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Nicholas A. Peppas
Researcher at University of Texas at Austin
Publications - 840
Citations - 101193
Nicholas A. Peppas is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: Self-healing hydrogels & Polymer. The author has an hindex of 141, co-authored 825 publications receiving 90533 citations. Previous affiliations of Nicholas A. Peppas include National Technical University & University of Texas System.
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Molecular calculations of poly(ethylene glycol) transport across a swollen poly(acrylic acid)/mucin interface.
TL;DR: The transport of poly(ethylene glycol) chains than can promote mucoadhesion across the interface between lightly cross-linked poly(acrylic acid) and mucin may be analyzed as a function of molecular characteristics using theories of chain penetration in a dilute network.
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110th Anniversary: Nanoparticle mediated drug delivery for the treatment of Alzheimer's disease: Crossing the blood-brain barrier.
TL;DR: N nanoparticles are generally low-cost technologies, which can be used for non-invasive administrations, and formulations are highly tunable to increase drug loading, targeting, and release efficacy, thus improving the bioavailability, pharmacokinetics, and pharmacodynamics of therapeutic agents.
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Combination Strategy with Complexation Hydrogels and Cell-Penetrating Peptides for Oral Delivery of Insulin
Yu Fukuoka,El-Sayed Khafagy,El-Sayed Khafagy,Takahiro Goto,Noriyasu Kamei,Kozo Takayama,Nicholas A. Peppas,Mariko Takeda-Morishita +7 more
TL;DR: The results indicate that the combination of P(MAA-g-EG) hydrogels with CPPs may be a promising strategy for the oral delivery of various insulin preparations as an alternative to conventional parenteral routes.
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Temperature- and pH- Sensitive Hydrogels for Controlled Release of Antithrombotic Agents
TL;DR: In this paper, N-isopropylacrylamide (NIPAAm) and methacrylic acid (MAA) were chosen for the temperature and pH-dependent swelling characteristics of their polymers, respectively.
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Uptake and function of membrane-destabilizing cationic nanogels for intracellular drug delivery
TL;DR: The obtained results suggest that the incorporation of hydrophobic monomers decreases the cytotoxicity of the nanogels to epithelial colorectal adenocarcinoma cells, and provide new insights of the potential of polymeric nanoformulations for intracellular delivery.