K
Kaixian Chen
Researcher at Chinese Academy of Sciences
Publications - 403
Citations - 11476
Kaixian Chen is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Virtual screening & Chemistry. The author has an hindex of 47, co-authored 380 publications receiving 9209 citations. Previous affiliations of Kaixian Chen include Shanghai University & East China University of Science and Technology.
Papers
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Journal ArticleDOI
Discovery and characterization of a novel cGAS covalent inhibitor for the treatment of inflammatory bowel disease
Jiaqi Song,Ruirui Yang,Jie Chang,Ya-Dan Liu,Cheng-Hao Lu,Li Fan Chen,Hao Guo,Yinghui Zhang,Zi-sheng Fan,Jing Yi Zhou,Guiyuan Zhou,Keke Zhang,Xiaomin Luo,Kaixian Chen,Hualiang Jiang,Sulin Zhang,Mingyue Zheng +16 more
TL;DR: The discovery and identification of several novel types of cGAS inhibitors by pyrophosphatase (PPiase)-coupled activity assays are reported, with 1-(1-phenyl-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-2-yl)prop-2
Journal ArticleDOI
The application of artificial intelligence to drug sensitivity prediction
Xutong Li,Xiaolong Wu,Xiaolong Wu,Xiaozhe Wan,Feisheng Zhong,Chen Cui,Yingjia Chen,Lifan Chen,Kaixian Chen,Hualiang Jiang,Mingyue Zheng +10 more
TL;DR: In this article, the authors summarize the characteristics of publicly accessible genomic databases and discuss the trends of artificial intelligence applications in drug sensitivity prediction for cancer cell lines, including machine learning, networks and multimodal deep neural networks.
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Design, Synthesis, and Bioevaluation of Pyrido[2,3-d]pyrimidin-7-ones as Potent SOS1 Inhibitors.
Meiying Liu,Guizhen Zhou,Wenhong Su,Yuejiao Gu,Ming-Mei Gao,Kun Sheng Wang,Ruifeng Huo,Yupeng Li,Zehui Zhou,Kaixian Chen,Mingyue Zheng,Sulin Zhang,Tianfeng Xu +12 more
TL;DR: In this paper , a series of new guanine nucleotide exchange factor SOS1 inhibitors with the pyrido[2,3-d]pyrimidin-7-one scaffold were designed and synthesized.
Journal Article
Recent development in quinolone compounds antitumor quinolones
Yang Ys,Zhao,Ji Ry,Kaixian Chen +3 more
Journal ArticleDOI
One step stereoselective synthesis of oxazoline-fused saccharides and their conversion into the corresponding 1,2-cis glycosylamines bearing various protected groups.
Sanfeng Dong,Sanfeng Dong,Yitian Zhao,Yitian Zhao,Yulong Shi,Zhijian Xu,Jingshan Shen,Qi Jia,Yiming Li,Kaixian Chen,Kaixian Chen,Bo Li,Weiliang Zhu,Weiliang Zhu +13 more
TL;DR: In this paper, a straightforward synthesis of oxazoline-fused saccharides (oxazolinoses) from peracetylated and benzonitriles under acidic conditions with stoichiometric amounts of water was revealed.