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Nina Le Bert
Researcher at National University of Singapore
Publications - 54
Citations - 5094
Nina Le Bert is an academic researcher from National University of Singapore. The author has contributed to research in topics: Medicine & Immune system. The author has an hindex of 18, co-authored 38 publications receiving 2170 citations. Previous affiliations of Nina Le Bert include Centre for Life & Agency for Science, Technology and Research.
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Journal ArticleDOI
SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls.
Nina Le Bert,Anthony T. Tan,Kamini Kunasegaran,Christine Y.L. Tham,Morteza Hafezi,Adeline Chia,Melissa Hui Yen Chng,Meiyin Lin,Meiyin Lin,Nicole Tan,Martin Linster,Wan Ni Chia,Mark I-Cheng Chen,Lin-Fa Wang,Eng Eong Ooi,Shirin Kalimuddin,Paul A. Tambyah,Jenny G. Low,Jenny G. Low,Yee-Joo Tan,Yee-Joo Tan,Antonio Bertoletti,Antonio Bertoletti +22 more
TL;DR: Infection with betacoronaviruses induces multi-specific and long-lasting T cell immunity against the structural N protein, and SARS-CoV-2-reactive T cells were found in individuals who had recovered from SARS or COVID-19 and in unexposed donors, although with different patterns of immunoreactivity.
Journal ArticleDOI
Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients.
Anthony T. Tan,Martin Linster,Chee Wah Tan,Nina Le Bert,Wan Ni Chia,Kamini Kunasegaran,Yan Zhuang,Christine Y.L. Tham,Adeline Chia,Gavin J. D. Smith,Barnaby Edward Young,Shirin Kalimuddin,Shirin Kalimuddin,Jenny G. Low,Jenny G. Low,David C. Lye,Lin-Fa Wang,Antonio Bertoletti,Antonio Bertoletti +18 more
TL;DR: In this article, the authors quantify SARS-CoV-2 viral RNA in the respiratory tract in parallel with antibodies and circulating T-cells specific for various structural (nucleoprotein [NP], membrane [M], ORF3a, and spike) and non-structural (ORF7/8, NSP7, and NSP13) proteins.
Journal ArticleDOI
Dynamics of SARS-CoV-2 neutralising antibody responses and duration of immunity: a longitudinal study.
Wan Ni Chia,Feng Zhu,Sean Wei Xiang Ong,Barnaby Edward Young,Barnaby Edward Young,Siew-Wai Fong,Nina Le Bert,Chee Wah Tan,Charles Tiu,Jinyan Zhang,Seow Yen Tan,Surinder Pada,Yi Hao Chan,Christine Y.L. Tham,Kamini Kunasegaran,Mark I-Cheng Chen,Jenny G. Low,Jenny G. Low,Yee Sin Leo,Laurent Rénia,Antonio Bertoletti,Lisa F. P. Ng,David C. Lye,Lin-Fa Wang +23 more
TL;DR: In this paper, the authors investigated the peak levels and dynamics of neutralising antibody waning and IgG avidity maturation over time, and correlate this with clinical parameters, cytokines, and T-cell responses.
Journal ArticleDOI
Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2.
Leo Swadling,Mariana O. Diniz,Nathalie M. Schmidt,Oliver E. Amin,Aneesh Chandran,Emily Shaw,Corinna Pade,Joseph M Gibbons,Nina Le Bert,Anthony T. Tan,Anna Jeffery-Smith,Anna Jeffery-Smith,Cedric C.S. Tan,Christine Y.L. Tham,Stephanie Kucykowicz,Gloryanne Aidoo-Micah,Joshua Rosenheim,Jessica Davies,Marina Johnson,Melanie P. Jensen,Melanie P. Jensen,George Joy,George Joy,Laura E. McCoy,Ana M. Valdes,Ana M. Valdes,Benjamin M. Chain,David Goldblatt,Daniel M. Altmann,Rosemary J. Boyton,Rosemary J. Boyton,Charlotte Manisty,Charlotte Manisty,Thomas A. Treibel,Thomas A. Treibel,James C. Moon,James C. Moon,Lucy van Dorp,Francois Balloux,Áine McKnight,Mahdad Noursadeghi,Antonio Bertoletti,Antonio Bertoletti,Mala K. Maini +43 more
TL;DR: In this paper, the authors measured SARS-CoV-2-reactive T-cells, including those against the early transcribed replication transcription complex (RTC) in intensively monitored healthcare workers (HCW), remaining repeatedly negative by PCR, antibody binding, and neutralization (seronegative HCW, SN-HCW).
Journal ArticleDOI
Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection.
Nina Le Bert,Hannah E. Clapham,Anthony T. Tan,Wan Ni Chia,Christine Y.L. Tham,Jane Mingjie Lim,Kamini Kunasegaran,Linda Wei Lin Tan,Charles-Antoine Dutertre,Nivedita Shankar,Joey M.E. Lim,Louisa Jin Sun,Marina Zahari,Zaw Myo Tun,Vishakha Kumar,Beng Lee Lim,Siew Hoon Lim,Adeline Chia,Yee-Joo Tan,Yee-Joo Tan,Paul A. Tambyah,Shirin Kalimuddin,Shirin Kalimuddin,David C. Lye,Jenny G. Low,Jenny G. Low,Lin-Fa Wang,Wei Yee Wan,Li Yang Hsu,Antonio Bertoletti,Antonio Bertoletti,Clarence C. Tam,Clarence C. Tam +32 more
TL;DR: In this article, SARS-CoV-2-specific T cells in a cohort of asymptomatic and symptomatic COVID-19 patients after seroconversion were longitudinally studied.