K
Kaixian Chen
Researcher at Chinese Academy of Sciences
Publications - 403
Citations - 11476
Kaixian Chen is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Virtual screening & Chemistry. The author has an hindex of 47, co-authored 380 publications receiving 9209 citations. Previous affiliations of Kaixian Chen include Shanghai University & East China University of Science and Technology.
Papers
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Journal ArticleDOI
Discovery of alkoxy benzamide derivatives as novel BPTF bromodomain inhibitors via structure-based virtual screening
Dan Zhang,Jie Han,Wenchao Lu,Fulin Lian,Jun Wang,Tian Lu,Hongru Tao,Senhao Xiao,Fengcai Zhang,Yu-Chih Liu,Rongfeng Liu,Naixia Zhang,Hualiang Jiang,Kaixian Chen,Chun-shen Zhao,Cheng Luo +15 more
TL;DR: By integrating docking-based virtual screening with biochemical analysis, this study identified a novel selective BPTF bromodomain inhibitor DCB29 with the IC50 value of 13.2 ± 1.6 μM by homogenous time-resolved fluorescence resonance energy transfer (HTRF) assays and presented great potential as a powerful tool for BPTF-related biological research and further medicinal chemistry optimization.
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A conserved hydrophobic core at Bcl-xL mediates its structural stability and binding affinity with BH3-domain peptide of pro-apoptotic protein
Yu Feng,Liang Zhang,Tianchen Hu,Xu Shen,Xu Shen,Jianping Ding,Kaixian Chen,Hualiang Jiang,Hualiang Jiang,Dongxiang Liu +9 more
TL;DR: The BH3-domain peptide binding affinity and pore forming propensity of Bcl-x(L) were correlated to its death-repressor activity, which provides new information to help study the regulatory mechanism of anti-apoptotic proteins.
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Discovery of potent DOT1L inhibitors by AlphaLISA based High Throughput Screening assay.
Yakai Song,Linjuan Li,Yantao Chen,Jingqiu Liu,Senhao Xiao,Fulin Lian,Naixia Zhang,Hong Ding,Yuanyuan Zhang,Kaixian Chen,Hualiang Jiang,Chenhua Zhang,Yu-Chih Liu,Shijie Chen,Cheng Luo +14 more
TL;DR: A HTS platform based on AlphaLISA method for screening and discovery of DOT1L novel inhibitor is developed, through which compound 3 and its analogues as potent DOT1l inhibitors with promising MLL-rearranged leukemia therapeutic application are discovered.
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Combinatorial Pharmacophore Modeling of Multidrug and Toxin Extrusion Transporter 1 Inhibitors: a Theoretical Perspective for Understanding Multiple Inhibitory Mechanisms
Yuan Xu,Xian Liu,Yulan Wang,Nannan Zhou,Jianlong Peng,Likun Gong,Jing Ren,Cheng Luo,Xiaomin Luo,Hualiang Jiang,Hualiang Jiang,Kaixian Chen,Kaixian Chen,Mingyue Zheng +13 more
TL;DR: A combinatorial pharmacophore (CP) model for Multidrug and toxin extrusion 1 (MATE1/SLC47A1) inhibitors was developed based on a data set including 881 compounds and indicated that the small inhibitors matching HHR1 and DRR involve in competitive inhibition, while the relatively large inhibitors matching AAAP are responsible for the noncompetitive inhibition by locking the conformation changing of MATE1.
Journal ArticleDOI
Outline Design of ITER Radial X-Ray Camera Diagnostic
Liqun Hu,Kaixian Chen,Chen Yebin,Shaojun Li,Jiangang Shen,Sheng Xiuli,Niu Luying,Ya Cheng,Jinlong Zhao +8 more
TL;DR: The radial X-ray camera (RXC) as mentioned in this paper was designed to measure the poloidal profile of plasma Xray emission with high spatial and temporal resolution, and its primary diagnostic role includes measuring low (m,...