L
Linda J. Van Eldik
Researcher at Vanderbilt University
Publications - 31
Citations - 1744
Linda J. Van Eldik is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Calmodulin & Calcium-binding protein. The author has an hindex of 18, co-authored 31 publications receiving 1639 citations. Previous affiliations of Linda J. Van Eldik include University of Washington & Centre national de la recherche scientifique.
Papers
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Journal ArticleDOI
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis
David C. Whitcomb,Jessica LaRusch,Alyssa M. Krasinskas,Lambertus Klei,Jill P. Smith,Randall E. Brand,John P. Neoptolemos,Markus M. Lerch,Matt Tector,Bimaljit S. Sandhu,Nalini M. Guda,Lidiya Orlichenko,Samer Alkaade,Stephen T. Amann,Michelle A. Anderson,John Baillie,Peter A. Banks,Darwin L. Conwell,Gregory A. Cote,Peter B. Cotton,James A. DiSario,Lindsay A. Farrer,Chris E. Forsmark,Marianne Johnstone,Timothy B. Gardner,Andres Gelrud,William Greenhalf,Jonathan L. Haines,Douglas J. Hartman,Robert A. Hawes,Christopher Lawrence,Michele D. Lewis,Julia Mayerle,Richard Mayeux,Nadine M. Melhem,Mary E. Money,Thiruvengadam Muniraj,Georgios I. Papachristou,Margaret A. Pericak-Vance,Joseph Romagnuolo,Gerard D. Schellenberg,Stuart Sherman,Peter Simon,Vijay P. Singh,Adam Slivka,Donna B. Stolz,Robert Sutton,Frank Ulrich Weiss,C. Mel Wilcox,Narcis O. Zarnescu,Stephen R. Wisniewski,Michael R. O'Connell,Michelle L. Kienholz,Kathryn Roeder,M. Michael Barmada,Dhiraj Yadav,Bernie Devlin,Marilyn S. Albert,Roger L. Albin,Roger L. Albin,Liana G. Apostolova,Steven E. Arnold,Clinton T. Baldwin,Robert Barber,Lisa L. Barnes,Thomas G. Beach,Gary W. Beecham,Duane Beekly,David A. Bennett,Eileen H. Bigio,Thomas D. Bird,Deborah Blacker,Adam L. Boxer,James R. Burke,Joseph D. Buxbaum,Nigel J. Cairns,Laura B. Cantwell,Chuanhai Cao,Regina M. Carney,Steven L. Carroll,Helena C. Chui,David G. Clark,David H. Cribbs,Elizabeth Crocco,Carlos Cruchaga,Charles DeCarli,F. Yesim Demirci,Malcolm B. Dick,Dennis W. Dickson,Ranjan Duara,Nilufer Ertekin-Taner,Kelley Faber,Kenneth B. Fallon,Martin R. Farlow,Steven H. Ferris,Tatiana Foroud,Matthew P. Frosch,Douglas Galasko,Mary Ganguli,Marla Gearing,Daniel H. Geschwind,Bernardino Ghetti,John R. Gilbert,Sid Gilman,Jonathan D. Glass,Alison Goate,Neill R. Graff-Radford,Robert C. Green,John H. Growdon,Hakon Hakonarson,Kara L. Hamilton-Nelson,Ronald L. Hamilton,Lindy E. Harrell,Elizabeth Head,Lawrence S. Honig,Christine M. Hulette,Bradley T. Hyman,Gregory A. Jicha,Lee-Way Jin,Gyungah Jun,M. Ilyas Kamboh,Anna Karydas,Jeffrey Kaye,Jeffrey Kaye,Ronald C. Kim,Edward H. Koo,Neil W. Kowall,Joel H. Kramer,Patricia L. Kramer,Walter A. Kukul,Frank M. LaFerla,James J. Lah,James B. Leverenz,Allan I. Levey,Ge Li,Chiao-Feng Lin,Andrew P. Lieberman,Oscar L. Lopez,Kathryn L. Lunetta,Constantine G. Lyketsos,Wendy J. Mack,Daniel C. Marson,Eden R. Martin,Frank Martiniuk,Deborah C. Mash,Eliezer Masliah,Ann C. McKee,M.