K
Kaixian Chen
Researcher at Chinese Academy of Sciences
Publications - 403
Citations - 11476
Kaixian Chen is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Virtual screening & Chemistry. The author has an hindex of 47, co-authored 380 publications receiving 9209 citations. Previous affiliations of Kaixian Chen include Shanghai University & East China University of Science and Technology.
Papers
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Journal ArticleDOI
Discovery of 2-substituted-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide as potent and selective protein arginine methyltransferases 5 inhibitors: Design, synthesis and biological evaluation.
Jingwei Shao,Kongkai Zhu,Daohai Du,Yuanyuan Zhang,Hongrui Tao,Zhifeng Chen,Hualiang Jiang,Kaixian Chen,Cheng Luo,Wenhu Duan +9 more
TL;DR: A series of N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)amide derivatives targeting PRMT5 were designed with structure-based approach and synthesized and showed potent and selectivePRMT5 inhibition activity with an IC50 of 8.5 nM.
Journal ArticleDOI
Alkaloid Enantiomers from the Roots of Isatis indigotica.
Dongdong Zhang,Yanhong Shi,Rui Xu,Kang Du,Fujiang Guo,Kaixian Chen,Kaixian Chen,Yiming Li,Rui Wang +8 more
TL;DR: Alkaloids 1a and 1b possess an unpresented carbon skeleton and their putative biosynthetic pathways are discussed, and all of the alkaloids were tested for their nitric oxide inhibitory effects in RAW 264.7 cells.
Journal ArticleDOI
Discovery of High-Affinity Inhibitors of the BPTF Bromodomain.
Tian Lu,Tian Lu,Tian Lu,Haibo Lu,Haibo Lu,Zhe Duan,Zhe Duan,Jun Wang,Jie Han,Senhao Xiao,HuanHuan Chen,Hao Jiang,Yu Chen,Feng Yang,Qi Li,Dongying Chen,Jin Lin,Bo Li,Hualiang Jiang,Kaixian Chen,Kaixian Chen,Wenchao Lu,Hua Lin,Hua Lin,Cheng Luo +24 more
TL;DR: In this paper, the structural decomposition of the reported PHD finger transcription factor (BPTF) inhibitor TP-238 was synthetically modified to obtain the lead compound DC-BPi-03, which was identified as a novel BPTF-BRD inhibitor with a moderate potency.
Journal Article
Mapping Central α-Helix Linker Mediated Conformational Transition Pathway of Calmodulin via Simple Computational Approach B
Jinan Wang,Shaoliang Peng,Benjamin P. Cossins,Xiangke Liao,Kaixian Chen,Qiang Shao,Xiaoqian Zhu,Jiye Shi,Weiliang Zhu +8 more
TL;DR: In this article, the effects of intrinsic structural flexibility of calmodulin protein on the mechanism of its allosteric conformational transition are investigated using a novel in silico approach.
Journal ArticleDOI
Identification of Novel Small Molecules as Inhibitors of Hepatitis C Virus by Structure-Based Virtual Screening
Jing Li,Xian Liu,Shanshan Li,Yulan Wang,Nannan Zhou,Cheng Luo,Xiaomin Luo,Mingyue Zheng,Hualiang Jiang,Kaixian Chen +9 more
TL;DR: In this study, sixteen novel compounds with cell-based HCV replicon activity ranging from 3.0 to 28.2 μM (IC50) were successfully identified by means of structure-based virtual screening, and compound 5 and compound 11 are the two most potent molecules with low cytotoxicity.