Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index
Wanqing Wen,Wei Zheng,Yukinori Okada,Fumihiko Takeuchi,Yasuharu Tabara,Joo-Yeon Hwang,Rajkumar Dorajoo,Huaixing Li,Fuu Jen Tsai,Xiaobo Yang,Jiang He,Ying Wu,Meian He,Yi Zhang,Jun Liang,Xiuqing Guo,Wayne Huey-Herng Sheu,Ryan J. Delahanty,Xingyi Guo,Michiaki Kubo,Ken Yamamoto,Takayoshi Ohkubo,Min Jin Go,Jianjun Liu,Wei Gan,Ching-Chu Chen,Yong Gao,Shengxu Li,Nanette R. Lee,Chen Wu,Xueya Zhou,Huai-Dong Song,Jie Yao,I-Te Lee,Jirong Long,Tatsuhiko Tsunoda,Koichi Akiyama,Naoyuki Takashima,Yoon Shin Cho,Rick Th Ong,Ling Lu,Chien-Hsiun Chen,Aihua Tan,Treva Rice,Linda S. Adair,Lixuan Gui,Matthew A. Allison,Wen-Jane Lee,Qiuyin Cai,Minoru Isomura,Satoshi Umemura,Young-Jin Kim,Mark Seielstad,James E. Hixson,Yong-Bing Xiang,Masato Isono,Bong-Jo Kim,Xueling Sim,Wei Lu,Toru Nabika,Juyoung Lee,Wei-Yen Lim,Yu-Tang Gao,Ryoichi Takayanagi,Daehee Kang,Tien Yin Wong,Chao A. Hsiung,I-Chien Wu,Jyh-Ming Jimmy Juang,Jiajun Shi,Bo Youl Choi,Tin Aung,Frank B. Hu,Mi Kyung Kim,Wei-Yen Lim,Tzung-Dao Wang,Min-Ho Shin,Jeannette Lee,Bu-Tian Ji,Young-Hoon Lee,Terri L. Young,Dong Hoon Shin,Byung-Yeol Chun,Myeong Chan Cho,Bok-Ghee Han,Chii-Min Hwu,Themistocles L. Assimes,Devin Absher,Xiaofei Yan,Eric Kim,Jane Z. Kuo,Soonil Kwon,Kent D. Taylor,Yii-Der Ida Chen,Jerome I. Rotter,Lu Qi,Dingliang Zhu,Tangchun Wu,Karen L. Mohlke,Dongfeng Gu,Zengnan Mo,Jer-Yuarn Wu,Xu Lin,Tetsuro Miki,E. Shyong Tai,Jong-Young Lee,Norihiro Kato,Xiao-Ou Shu,Toshihiro Tanaka +108 more
TLDR
A meta-analysis of associations between BMI and ∼2.5 million genotyped or imputed single nucleotide polymorphisms among 86 757 individuals of Asian ancestry, followed by in silico and de novo replication among 7488-47 352 additional Asian-ancestry individuals finds the association of BMI with rs2237892, rs671 and rs12229654 was significantly stronger among men than among women.Abstract:
Recent genetic association studies have identified 55 genetic loci associated with obesity or body mass index (BMI). The vast majority, 51 loci, however, were identified in European-ancestry populations. We conducted a meta-analysis of associations between BMI and ∼2.5 million genotyped or imputed single nucleotide polymorphisms among 86 757 individuals of Asian ancestry, followed by in silico and de novo replication among 7488-47 352 additional Asian-ancestry individuals. We identified four novel BMI-associated loci near the KCNQ1 (rs2237892, P = 9.29 × 10(-13)), ALDH2/MYL2 (rs671, P = 3.40 × 10(-11); rs12229654, P = 4.56 × 10(-9)), ITIH4 (rs2535633, P = 1.77 × 10(-10)) and NT5C2 (rs11191580, P = 3.83 × 10(-8)) genes. The association of BMI with rs2237892, rs671 and rs12229654 was significantly stronger among men than among women. Of the 51 BMI-associated loci initially identified in European-ancestry populations, we confirmed eight loci at the genome-wide significance level (P < 5.0 × 10(-8)) and an additional 14 at P < 1.0 × 10(-3) with the same direction of effect as reported previously. Findings from this analysis expand our knowledge of the genetic basis of obesity.read more
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Integrative approaches for large-scale transcriptome-wide association studies.
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TL;DR: A powerful strategy that integrates gene expression measurements with summary association statistics from large-scale genome-wide association studies (GWAS) to identify genes whose cis-regulated expression is associated with complex traits is introduced.
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Genome-wide association study identifies 112 new loci for body mass index in the Japanese population
Masato Akiyama,Yukinori Okada,Masahiro Kanai,Atsushi Takahashi,Yukihide Momozawa,Masashi Ikeda,Nakao Iwata,Shiro Ikegawa,Makoto Hirata,Koichi Matsuda,Motoki Iwasaki,Taiki Yamaji,Norie Sawada,Tsuyoshi Hachiya,Kozo Tanno,Atsushi Shimizu,Atsushi Hozawa,Naoko Minegishi,Shoichiro Tsugane,Masayuki Yamamoto,Michiaki Kubo,Yoichiro Kamatani +21 more
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Genetics of obesity: what genetic association studies have taught us about the biology of obesity and its complications
TL;DR: Gene by environment and lifestyle interaction analyses have revealed that the authors' increasingly obesogenic environment might be amplifying genetic risk for obesity, yet those at highest risk could mitigate this risk by increasing physical activity and possibly by avoiding specific dietary components.
Journal ArticleDOI
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
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Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
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