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Paul A. De Sousa

Researcher at University of Edinburgh

Publications -  62
Citations -  3039

Paul A. De Sousa is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Stem cell & Embryonic stem cell. The author has an hindex of 28, co-authored 62 publications receiving 2864 citations. Previous affiliations of Paul A. De Sousa include The Roslin Institute & University of Western Ontario.

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Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage

Katherine Amps, +124 more
- 27 Nov 2011 - 
TL;DR: Of these genes, BCL2L1 is a strong candidate for driving culture adaptation of ES cells, and single-nucleotide polymorphism analysis revealed that they included representatives of most major ethnic groups.
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Evaluation of gestational deficiencies in cloned sheep fetuses and placentae.

TL;DR: It is demonstrated that within the first quarter of gestation, cloned fetuses are characterized by a high incidence of developmental retardation and placental insufficiency, not linked to gross defects in chromosome number.
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Lineage-specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development.

TL;DR: 5-hmC represents the first epigenetic modification of DNA discovered whose enrichment is so cell-type specific and correlates with a pluripotent cell state, and is suggested to be an epigenetic feature of embryonic cell populations and cellular pluri- and multi-lineage potency.
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Somatic Cell Nuclear Transfer in the Pig: Control of Pronuclear Formation and Integration with Improved Methods for Activation and Maintenance of Pregnancy

TL;DR: A 2-h delay between electrical fusion and activation yielded blastocysts more reliably and with a higher nuclear count than did SA, and inclusion of a microtubule inhibitor such as nocodozole with CB before and after DA improved nuclear retention and favored the formation of single pronuclei in experiments using a membrane dye to reliably monitor fusion.
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Dielectrophoresis: A Review of Applications for Stem Cell Research

TL;DR: This review summarises the properties of cells that contribute to their dielectrophoretic behaviour, and their relevance to stem cell research and translational applications.