O
Olaf Ansorge
Researcher at University of Oxford
Publications - 9
Citations - 1465
Olaf Ansorge is an academic researcher from University of Oxford. The author has contributed to research in topics: Dementia with Lewy bodies & Genome-wide association study. The author has an hindex of 8, co-authored 9 publications receiving 1264 citations. Previous affiliations of Olaf Ansorge include John Radcliffe Hospital.
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Journal ArticleDOI
Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study
Elisa Majounie,Alan E. Renton,Kin Y. Mok,Elise G.P. Dopper,Elise G.P. Dopper,Adrian James Waite,Sara Rollinson,Adriano Chiò,Gabriella Restagno,Nayia Nicolaou,Nayia Nicolaou,Javier Simón-Sánchez,Javier Simón-Sánchez,John C. van Swieten,John C. van Swieten,Yevgeniya Abramzon,Janel O. Johnson,Michael Sendtner,Roger Pamphlett,Richard W. Orrell,Simon Mead,Katie C. L. Sidle,Henry Houlden,Jonathan D. Rohrer,Karen E. Morrison,Hardev Pall,Kevin Talbot,Olaf Ansorge,Dena G. Hernandez,Sampath Arepalli,Mario Sabatelli,Gabriele Mora,Massimo Corbo,Fabio Giannini,Andrea Calvo,Elisabet Englund,Giuseppe Borghero,Gian Luca Floris,Anne M. Remes,Hannu Laaksovirta,Leo McCluskey,John Q. Trojanowski,Vivianna M. Van Deerlin,Gerard D. Schellenberg,Mike A. Nalls,Vivian E. Drory,Chin-Song Lu,Chin-Song Lu,Tu-Hsueh Yeh,Tu-Hsueh Yeh,Hiroyuki Ishiura,Yuji Takahashi,Shoji Tsuji,Isabelle Le Ber,Isabelle Le Ber,Isabelle Le Ber,Alexis Brice,Alexis Brice,Alexis Brice,Carsten Drepper,Nigel Williams,Janine Kirby,Pamela J. Shaw,John Hardy,Pentti J. Tienari,Peter Heutink,Huw R. Morris,Huw R. Morris,Huw R. Morris,Stuart Pickering-Brown,Bryan J. Traynor,Bryan J. Traynor +71 more
TL;DR: A common Mendelian genetic lesion in C9orf72 is implicated in many cases of sporadic and familial ALS and FTD, suggesting a one-off expansion occurring about 1500 years ago.
Journal ArticleDOI
Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of Dementia with Lewy Bodies.
Jose Bras,Rita Guerreiro,Lee Darwent,Laura Parkkinen,Olaf Ansorge,Valentina Escott-Price,Dena G. Hernandez,Mike A. Nalls,Lorraine N. Clark,Lawrence S. Honig,Karen Marder,Wiesje M. van der Flier,Afina W. Lemstra,Philip Scheltens,Ekaterina Rogaeva,Peter St George-Hyslop,Peter St George-Hyslop,Elisabet Londos,Henrik Zetterberg,Sara Ortega-Cubero,Sara Ortega-Cubero,Pau Pastor,Pau Pastor,Tanis J. Ferman,Neill R. Graff-Radford,Owen A. Ross,Imelda Barber,Anne Braae,Kristelle Brown,Kevin Morgan,Walter Maetzler,Daniela Berg,Claire Troakes,Safa Al-Sarraj,Tammaryn Lashley,Yaroslau Compta,Tamas Revesz,Andrew J. Lees,Nigel J. Cairns,Glenda M. Halliday,Glenda M. Halliday,David M. A. Mann,Stuart Pickering-Brown,Dennis W. Dickson,Andrew B. Singleton,John Hardy +45 more
TL;DR: It is indicated that DLB has a unique genetic risk profile when compared with the two most common neurodegenerative diseases and that the lysosome may play an important role in the etiology of this disorder.
