K
Kaixian Chen
Researcher at Chinese Academy of Sciences
Publications - 403
Citations - 11476
Kaixian Chen is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Virtual screening & Chemistry. The author has an hindex of 47, co-authored 380 publications receiving 9209 citations. Previous affiliations of Kaixian Chen include Shanghai University & East China University of Science and Technology.
Papers
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Journal ArticleDOI
Rapid and Efficient Pd-Catalyzed Sonogashira Coupling of Aryl Chlorides.
TL;DR: An efficient and effective microwave-assisted cross-coupling of terminal alkynes with various aryl chlorides including sterically hindered, electron-rich, electron neutral, and electron-deficient is developed in this article.
Posted ContentDOI
Computational target fishing by mining transcriptional data using a novel Siamese spectral-based graph convolutional network
Feisheng Zhong,Xiaolong Wu,Xiaolong Wu,Xutong Li,Dingyan Wang,Zunyun Fu,Zunyun Fu,Xiaohong Liu,Xiaohong Liu,Xiaozhe Wan,Tianbiao Yang,Xiaomin Luo,Kaixian Chen,Hualiang Jiang,Hualiang Jiang,Mingyue Zheng +15 more
TL;DR: A novel Siamese spectral-based graph convolutional network model for inferring the protein targets of chemical compounds from gene transcriptional profiles that was successfully trained to learn from known compound-target pairs by uncovering the hidden correlations between compound perturbation profiles and gene knockdown profiles.
Journal Article
[A new practical route to stereospecific synthesis of (S)-(-)-ofloxacin].
Yang Ys,Ji Ry,Hu Z,Kaixian Chen +3 more
TL;DR: A new facile practical route with good yield and high optical purity to stereospecific synthesis of (S)-(-)-ofloxacin was described.
Journal Article
Binding conformers searching method for ligands according to the structures of their receptors and its application to thrombin inhibitors.
TL;DR: Both of the total binding energies and steric binding energies have good correlations with the inhibitory activities of these thrombin inhibitors, demonstrating that the binding conformer searching method for ligands is reasonable.
Patent
Benzopyranone derivatives and their use as anti-coronaviral agents
Chum Mok Puah,Weiliang Zhu,Jian Li,Lili Chen,Cheng Luo,Gang Chen,Zhili Zuo,Xiaomin Luo,Xu Shen,Kaixian Chen,Hualiang Jiang +10 more
TL;DR: In this article, pharmaceutical compositions comprising benzopyranone derivatives for the treatment of Severe Acute Respiratory Syndrome (SARS) were described. But none of the compositions were tested on humans.