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Nicholas A. Peppas
Researcher at University of Texas at Austin
Publications - 840
Citations - 101193
Nicholas A. Peppas is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: Self-healing hydrogels & Polymer. The author has an hindex of 141, co-authored 825 publications receiving 90533 citations. Previous affiliations of Nicholas A. Peppas include National Technical University & University of Texas System.
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Chronobiology, drug delivery, and chronotherapeutics.
TL;DR: Next generation drug-delivery systems must be configurable so they respond to sensitive biomarkers of disease activity that often vary in time as periodic (circadian rhythmic) and non-periodic patterns to release medication to targeted tissue(s) on a real time as needed basis, and are cost-effective.
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Therapeutic applications of hydrogels in oral drug delivery.
TL;DR: Hydrogels are excellent candidates for oral drug delivery, due to the number of adaptable parameters that enable controlled delivery of diverse therapeutic molecules, but further work is required to more accurately simulate physiological conditions and enhance performance, which is important to achieve improved bioavailability and increase commercial interest.
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Ultrapure poly(vinyl alcohol) hydrogels with mucoadhesive drug delivery characteristics
TL;DR: In this article, 15 or 20% aqueous polyvinyl alcohol (PVA) hydrogels were prepared using repeated cycles of freezing for 6 or 12 hours at − 20 °C and thawing for 2 hours at 25 °C.
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Dissolution mechanism of semicrystalline poly(vinyl alcohol) in water
TL;DR: In this article, changes occurring in the degree of crystallinity and lamellar thickness distribution of polyvinyl alcohol (PVA) samples during dissolution in water were investigated, and a dissolution mechanism involving unfolding of the polymer chains of the crystal was proposed.
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Current state and challenges in developing oral vaccines.
TL;DR: The rationale for oral vaccines is addressed, including key biological and physicochemical considerations for next-generation oral vaccine design.