K
Kaixian Chen
Researcher at Chinese Academy of Sciences
Publications - 403
Citations - 11476
Kaixian Chen is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Virtual screening & Chemistry. The author has an hindex of 47, co-authored 380 publications receiving 9209 citations. Previous affiliations of Kaixian Chen include Shanghai University & East China University of Science and Technology.
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Seven New Sesquiterpene Lactones from Eupatorium chinense
TL;DR: In this article, seven new sesquiterpenoids, namely eupatochinilides I-VII (1, 7), together with eight known compounds, euponin (8), mollisorin A (9), niveusin B (10), 8β-(4′,acetoxy-tiglyloxy)-3β -hydroxy-6Hβ,7Hα-germacra-1(10)E,4E,11(13)-trien-6,12-olide (11), e
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Pyrene Excimer‐based Bis‐triazolyl Pyranoglycoligands as Specific Mercury Sensors
TL;DR: New C3,4-disubstituted bis-triazolyl glycoligands that feature a glucosyl or galactosyl scaffold incorporating two pyrenyl groups were synthesized via the CuI-catalyzed azide-alkyne 1,3-dipolar cycloaddition reaction (Cue-AAC).
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Density functional theory (DFT) study on the interaction of ammonium (NH4+) and aromatic nitrogen heterocyclics
TL;DR: In this article, a DFT calculation was performed at the B3LYP/6-31G* level on the complexes formed by NH4+ and aromatic nitrogen heterocyclics, viz. pyrrole, imidazole, pyridine and indole, in order to investigate the mechanism and complexity of the interaction between the ammonium group and the aromatic ring structure in biomacromolecules.
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Discovery of Novel Inhibitors Targeting the Menin-Mixed Lineage Leukemia Interface Using Pharmacophore- and Docking-Based Virtual Screening
Yuan Xu,Liyan Yue,Yulan Wang,Jing Xing,Zhifeng Chen,Zhe Shi,Rongfeng Liu,Yu-Chih Liu,Xiaomin Luo,Hualiang Jiang,Hualiang Jiang,Kaixian Chen,Kaixian Chen,Cheng Luo,Mingyue Zheng +14 more
TL;DR: This work aims to discover novel inhibitors targeting the menin-MLL interface with virtual screening and establishes structure-based molecular docking and ligand-based pharmacophore models that show a remarkable ability to retrieve known active ligands from decoy molecules.
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Inhibition of autophagy by a small molecule through covalent modification of LC3
Cheng Luo,Shijie Fan,Liyan Yue,Wei Wan,Yuanyuan Zhang,Bidong Zhang,Chinatsu Otomo,Quanfu Li,Lin Tingting,Junchi Hu,Pan Xu,Mingrui Zhu,Hongru Tao,Zhifeng Chen,Lianchun Li,Hong Ding,Zhiyi Yao,Junyan Lu,Yi Wen,Naixia Zhang,Minjia Tan,Kaixian Chen,Xie Yuli,Takanori Otomo,Bing Zhou,Hualiang Jiang,Yongjun Dang +26 more
TL;DR: In this article, a small molecule modulator of LC3A/B that covalently modifies LC3B protein at Lys49 was discovered, which could serve as a powerful tool for autophagy research as well as for therapeutic interventions.