L
Lixuan Gui
Researcher at Huazhong University of Science and Technology
Publications - 14
Citations - 745
Lixuan Gui is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Genome-wide association study & Odds ratio. The author has an hindex of 10, co-authored 11 publications receiving 590 citations. Previous affiliations of Lixuan Gui include Cedars-Sinai Medical Center.
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Journal ArticleDOI
Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index
Wanqing Wen,Wei Zheng,Yukinori Okada,Fumihiko Takeuchi,Yasuharu Tabara,Joo-Yeon Hwang,Rajkumar Dorajoo,Huaixing Li,Fuu Jen Tsai,Xiaobo Yang,Jiang He,Ying Wu,Meian He,Yi Zhang,Jun Liang,Xiuqing Guo,Wayne Huey-Herng Sheu,Ryan J. Delahanty,Xingyi Guo,Michiaki Kubo,Ken Yamamoto,Takayoshi Ohkubo,Min Jin Go,Jianjun Liu,Wei Gan,Ching-Chu Chen,Yong Gao,Shengxu Li,Nanette R. Lee,Chen Wu,Xueya Zhou,Huai-Dong Song,Jie Yao,I-Te Lee,Jirong Long,Tatsuhiko Tsunoda,Koichi Akiyama,Naoyuki Takashima,Yoon Shin Cho,Rick Th Ong,Ling Lu,Chien-Hsiun Chen,Aihua Tan,Treva Rice,Linda S. Adair,Lixuan Gui,Matthew A. Allison,Wen-Jane Lee,Qiuyin Cai,Minoru Isomura,Satoshi Umemura,Young-Jin Kim,Mark Seielstad,James E. Hixson,Yong-Bing Xiang,Masato Isono,Bong-Jo Kim,Xueling Sim,Wei Lu,Toru Nabika,Juyoung Lee,Wei-Yen Lim,Yu-Tang Gao,Ryoichi Takayanagi,Daehee Kang,Tien Yin Wong,Chao A. Hsiung,I-Chien Wu,Jyh-Ming Jimmy Juang,Jiajun Shi,Bo Youl Choi,Tin Aung,Frank B. Hu,Mi Kyung Kim,Wei-Yen Lim,Tzung-Dao Wang,Min-Ho Shin,Jeannette Lee,Bu-Tian Ji,Young-Hoon Lee,Terri L. Young,Dong Hoon Shin,Byung-Yeol Chun,Myeong Chan Cho,Bok-Ghee Han,Chii-Min Hwu,Themistocles L. Assimes,Devin Absher,Xiaofei Yan,Eric Kim,Jane Z. Kuo,Soonil Kwon,Kent D. Taylor,Yii-Der Ida Chen,Jerome I. Rotter,Lu Qi,Dingliang Zhu,Tangchun Wu,Karen L. Mohlke,Dongfeng Gu,Zengnan Mo,Jer-Yuarn Wu,Xu Lin,Tetsuro Miki,E. Shyong Tai,Jong-Young Lee,Norihiro Kato,Xiao-Ou Shu,Toshihiro Tanaka +108 more
TL;DR: A meta-analysis of associations between BMI and ∼2.5 million genotyped or imputed single nucleotide polymorphisms among 86 757 individuals of Asian ancestry, followed by in silico and de novo replication among 7488-47 352 additional Asian-ancestry individuals finds the association of BMI with rs2237892, rs671 and rs12229654 was significantly stronger among men than among women.
Journal ArticleDOI
Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.
Cassandra N. Spracklen,Peng Chen,Peng Chen,Young-Jin Kim,Xu Wang,Hui Cai,Shengxu Li,Jirong Long,Ying Wu,Ya Xing Wang,Fumihiko Takeuchi,Jer-Yuarn Wu,Jer-Yuarn Wu,Keum Ji Jung,Cheng Hu,Koichi Akiyama,Yonghong Zhang,Sanghoon Moon,Todd A. Johnson,Huaixing Li,Rajkumar Dorajoo,Meian He,Maren E Cannon,Tamara S. Roman,Elias Salfati,Keng-Hung Lin,Xiuqing Guo,Wayne Huey-Herng Sheu,Devin Absher,Linda S. Adair,Themistocles L. Assimes,Tin Aung,Qiuyin Cai,Li-Ching Chang,Chien-Hsiun Chen,Chien-Hsiun Chen,Li-Hsin Chien,Lee-Ming Chuang,Shu-Chun Chuang,Shufa Du,Qiao Fan,Cathy S.J. Fann,Alan B. Feranil,Yechiel Friedlander,Penny Gordon-Larsen,Dongfeng Gu,Lixuan Gui,Zhirong Guo,Chew-Kiat Heng,Chew-Kiat Heng,James E. Hixson,Xuhong Hou,Chao A. Hsiung,Yao Hu,Mi Yeong Hwang,Chii-Min Hwu,Chii-Min Hwu,Masato Isono,Jyh-Ming Jimmy Juang,Chiea Chuen Khor,Chiea Chuen Khor,Yun Kyoung Kim,Woon-Puay Koh,Michiaki Kubo,I-Te Lee,I-Te Lee,Sun-Ju Lee,Wen-Jane Lee,Kae-Woei Liang,Kae-Woei Liang,Blanche Lim,Sing-Hui Lim,Jianjun Liu,Jianjun Liu,Toru Nabika,Wen-Harn Pan,Hao Peng,Thomas Quertermous,Charumathi Sabanayagam,Kevin Sandow,Shi Jinxiu,Liang Sun,Pok Chien Tan,Shu-Pei Tan,Kent D. Taylor,Yik Ying Teo,Sue-Anne Toh,Tatsuhiko Tsunoda,Rob M. van Dam,Aili Wang,Feijie Wang,Jie Wang,Wen Bin Wei,Yong-Bing Xiang,Jie Yao,Jian-Min Yuan,Rong Zhang,Wanting Zhao,Yii-Der Ida Chen,Stephen S. Rich,Jerome I. Rotter,Tzung-Dau Wang,Tangchun Wu,Xu Lin,Bok-Ghee Han,Toshihiro Tanaka,Yoon Shin Cho,Tomohiro Katsuya,Weiping Jia,Sun Ha Jee,Yuan-Tsong Chen,Norihiro Kato,Jost B. Jonas,Jost B. Jonas,Ching-Yu Cheng,Xiao-Ou Shu,Jiang He,Wei Zheng,Tien Yin Wong,Wei Huang,Bong-Jo Kim,E-Shyong Tai,Karen L. Mohlke,Xueling Sim +123 more
TL;DR: Two meta‐analyses combined results from the East Asian meta‐analysis with association results from up to 187,365 European individuals from the Global Lipids Genetics Consortium in a trans‐ancestry meta‐ analysis identified multiple novel lipid loci, providing new potential therapeutic targets.