-Marsel Mesulam,Bruce L. Miller,Carol A. Miller,Joshua W. Miller,Thomas J. Montine,John C. Morris,Jill R. Murrel,Adam C. Naj,Adam C. Naj,John M Olichney,Joseph E. Parisi,Elaine R. Peskind,Ronald C. Petersen,Aimee Pierce,Wayne W. Poon,Huntington Potter,Joseph F. Quinn,Ashok Raj,Murray A. Raskind,Eric M. Reiman,Barry Reisberg,Christiane Reitz,John M. Ringman,Erik D. Roberson,Howard J. Rosen,Roger N. Rosenberg,Mary Sano,Andrew J. Saykin,Julie A. Schneider,Lon S. Schneider,William W. Seeley,Amanda Smith,Joshua A. Sonnen,Salvatore Spina,Robert S. Stern,Rudolph E. Tanzi,John Q. Trojanowski,Juan C. Troncoso,Juan C. Troncoso,Debby W. Tsuang,Otto Valladares,Vivianna M. Van Deerlin,Linda J. Van Eldik,Badri N. Vardarajan,Harry V. Vinters,Jean Paul Vonsatte,Li-San Wang,Sandra Weintraub,Kathleen A. Welsh-Bohmer,Jennifer Williamson,Randall L. Woltjer,Clinton B. Wright,Steven G. Younkin,Chang En Yu,Lei Yu +201 more
TL;DR: Two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 are reported and could partially explain the high frequency of alcohol-related pancreatitis in men.
Book ChapterDOI
Calcium-Binding Proteins and the Molecular Basis of Calcium Action
TL;DR: This chapter discusses the ways in which calcium is bound to a protein as well as the role of calcium in protein function, and the proposed roles for calcium and the postulated calcium-binding sites are based on homology with concanavalin A (Con A).
Journal ArticleDOI
Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.
Adam C. Naj,Gyungah Jun,Christiane Reitz,Brian W. Kunkle,William Perry,YoSon Park,Gary W. Beecham,Gary W. Beecham,Ruchita Rajbhandary,Kara L. Hamilton-Nelson,Li-San Wang,John S. K. Kauwe,Matthew J. Huentelman,Amanda J. Myers,Thomas D. Bird,Thomas D. Bird,Bradley F. Boeve,Clinton T. Baldwin,Gail P. Jarvik,Paul K. Crane,Ekaterina Rogaeva,M. Michael Barmada,F. Yesim Demirci,Carlos Cruchaga,Patricia L. Kramer,Nilufer Ertekin-Taner,John Hardy,Neill R. Graff-Radford,Robert C. Green,Eric B. Larson,Eric B. Larson,Peter St George-Hyslop,Peter St George-Hyslop,Joseph D. Buxbaum,Denis A. Evans,Julie A. Schneider,Kathryn L. Lunetta,M. Ilyas Kamboh,Andrew J. Saykin,Eric M. Reiman,Philip L. De Jager,Philip L. De Jager,David A. Bennett,John C. Morris,Thomas J. Montine,Alison Goate,Deborah Blacker,Debby W. Tsuang,Debby W. Tsuang,Hakon Hakonarson,Walter A. Kukull,Tatiana Foroud,Eden R. Martin,Eden R. Martin,Jonathan L. Haines,Richard Mayeux,Lindsay A. Farrer,Gerard D. Schellenberg,Margaret A. Pericak-Vance,Margaret A. Pericak-Vance,Marilyn S. Albert,Roger L. Albin,Liana G. Apostolova,Steven E. Arnold,Robert Barber,Lisa L. Barnes,Thomas G. Beach,James T. Becker,Duane Beekly,Eileen H. Bigio,James D. Bowen,Adam L. Boxer,James R. Burke,Nigel J. Cairns,Laura B. Cantwell,Chuanhai Cao,Christopher S. Carlson,Regina M. Carney,Minerva M. Carrasquillo,Steven L. Carroll,Helena C. Chui,David G. Clark,Jason J. Corneveaux,David H. Cribbs,Elizabeth Crocco,Charles