Journal ArticleDOI
Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study
Rita Guerreiro,Rita Guerreiro,Owen A. Ross,Celia Kun-Rodrigues,Dena G. Hernandez,Dena G. Hernandez,Tatiana Orme,John D. Eicher,Claire E. Shepherd,Claire E. Shepherd,Laura Parkkinen,Lee Darwent,Michael G. Heckman,Sonja W. Scholz,Juan C. Troncoso,Olga Pletnikova,Olaf Ansorge,Jordi Clarimón,Alberto Lleó,Estrella Morenas-Rodríguez,Lorraine N. Clark,Lawrence S. Honig,Karen Marder,Afina W. Lemstra,Ekaterina Rogaeva,Peter St George-Hyslop,Peter St George-Hyslop,Elisabet Londos,Henrik Zetterberg,Henrik Zetterberg,Henrik Zetterberg,Imelda Barber,Anne Braae,Kristelle Brown,Kevin Morgan,Claire Troakes,Safa Al-Sarraj,Tammaryn Lashley,Janice L. Holton,Yaroslau Compta,Yaroslau Compta,Vivianna M. Van Deerlin,Geidy E. Serrano,Thomas G. Beach,Suzanne Lesage,Douglas Galasko,Douglas Galasko,Eliezer Masliah,Isabel Santana,Pau Pastor,Pau Pastor,Monica Diez-Fairen,Monica Diez-Fairen,Miquel Aguilar,Miquel Aguilar,Pentti J. Tienari,Liisa Myllykangas,Minna Oinas,Tamas Revesz,Andrew J. Lees,Brad F. Boeve,Ronald C. Petersen,Tanis J. Ferman,Valentina Escott-Price,Neill R. Graff-Radford,Nigel J. Cairns,John C. Morris,Stuart Pickering-Brown,David M. A. Mann,Glenda M. Halliday,Glenda M. Halliday,Glenda M. Halliday,John Hardy,John Q. Trojanowski,Dennis W. Dickson,Andrew B. Singleton,David J. Stone,Jose Bras,Jose Bras +78 more
TL;DR: Despite the small sample size for a genome-wide association study, and acknowledging the potential biases from ascertaining samples from multiple locations, this study presents the most comprehensive and well powered genetic study in dementia with Lewy bodies so far.
Journal ArticleDOI
Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases
Rita Guerreiro,Valentina Escott-Price,Lee Darwent,Laura Parkkinen,Olaf Ansorge,Dena G. Hernandez,Mike A. Nalls,Lorraine N. Clark,Lawrence S. Honig,Karen Marder,Wiesje M. van der Flier,Henne Holstege,Eva Louwersheimer,Afina W. Lemstra,Philip Scheltens,Ekaterina Rogaeva,Peter St George-Hyslop,Peter St George-Hyslop,Elisabet Londos,Henrik Zetterberg,Sara Ortega-Cubero,Sara Ortega-Cubero,Pau Pastor,Pau Pastor,Pau Pastor,Tanis J. Ferman,Neill R. Graff-Radford,Owen A. Ross,Imelda Barber,Anne Braae,Kristelle Brown,Kevin Morgan,Walter Maetzler,Daniela Berg,Claire Troakes,Safa Al-Sarraj,Tammaryn Lashley,Yaroslau Compta,Yaroslau Compta,Tamas Revesz,Andrew J. Lees,Nigel J. Cairns,Glenda M. Halliday,David M. A. Mann,Stuart Pickering-Brown,John Powell,Katie Lunnon,Michelle K. Lupton,Dennis W. Dickson,John Hardy,Andrew B. Singleton,Jose Bras +51 more
TL;DR: Having shown that DLB shares some genetic risk with PD and AD, the amount of sharing is quantified through the application of genetic correlation estimates and it is shown that, from a purely genetic perspective, DLB is equally correlated to AD and PD.
Journal ArticleDOI
Analysis of neurodegenerative disease-causing genes in dementia with Lewy bodies
Tatiana Orme,Dena G. Hernandez,Owen A. Ross,Celia Kun-Rodrigues,Lee Darwent,Claire E. Shepherd,Laura Parkkinen,Olaf Ansorge,Lorraine N. Clark,Lawrence S. Honig,Karen Marder,Afina W. Lemstra,Ekaterina Rogaeva,Peter St George-Hyslop,Elisabet Londos,Henrik Zetterberg,Henrik Zetterberg,Kevin Morgan,Claire Troakes,Safa Al-Sarraj,Tammaryn Lashley,Janice L. Holton,Yaroslau Compta,Yaroslau Compta,Vivianna M. Van Deerlin,John Q. Trojanowski,Geidy E. Serrano,Thomas G. Beach,Suzanne Lesage,Douglas Galasko,Eliezer Masliah,Isabel Santana,Pau Pastor,Pentti J. Tienari,Liisa Myllykangas,Minna Oinas,Tamas Revesz,Andrew J. Lees,Brad F. Boeve,Ronald C. Petersen,Tanis J. Ferman,Valentina Escott-Price,Neill R. Graff-Radford,Nigel J. Cairns,John C. Morris,Stuart Pickering-Brown,David M. A. Mann,Glenda M. Halliday,David J. Stone,Dennis W. Dickson,John Hardy,Andrew B. Singleton,Rita Guerreiro,Jose Bras +53 more
TL;DR: The rarity of previously reported pathogenic mutations in this cohort suggests that the genetic overlap of other neurodegenerative diseases with DLB is not substantial, and suggests that other genetic loci play a role in this disease.