Marc A. Pfeffer

TL;DR: Discussion by Dr Pfeffer on the conduct of these trials to be relevant to trials of other therapies in nephrology, such as those for phosphorus binding agents, for example the DCOR (Dialysis Clinical Outcomes Revisited) study presented elsewhere in this issue of AJKD.

TL;DR: Despite substantial LV reverse remodeling with CRT, interruption of long-term CRT after 12 months resulted in an acute worsening of LV size and function, LA volumes, and right ventricular function, with concomitant worsening of ventricular synchrony despite minimal change to the observed improvement in LV strain measures of contractile function.

TL;DR: In this article, the authors identify barriers to successful hospitalized heart failure clinical trial participation in the USA and suggest possible solutions, including a lack of incentive for investigators and institutions, the relative value unit-based compensation system, poor institutional framework for identification of appropriate patients, and increasing liability to conduct trials.

TL;DR: In patients with type 2 diabetes, CKD and anemia, PP did not independently predict cardiovascular events or ESRD, and may reflect confounding by aggressive antihypertensive treatment, or PP may be too rough a risk marker in these high-risk patients.

TL;DR: In this paper, the authors measured pulsatile hemodynamics and proximal aortic diameter directly using tonometry, ultrasound imaging, and Doppler in 167 individuals with systolic hypertension.