M
Marc A. Pfeffer
Researcher at Brigham and Women's Hospital
Publications - 815
Citations - 143710
Marc A. Pfeffer is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Heart failure & Myocardial infarction. The author has an hindex of 166, co-authored 765 publications receiving 133043 citations. Previous affiliations of Marc A. Pfeffer include Partners HealthCare & University of Miami.
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Journal ArticleDOI
Changes in vasoconstrictive hormones, natriuretic peptides, and left ventricular remodeling soon after anterior myocardial infarction.
Michel White,Jean L. Rouleau,Christian Hall,Malcolm Arnold,Francois Harel,Pierre Sirois,Sally Greaves,Scott D. Solomon,Umed A. Ajani,Robert J. Glynn,Charles H. Hennekens,Marc A. Pfeffer +11 more
TL;DR: In this article, the changes in vasoconstrictive neurohormones, N-terminal proatrial natriuretic peptide (Nt-proANP), and BNP and their relationship with left ventricular (LV) remodeling after anterior myocardial infarction (MI) were studied.
Journal ArticleDOI
Relation between renal function and response to cardiac resynchronization therapy in Multicenter Automatic Defibrillator Implantation Trial—Cardiac Resynchronization Therapy (MADIT-CRT)
Ilan Goldenberg,Arthur J. Moss,Scott McNitt,Alon Barsheshet,Daniel A. Gray,Mark L. Andrews,Mary W. Brown,Wojciech Zareba,Edward Sze,Scott D. Solomon,Marc A. Pfeffer +10 more
TL;DR: In MADIT-CRT, patients with an elevated ratio of BUN to SCr experienced a significantly greater reduction in the risk of HF or death with CRT-D therapy as compared with patients with a low ratio.
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Effect of angiotensin-converting enzyme or vasopeptidase inhibition on ventricular size and function in patients with heart failure: The Omapatrilat Versus Enalapril Randomized Trial of Utility in Reducing Events (OVERTURE) echocardiographic study
Scott D. Solomon,Hicham Skali,Mikhail Bourgoun,James C. Fang,Jalal K. Ghali,Michel Martelet,Dariusz Wojciechowski,Baiba Ansmite,Janis Skards,Toivo Laks,David Henry,Milton Packer,Marc A. Pfeffer +12 more
TL;DR: Ventricular size and function improved similarly after 1 year with ACE or vasopeptidase inhibition in patients with heart failure and reverse remodeling was associated with improved outcome.
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Influence of Hospitalization for Cardiovascular Versus Noncardiovascular Reasons on Subsequent Mortality in Patients With Chronic Heart Failure Across the Spectrum of Ejection Fraction
Akshay S. Desai,Brian Claggett,Marc A. Pfeffer,Natalie A. Bello,Peter V. Finn,Christopher B. Granger,John J.V. McMurray,Stuart J. Pocock,Karl Swedberg,Salim Yusuf,Scott D. Solomon +10 more
TL;DR: Non-CV hospitalization is frequent in patients with symptomatic heart failure and associated with risk of subsequent mortality similar to CV hospitalization across the spectrum of EF, which may have implications for developing strategies to prevent readmissions.
Journal ArticleDOI
Association of Natriuretic Peptides With Cardiovascular Prognosis in Heart Failure With Preserved Ejection Fraction: Secondary Analysis of the TOPCAT Randomized Clinical Trial.
Peder L. Myhre,Peder L. Myhre,Muthiah Vaduganathan,Brian Claggett,Inder S. Anand,Inder S. Anand,Nancy K. Sweitzer,James C. Fang,Eileen O'Meara,Sanjiv J. Shah,Akshay S. Desai,Eldrin F. Lewis,Jean L. Rouleau,Bertram Pitt,Marc A. Pfeffer,Scott D. Solomon +15 more
TL;DR: Elevated NP levels (per 1-SD increase) were independently associated with an increased risk of the primary outcome and a single, absolute NP threshold for inclusion in contemporary HFpEF trials may lead to an underrepresentation of certain demographic and clinical subgroups.