DeCarli,Steven T. DeKosky,Malcolm B. Dick,Dennis W. Dickson,Ranjan Duara,Kelley Faber,Kenneth B. Fallon,Martin R. Farlow,Steven H. Ferris,Matthew P. Frosch,Douglas Galasko,Mary Ganguli,Marla Gearing,Daniel H. Geschwind,Bernardino Ghetti,John R. Gilbert,Jonathan D. Glass,Jonathan D. Glass,John H. Growdon,Ronald L. Hamilton,Lindy E. Harrell,Elizabeth Head,Lawrence S. Honig,Christine M. Hulette,Bradley T. Hyman,Gregory A. Jicha,Lee-Way Jin,Anna Karydas,Jeffrey Kaye,R. C. Kim,R. C. Kim,Edward H. Koo,Neil W. Kowall,Joel H. Kramer,Frank M. LaFerla,James J. Lah,James B. Leverenz,Allan I. Levey,Ge Li,Andrew P. Lieberman,Chiao-Feng Lin,Oscar L. Lopez,Constantine G. Lyketsos,Wendy J. Mack,Frank Martiniuk,Deborah C. Mash,Eliezer Masliah,Wayne C. McCormick,Susan M. McCurry,Andrew McDavid,Ann C. McKee,M.-Marsel Mesulam,Bruce L. Miller,Carol A. Miller,Joshua W. Miller,Jill R. Murrell,John M Olichney,Vernon S. Pankratz,Joseph E. Parisi,Henry L. Paulson,Elaine R. Peskind,Ronald C. Petersen,Aimee Pierce,Wayne W. Poon,Huntington Potter,Joseph F. Quinn,Ashok Raj,Murray A. Raskind,Barry Reisberg,John M. Ringman,Erik D. Roberson,Howard J. Rosen,Roger N. Rosenberg,Mary Sano,Lon S. Schneider,William W. Seeley,Amanda Smith,Joshua A. Sonnen,Salvatore Spina,Robert S. Stern,Rudolph E. Tanzi,Tricia A. Thornton-Wells,John Q. Trojanowski,Juan C. Troncoso,Otto Valladares,Vivianna M. Van Deerlin,Linda J. Van Eldik,Badri N. Vardarajan,Harry V. Vinters,Jean Paul Vonsattel,Sandra Weintraub,Kathleen A. Welsh-Bohmer,Jennifer Williamson,Sarah Wishnek,Randall L. Woltjer,Clinton B. Wright,Steven G. Younkin,Chang En Yu,Lei Yu +183 more
TL;DR: The combined effects of Alzheimer disease risk variants on AAO are on the scale of, but do not exceed, the APOE effect, and additional genetic contributions toAAO are individually likely to be small.
Journal ArticleDOI
"New Old Pathologies": AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS).
Peter T. Nelson,John Q. Trojanowski,Erin L. Abner,Omar M. Al-Janabi,Gregory A. Jicha,Frederick A. Schmitt,Charles D. Smith,David W. Fardo,Wang-Xia Wang,Richard J. Kryscio,Janna H. Neltner,Walter A. Kukull,Matthew D. Cykowski,Linda J. Van Eldik,Eseosa T. Ighodaro +14 more
TL;DR: This review provides an overview of current hypotheses about how genetic risk factors, and other pathogenetic influences contribute to TDP-43 pathology and hippocampal sclerosis and suggests a neuropathology-based diagnostic rubric for CARTS.
Journal ArticleDOI
Neurotrophic activity of S-100β in cultures of dorsal root ganglia from embryonic chick and fetal rat
Linda J. Van Eldik,Barbara Christie-Pope,Laurel M. Bolin,Eric M. Shooter,William O. Whetsell +4 more
TL;DR: S-100 beta elicited neurites from explant and dissociated cell cultures of embryonic chick DRG, and the extent of the response varied with the age of the embryo, suggesting that S-100beta may play a role in neuronal growth and/or maintenance in the peripheral nervous system.