M
Megha Padi
Researcher at University of Arizona
Publications - 34
Citations - 1191
Megha Padi is an academic researcher from University of Arizona. The author has contributed to research in topics: Gene regulatory network & Gene. The author has an hindex of 13, co-authored 29 publications receiving 914 citations. Previous affiliations of Megha Padi include Harvard University.
Papers
More filters
Journal ArticleDOI
Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins
Orit Rozenblatt-Rosen,Rahul C. Deo,Rahul C. Deo,Megha Padi,Guillaume Adelmant,Michael A. Calderwood,Thomas Rolland,Miranda Grace,Miranda Grace,Amélie Dricot,Manor Askenazi,Maria Tavares,Sam Pevzner,Sam Pevzner,Fieda Abderazzaq,Danielle Byrdsong,Anne-Ruxandra Carvunis,Alyce A. Chen,Alyce A. Chen,Jingwei Cheng,Jingwei Cheng,Mick Correll,Melissa Duarte,Melissa Duarte,Changyu Fan,Mariet C.W. Feltkamp,Scott B. Ficarro,Rachel Franchi,Rachel Franchi,Brijesh K. Garg,Natali Gulbahce,Tong Hao,Amy M. Holthaus,Amy M. Holthaus,Robert James,Anna Korkhin,Anna Korkhin,Larisa Litovchick,Larisa Litovchick,Jessica C. Mar,Theodore R. Pak,Sabrina Rabello,Renee Rubio,Yun Shen,Saurav Singh,Jennifer M. Spangle,Jennifer M. Spangle,Murat Tasan,Murat Tasan,Shelly Wanamaker,Shelly Wanamaker,James T. Webber,Jennifer Roecklein-Canfield,Jennifer Roecklein-Canfield,Eric Johannsen,Eric Johannsen,Albert-László Barabási,Rameen Beroukhim,Rameen Beroukhim,Rameen Beroukhim,Elliott Kieff,Elliott Kieff,Michael E. Cusick,David E. Hill,Karl Münger,Karl Münger,Jarrod A. Marto,John Quackenbush,Frederick P. Roth,James A. DeCaprio,James A. DeCaprio,Marc Vidal +71 more
TL;DR: It is shown that systematic analyses of host targets of viral proteins can identify cancer genes with a success rate on a par with their identification through functional genomics and large-scale cataloguing of tumour mutations, to increase the specificity of cancer gene identification.
Journal ArticleDOI
Integration of TP53, DREAM, MMB-FOXM1 and RB-E2F target gene analyses identifies cell cycle gene regulatory networks
TL;DR: The approach yields high confidence ranked target gene maps for TP53, DREAM, MMB-FOXM1 and RB-E2F and enables prediction and distinction of CC regulation.
Journal ArticleDOI
Viral Perturbations of Host Networks Reflect Disease Etiology
Natali Gulbahce,Han Yan,Amélie Dricot,Megha Padi,Danielle Byrdsong,Rachel Franchi,Deok-Sun Lee,Deok-Sun Lee,Orit Rozenblatt-Rosen,Jessica C. Mar,Michael A. Calderwood,Amy Baldwin,Amy Baldwin,Bo Zhao,Balaji Santhanam,Pascal Braun,Nicolas Simonis,Nicolas Simonis,Kyung-Won Huh,Kyung-Won Huh,Karin Hellner,Miranda Grace,Alyce A. Chen,Renee Rubio,Jarrod A. Marto,Nicholas A. Christakis,Elliott Kieff,Frederick P. Roth,Jennifer Roecklein-Canfield,Jennifer Roecklein-Canfield,James A. DeCaprio,Michael E. Cusick,John Quackenbush,David E. Hill,Karl Münger,Marc Vidal,Albert-László Barabási,Albert-László Barabási +37 more
TL;DR: In this article, the authors examined whether viral perturbations of host interactome may underlie such virally implicated disease relationships, using as models two different human viruses, Epstein-Barr virus (EBV) and human papillomavirus (HPV).
Journal ArticleDOI
Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis
Jingwei Cheng,Donglim Esther Park,Christian Berrios,Elizabeth A. White,Reety Arora,Rosa Yoon,Timothy Branigan,Tengfei Xiao,Thomas Westerling,Thomas Westerling,Alexander J. Federation,Rhamy Zeid,Benjamin J. Strober,Selene K. Swanson,Laurence Florens,James E. Bradner,James E. Bradner,Myles Brown,Peter M. Howley,Megha Padi,Michael P. Washburn,Michael P. Washburn,James A. DeCaprio,James A. DeCaprio +23 more
TL;DR: It is demonstrated that ST can activate gene expression in a EP400 and MYCL dependent manner and this activity contributes to cellular transformation and generation of induced pluripotent stem cells.
Journal ArticleDOI
Effects of ursodeoxycholic acid on the gut microbiome and colorectal adenoma development.
Talima Pearson,J. Gregory Caporaso,Monica Yellowhair,Nicholas A. Bokulich,Megha Padi,Denise J. Roe,Betsy C. Wertheim,Mark Linhart,Jessica A. Martinez,Cherae Bilagody,Heidie Hornstra,David S. Alberts,Peter Lance,Patricia A. Thompson,Patricia A. Thompson +14 more
TL;DR: Daily UDCA use modestly influences the relative abundance of microbial species in stool and affects the microbial network composition with suggestive evidence for sex‐specific effects of UDCA on stool microbial community composition as a modifier of colorectal adenoma risk.