Marc A. Pfeffer

TL;DR: Prelischarge ECG may be a useful tool for early identification of patients at risk of ventricular enlargement and persistent dysfunction following myocardial infarction, and the sum of ST- and maximum ST-segment elevation and the number of leads with ST-Segment elevation > or =1 mm in the predischarge ECGs were independent predictors of vent cardiac enlargement.

TL;DR: This review focuses on the arguments for conducting posttrial database studies and presents examples of studies in which posttrial knowledge generation has been substantial, and the potential for post trial database studies to become a platform for training young scientists is outlined.

TL;DR: Several completed or ongoing trials illustrate the feasibility of using registry-based controlled trials to answer important questions relevant to daily clinical practice and how trials might be simplified while maintaining randomisation to preserve scientific integrity and unbiased efficacy assessments.

TL;DR: Three questions from the MNSI are identified that provide additional prognostic information for individuals with type 2 diabetes and CKD and/or CVD and if externally validated, these questions may be integrated into the clinical history to augment prediction of CV events in high-risk individuals withtype 2 diabetes.

TL;DR: Sacubitril/valsartan attenuates the deterioration of renal function to a greater extent in patients with diabetes and HF with reduced ejection fraction compared with renin–angiotensin system inhibitors alone.