K
Kaixian Chen
Researcher at Chinese Academy of Sciences
Publications - 403
Citations - 11476
Kaixian Chen is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Virtual screening & Chemistry. The author has an hindex of 47, co-authored 380 publications receiving 9209 citations. Previous affiliations of Kaixian Chen include Shanghai University & East China University of Science and Technology.
Papers
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Journal ArticleDOI
New p-methylsulfonamido phenylethylamine analogues as class III antiarrhythmic agents: design, synthesis, biological assay, and 3D-QSAR analysis.
Hong Liu,Ming Ji,Xiaomin Luo,Jianhua Shen,Xiaoqin Huang,Weiyi Hua,Hualiang Jiang,Kaixian Chen +7 more
TL;DR: The results showed that the 3D-QSAR models are reliable and can be extended to design new antiarrhythmic agents and could describe the steric, electrostatic, and hydrophobic requirements for recognition forces of the receptor site.
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A model molecule study of the O-centered and the C-centered free radical intermediates of artemisinin
TL;DR: In this paper, the 6,7,8-trioxybicyclo[3,2,2]nonane has been used as a model molecule for the anti-malarial drug artemisinin.
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Inhibitory mode of indole-2-carboxamide derivatives against HLGPa: molecular docking and 3D-QSAR analyses.
Guixia Liu,Zhenshan Zhang,Xiaomin Luo,Jianhua Shen,Hong Liu,Xu Shen,Kaixian Chen,Hualiang Jiang +7 more
TL;DR: In this paper, a series of indole-2-carboxamide compounds with human liver glycogen phosphorylase a (HLGPa) have been studied employing molecular docking and 3D-QSAR approaches.
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Indole alkaloid glycosides from Isatis tinctoria roots.
Dongdong Zhang,Kang Du,Yitian Zhao,Songshan Shi,Yingchun Wu,Qi Jia,Kaixian Chen,Kaixian Chen,Yiming Li,Rui Wang +9 more
TL;DR: Two new indole alkaloid glycoside glycosides along with five known ones were obtained from the roots of I. tinctoria and showed inhibitory effects against LPS-stimulated RAW 264.7 cells.
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Combinatorial pharmacophore modeling of organic cation transporter 2 (OCT2) inhibitors: insights into multiple inhibitory mechanisms.
Yuan Xu,Xian Liu,Shanshan Li,Nannan Zhou,Likun Gong,Cheng Luo,Xiaomin Luo,Mingyue Zheng,Hualiang Jiang,Hualiang Jiang,Kaixian Chen +10 more
TL;DR: A combinatorial scheme to screen the optimum combination of pharmacophores from a pool of hypotheses established based on 162 OCT2 inhibitors found that the number of matched hypotheses was positively correlated with inhibition rate, which coincides with the pharmacophore modeling result of P-gp substrate binding.