists of farnesoid X receptor: virtual screening, synthesis, and biological evaluation.
TL;DR: The novel structural scaffold has provided a new direction for finding potent and selective FXR partial and full agonists (referred to as 'selective bile acid receptor modulators', SBARMs).
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Dual role of Zn2+ in maintaining structural integrity and suppressing deacetylase activity of SIRT1.
Lei Chen,Yu Feng,Yinqiu Zhou,Weiliang Zhu,Xu Shen,Kaixian Chen,Hualiang Jiang,Hualiang Jiang,Dongxiang Liu +8 more
TL;DR: The results indicate that Zn(2+) plays a dual role in SIRT1 activity and may also bind to another site different from the zinc-finger motif or the binding sites for the substrates or resveratrol and act as a potent inhibitor of SIRT2.
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Benzbromarone, an old uricosuric drug, inhibits human fatty acid binding protein 4 in vitro and lowers the blood glucose level in db/db mice
Cai Haiyan,Ting Wang,Jian-chun Zhao,Peng Sun,Guirui Yan,Hai-Peng Ding,Yingxia Li,He-Yao Wang,Weiliang Zhu,Kaixian Chen +9 more
TL;DR: Oral administration of BBR dose-dependently reduced the blood glucose level and improved glucose tolerance and insulin resistance in db/db mice and revealed that the residues Ser55, Asp76, and Arg126 of FABP4 formed important interactions with BBR, which was confirmed by site-directed mutagenesis studies.