M
Michael Soyka
Researcher at Ludwig Maximilian University of Munich
Publications - 435
Citations - 13915
Michael Soyka is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Alcohol dependence & Poison control. The author has an hindex of 57, co-authored 411 publications receiving 12577 citations. Previous affiliations of Michael Soyka include National Institute on Drug Abuse & University of Regensburg.
Papers
More filters
Reference EntryDOI
Opioid antagonists for alcohol dependence
Susanne Rösner,Andrea Hackl-Herrwerth,Stefan Leucht,Simona Vecchi,Manit Srisurapanont,Michael Soyka +5 more
TL;DR: Findings support that short-term treatment of NTX decreases the chance of alcohol relapses for 36% (number-needed-to-treat or NNT = 7) and likely to reduce the chances of returning to drinking for 13% (NNT = 12), and NTX treatment can lower the risk of treatment withdrawal in alcohol-dependent patients for 28% (NTT = 13).
Journal ArticleDOI
The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption.
Rainer Spanagel,Gurudutt Pendyala,Carolina Abarca,Tarek Zghoul,Carles Sanchis-Segura,Maria Chiara Magnone,Jesús Lascorz,Martin Depner,David Holzberg,Michael Soyka,Stefan Schreiber,Fumihiko Matsuda,G. Mark Lathrop,Gunter Schumann,Urs Albrecht,Urs Albrecht +15 more
TL;DR: In this article, the glutamate levels increase in the extracellular space of Per2Brdm1 mutant mice, which have a deletion in the PAS domain of the Per2 protein, leading to reduced uptake of glutamate by astrocytes.
Journal ArticleDOI
Relapse prevention by acamprosate. Results from a placebo-controlled study on alcohol dependence
TL;DR: Acamprosate proved to be a safe and effective aid in treating alcohol-dependent patients and in maintaining the abstinence of patients during 2 years.
Journal ArticleDOI
A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis
Stephan Buch,Felix Stickel,Eric Trepo,Michael J. Way,A Herrmann,Hans Dieter Nischalke,Mario Brosch,Jonas Rosendahl,Thomas Berg,Monika Ridinger,Marcella Rietschel,Andrew McQuillin,Josef Frank,Falk Kiefer,Stefan Schreiber,Wolfgang Lieb,Michael Soyka,Nasser Semmo,Elmar Aigner,Christian Datz,Renate Schmelz,Stefan Brückner,Sebastian Zeissig,Anna-Magdalena Stephan,Norbert Wodarz,Jacques Devière,Nicolas Clumeck,Christoph Sarrazin,Frank Lammert,Thierry Gustot,Pierre Deltenre,Pierre Deltenre,Henry Völzke,Markus M. Lerch,Julia Mayerle,Florian Eyer,Clemens Schafmayer,Sven Cichon,Markus M. Nöthen,Michael Nothnagel,David Ellinghaus,Klaus Huse,Andre Franke,Steffen Zopf,Claus Hellerbrand,Christophe Moreno,Denis Franchimont,Marsha Y. Morgan,Jochen Hampe +48 more
TL;DR: A genome-wide association study for alcohol-related cirrhosis in individuals of European descent with subsequent validation in two independent European cohorts is performed, suggesting that lipid turnover is important in the pathogenesis of alcohol- related Cirrhosis.
Journal ArticleDOI
Genome-wide association study of alcohol dependence.
Jens Treutlein,Sven Cichon,Monika Ridinger,Norbert Wodarz,Michael Soyka,Peter Zill,Wolfgang Maier,Rainald Moessner,Wolfgang Gaebel,Norbert Dahmen,Christoph Fehr,Norbert Scherbaum,Michael Steffens,Kerstin U. Ludwig,Josef Frank,H.-Erich Wichmann,Stefan Schreiber,Nico Dragano,Wolfgang H. Sommer,Fernando Leonardi-Essmann,Anbarasu Lourdusamy,Peter J. Gebicke-Haerter,Thomas F. Wienker,Patrick F. Sullivan,Markus M. Nöthen,Falk Kiefer,Rainer Spanagel,Karl Mann,Marcella Rietschel +28 more
TL;DR: This is the first GWAS and follow-up study to identify a genome-wide significant association in alcohol dependence and nine SNPs were located in genes that have been reported to be associated with alcohol dependence, including the CDH13 and ADH1C genes.