Journal ArticleDOI
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci
Meian He,Min Xu,Ben Zhang,Jun Liang,Peng Chen,Jong-Young Lee,Todd A. Johnson,Huaixing Li,Xiaobo Yang,Juncheng Dai,Liming Liang,Lixuan Gui,Qibin Qi,Jinyan Huang,Yanping Li,Linda S. Adair,Tin Aung,Qiuyin Cai,Ching-Yu Cheng,Ching-Yu Cheng,Myeong Chan Cho,Yoon Shin Cho,Minjie Chu,Bin Cui,Yu-Tang Gao,Min Jin Go,Dongfeng Gu,Weiqiong Gu,Huan Guo,Yongchen Hao,Jie Hong,Zhibin Hu,Yanling Hu,Jianfeng Huang,Joo Yeon Hwang,Mohammad Kamran Ikram,Mohammad Kamran Ikram,Mohammad Kamran Ikram,Guangfu Jin,Daehee Kang,Chiea Chuen Khor,Bong Jo Kim,Hung Tae Kim,Michiaki Kubo,Jeannette Lee,Juyoung Lee,Nanette R. Lee,Ruoying Li,Jun Li,Jianjun Liu,Jirong Longe,Wei Lu,Xiangfeng Lu,Xiaoping Miao,Yukinori Okada,Rick Twee-Hee Ong,Gaokun Qiu,Mark Seielstad,Xueling Sim,Huai-Dong Song,Fumihiko Takeuchi,Toshihiro Tanaka,Phil R. Taylor,Laiyuan Wang,Weiqing Wang,Yiqin Wang,Chen Wu,Ying Wu,Yong-Bing Xiang,Ken Yamamoto,Handong Yang,Ming Liao,Mitsuhiro Yokota,Terri L. Young,Xiaomin Zhang,Norihiro Kato,Qing Kenneth Wang,Wei Zheng,Frank B. Hu,Dongxin Lin,Hongbing Shen,Yik Ying Teo,Zengnan Mo,Tien Yin Wong,Tien Yin Wong,Xu Lin,Karen L. Mohlke,Guang Ning,Tatsuhiko Tsunoda,Bok Ghee Han,Xiao-Ou Shu,E. Shyong Tai,Tangchun Wu,Lu Qi +93 more
TL;DR: 98 loci are identified, including 17 novel and 81 previously reported loci, associated with height at P < 5 × 10(-8), together explaining 8.89% of phenotypic variance, and novel biological pathway such as the protein tyrosine phosphatase family is involved in regulation of height.
Journal ArticleDOI
Association between serum uric acid and the metabolic syndrome among a middle- and old-age Chinese population.
Xiayun Dai,Jing Yuan,Ping Yao,Binyao Yang,Lixuan Gui,Xiaomin Zhang,Huan Guo,Youjie Wang,Weihong Chen,Sheng Wei,Xiaoping Miao,Xiulou Li,Xinwen Min,Handong Yang,Weimin Fang,Yuan Liang,Frank B. Hu,Tangchun Wu,Meian He +18 more
TL;DR: Among a middle- and old-age Chinese population, serum uric acid concentrations were strongly associated with the risk of MetS and its several components and whether this association was causal remained to be investigated in the future studies.
Journal ArticleDOI
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk
Meian He,Meian He,Chen Wu,Jianfeng Xu,Huan Guo,Handong Yang,Xiaomin Zhang,Xiaomin Zhang,Jielin Sun,Dianke Yu,Li Zhou,Tao Peng,Yunfeng He,Yong Gao,Yong Gao,Jing Yuan,Qifei Deng,Xiayun Dai,Aihua Tan,Yingying Feng,Haiying Zhang,Xinwen Min,Xiaobo Yang,Jiang Zhu,Kan Zhai,Jiang Chang,Xue Qin,Wen Tan,Yanling Hu,Mingjian Lang,Sha Tao,Yuanfeng Li,Yi Li,Junjie Feng,Dongfeng Li,Seong Tae Kim,Shijun Zhang,Hongxing Zhang,S. Lilly Zheng,Lixuan Gui,Youjie Wang,Sheng Wei,Feng Wang,Weimin Fang,Yuan Liang,Yun Zhai,Weihong Chen,Xiaoping Miao,Gangqiao Zhou,Frank B. Hu,Dongxin Lin,Zengnan Mo,Tangchun Wu +52 more
TL;DR: The ABO variants were associated withrisk of OSCC and pancreatic cancers and AFP variants with risk of hepatocellular cancer and several loci associated with CA19-9, CEA and AFP concentrations were identified.