Kaixian Chen

TL;DR: The chemical tractability of the difficult PPI target by a small molecule compound is demonstrated, highlighting the therapeutic promise for PRC2-driven human cancers via targeted destruction of the EZH2-EED complex.

TL;DR: A new aroE gene encoding SDH from Helicobacter’s strain SS1 is identified and expected to favor better understanding the features of SDH and provide useful information for the development of novel antibiotics to treat H.’pylori‐associated infection.

TL;DR: In this article, the authors performed density functional theory (DFT) calculations at the B3LYP/6-311++G(d,p) level to systematically explore the geometrical multiplicity and binding strength for the complexes formed by alkaline and alkaline earth metal cations, viz. Li+, Na+, K+, Be2+, Mg2+, and Ca2+ (Mn+, hereinafter), with nucleobases, namely, adenine, cytosine, guanine, thymine, and uracil.

TL;DR: Two new technologies of CADD associated with target identification and new chemical entity discovery will be the focus of this review.

TL;DR: This study has provided some insights into the catalytic and inhibitory mechanisms of FabZ, thus facilitating antibacterial agent development, and its complexes with two newly discovered inhibitors have been solved.