Minoru Isomura

TL;DR: A meta-analysis of associations between BMI and ∼2.5 million genotyped or imputed single nucleotide polymorphisms among 86 757 individuals of Asian ancestry, followed by in silico and de novo replication among 7488-47 352 additional Asian-ancestry individuals finds the association of BMI with rs2237892, rs671 and rs12229654 was significantly stronger among men than among women.

TL;DR: The data suggest that MLH1 hemizygous deletion, through increasing the rate of indel mutations, could drive the development and progression of sporadic cancers.

TL;DR: Plasma MSTN level was elevated in an early stage of CKD, which could be involved in the progression of sarcopenia.

TL;DR: The stroke-prone spontaneously hypertensive rat (SHRSP) is a unique genetic model of severe hypertension and cerebral stroke and genetic studies in SHRSP and other rat models must be focused on the pathogenetic roles of ‘networks of interacting genes’ in hypertension.

TL;DR: In Asians, the possibility that positive selection accentuated genetic differentiation among distant populations but attenuated genetic differentiate among close populations is found, which is significant for studies of human evolution and medical genetics.