M
Marc A. Pfeffer
Researcher at Brigham and Women's Hospital
Publications - 815
Citations - 143710
Marc A. Pfeffer is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Heart failure & Myocardial infarction. The author has an hindex of 166, co-authored 765 publications receiving 133043 citations. Previous affiliations of Marc A. Pfeffer include Partners HealthCare & University of Miami.
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Journal ArticleDOI
Mechanism of the negative inotropic action of leukotrienes C4 and D4 on isolated rat heart.
TL;DR: The results suggest that LTC4 and LTD4 are potent coronary vasoconstricting agents which depress cardiac function by limiting oxygen delivery.
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Treatment of Anemia With Darbepoetin Prior to Dialysis Initiation and Clinical Outcomes: Analyses From the Trial to Reduce Cardiovascular Events With Aranesp Therapy (TREAT)
Finnian R. Mc Causland,Brian Claggett,Emmanuel A. Burdmann,Glenn M. Chertow,Mark E. Cooper,Kai-Uwe Eckardt,Peter Ivanovich,Andrew S. Levey,Eldrin F. Lewis,Janet B. McGill,John J.V. McMurray,Patrick S. Parfrey,Hans-Henrik Parving,Giuseppe Remuzzi,Giuseppe Remuzzi,Ajay K. Singh,Scott D. Solomon,Robert D. Toto,Marc A. Pfeffer +18 more
TL;DR: Despite initiating dialysis therapy with a higher hemoglobin level, prior treatment with darbepoetin was not associated with a reduction in mortality, myocardial infarction, or heart failure in the first 180 days, but a higher frequency of stroke was observed.
Journal ArticleDOI
Inducible nitric oxide synthase and tumor necrosis factor in animal models of myocardial necrosis induced by coronary artery ligation or isoproterenol injection.
Sandrine A. Grosjean,Margaret Arstall,Richard N. Mitchell,Gunter W. Klappacher,Ralph A. Kelly,Marc A. Pfeffer,Janice M. Pfeffer +6 more
TL;DR: In this article, the expression of TNF and iNOS in the heart is increased in an experimental model of dilated cardiomyopathy that minimizes the confounding effects of surgery, supporting a role for activation of innate immunity signaling pathways in the pathogenesis of heart failure.
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Comparison of Outcomes in Patients With Diabetes Mellitus Treated With Versus Without Insulin + Heart Failure With Preserved Left Ventricular Ejection Fraction (from the TOPCAT Study).
Thao Huynh,Brian Harty,Brian Claggett,Jerome L. Fleg,Sonja M. McKinlay,Inder S. Anand,Eldrin F. Lewis,Jacob Joseph,Akshay S. Desai,Nancy K. Sweitzer,EileenO'Meara,Bertram Pitt,Marc A. Pfeffer,Jean L. Rouleau +13 more
TL;DR: In conclusion, the apparent increased risk of adverse outcomes in patients with heart failure and preserved left ventricular ejection fraction and ITDM merits future research to improve the prognosis of these high-risk patients.
Left ventricular remodeling following myocardial infarction.
TL;DR: Dipyridamole infusion determined a significant increase in heart rate and rate pressure-product in all patients (both in positive and in negative), whereas calcium induced a slight, not significant decrease of these parameters.