M
Marc A. Pfeffer
Researcher at Brigham and Women's Hospital
Publications - 815
Citations - 143710
Marc A. Pfeffer is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Heart failure & Myocardial infarction. The author has an hindex of 166, co-authored 765 publications receiving 133043 citations. Previous affiliations of Marc A. Pfeffer include Partners HealthCare & University of Miami.
Papers
More filters
Journal ArticleDOI
Contemporary management of patients with left ventricular systolic dysfunction. Results from the Study of Patients Intolerant of Converting Enzyme Inhibitors (SPICE) Registry
Bradley A. Bart,Bradley A. Bart,George Ertl,P. Held,J. Kuch,Aldo P. Maggioni,Jjv McMurray,Eric L. Michelson,Jean-Lucien Rouleau,L. Warner Stevenson,Karl Swedberg,James B. Young,Salim Yusuf,Mary Ann Sellers,Christopher B. Granger,Robert M. Califf,Marc A. Pfeffer +16 more
TL;DR: The SPICE Registry provides a contemporary description of the demographics and management of patients with documented left ventricular systolic dysfunction and the contemporary use of ACE inhibitors appears to be higher than previously reported and the main reason for non-use is perceived intolerance.
Journal ArticleDOI
Mortality and morbidity remain high despite captopril and/or valsartan therapy in elderly patients with left ventricular systolic dysfunction, heart failure, or both after acute myocardial infarction - Results from the Valsartan in Acute Myocardial Infarction Trial (VALIANT)
Harvey D. White,Philip E. Aylward,Zhen Huang,Anthony J. Dalby,W. Douglas Weaver,Ståle Barvik,José Antonio Marin-Neto,Jan Murin,Rolf Nordlander,Wiek H. van Gilst,Faiez Zannad,John J.V. McMurray,Robert M. Califf,Marc A. Pfeffer +13 more
TL;DR: Outcomes remained poor in elderly patients with heart failure and/ or impaired left ventricular systolic function after acute myocardial infarction, although most received &bgr;-blockers and all received an ACE inhibitor and/or an angiotensin receptor blocker.
Journal ArticleDOI
Activation of neurohumoral systems following acute myocardial infarction
Jean L. Rouleau,Lemuel A. Moyé,Jacques de Champlain,Marc Klein,Daniel G. Bichet,Milton Packer,Bruce Sussex,J. Malcolm O. Arnold,Francois Sestier,John O. Parker,M.M.Patricia McEwan,Victoria Bernstein,Thomas E. Cuddy,François Delage,Claude Nadeau,Gervasio A. Lamas,Stephen S. Gottlieb,John McCans,Marc A. Pfeffer +18 more
TL;DR: The results indicate that, in fact, a subgroup of patients without overt heart failure has persistent neurohumoral activation at the time of hospital discharge postinfarction, and that this activation involves several neurohumological systems.
Journal ArticleDOI
Gastrointestinal bleeding in high risk survivors of myocardial infarction: the VALIANT Trial
George V. Moukarbel,James Signorovitch,Marc A. Pfeffer,John J.V. McMurray,Harvey D. White,Aldo P. Maggioni,Eric J. Velazquez,Robert M. Califf,James M. Scheiman,Scott D. Solomon +9 more
TL;DR: Following MI, clinical characteristics can identify patients with increased risk of GI bleeding, and the use of dual antiplatelet agents appears to be the most profound risk factor.
Journal ArticleDOI
Mechanical dyssynchrony after myocardial infarction in patients with left ventricular dysfunction, heart failure, or both.
Sung Hee Shin,Chung-Lieh Hung,Hajime Uno,Amira H Hassanein,Anil Verma,Mikhail Bourgoun,Lars Køber,Jalal K. Ghali,Eric J. Velazquez,Robert M. Califf,Marc A. Pfeffer,Scott D. Solomon +11 more
TL;DR: Left ventricular dyssynchrony is independently associated with increased risk of death or heart failure after myocardial infarction, suggesting that contractile pattern may play a role in post–myocardial Infarction prognosis.