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Paul A. De Sousa
Researcher at University of Edinburgh
Publications - 62
Citations - 3039
Paul A. De Sousa is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Stem cell & Embryonic stem cell. The author has an hindex of 28, co-authored 62 publications receiving 2864 citations. Previous affiliations of Paul A. De Sousa include The Roslin Institute & University of Western Ontario.
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Journal ArticleDOI
Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage
Katherine Amps,Peter W. Andrews,George Anyfantis,Lyle Armstrong,Stuart Avery,Hossein Baharvand,Julie C. Baker,Duncan Baker,Maria D. Barbadillo Muñoz,Stephen J. Beil,Nissim Benvenisty,Dalit Ben-Yosef,Juan Carlos Biancotti,Alexis Bosman,Romulo M. Brena,Daniel R. Brison,Gunilla Caisander,Marãa V. Camarasa,Jieming Chen,Eric Chiao,Young Min Choi,Andre Choo,D.M. Collins,Alan Colman,Jeremy M. Crook,George Q. Daley,Anne Dalton,Paul A. De Sousa,Chris Denning,J.M. Downie,Petr Dvorak,Karen Dyer Montgomery,Anis Feki,Angela Ford,Victoria Fox,Ana Maria Fraga,Tzvia Frumkin,Lin Ge,Paul J. Gokhale,Tamar Golan-Lev,Hamid Gourabi,Michal Gropp,Lu GuangXiu,Aleš Hampl,Katie Harron,Lyn Healy,Wishva Herath,Frida Holm,Outi Hovatta,Johan Hyllner,Maneesha S. Inamdar,Astrid K. Irwanto,Tetsuya Ishii,Marisa Jaconi,Ying Jin,Susan J. Kimber,Sergey Kiselev,Barbara B. Knowles,Oded Kopper,Valeri Kukharenko,Anver Kuliev,Maria A. Lagarkova,Peter W. Laird,Majlinda Lako,Andrew L. Laslett,Neta Lavon,Dong Ryul Lee,Jeoung Eun Lee,Chunliang Li,Linda S. Lim,Tenneille Ludwig,Yu Ma,Edna Maltby,Ileana Mateizel,Yoav Mayshar,Maria Mileikovsky,Stephen L. Minger,Takamichi Miyazaki,Shin Yong Moon,Harry Moore,Christine L. Mummery,Andras Nagy,Norio Nakatsuji,Kavita Narwani,Steve Oh,Sun Kyung Oh,Cia Olson,Timo Otonkoski,Fei Pan,In-Hyun Park,Steve Pells,Martin F. Pera,Lygia da Veiga Pereira,Ouyang Qi,Grace Selva Raj,Benjamin Reubinoff,Alan Robins,Paul Robson,Janet Rossant,Ghasem Hosseini Salekdeh,Thomas C. Schulz,Karen Sermon,Jameelah Sheik Mohamed,Hui Shen,Eric S Sherrer,Kuldip S. Sidhu,Shirani Sivarajah,Heli Skottman,Claudia Spits,Glyn Stacey,Raimund Strehl,Nick Strelchenko,Hirofumi Suemori,Bowen Sun,Riitta Suuronen,Kazutoshi Takahashi,Timo Tuuri,Parvathy Venu,Yuri Verlinsky,Dorien Ward-van Oostwaard,Daniel J. Weisenberger,Yue Wu,Shinya Yamanaka,Lorraine E. Young,Qi Zhou +124 more
TL;DR: Of these genes, BCL2L1 is a strong candidate for driving culture adaptation of ES cells, and single-nucleotide polymorphism analysis revealed that they included representatives of most major ethnic groups.
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Evaluation of gestational deficiencies in cloned sheep fetuses and placentae.
TL;DR: It is demonstrated that within the first quarter of gestation, cloned fetuses are characterized by a high incidence of developmental retardation and placental insufficiency, not linked to gross defects in chromosome number.
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Lineage-specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development.
Alexey Ruzov,Alexey Ruzov,Yanina Tsenkina,Andrea Serio,Tatiana Dudnakova,Judy Fletcher,Yu Bai,Tatiana Chebotareva,Steve Pells,Zara Hannoun,Gareth J. Sullivan,Siddharthan Chandran,David C. Hay,Mark Bradley,Ian Wilmut,Paul A. De Sousa +15 more
TL;DR: 5-hmC represents the first epigenetic modification of DNA discovered whose enrichment is so cell-type specific and correlates with a pluripotent cell state, and is suggested to be an epigenetic feature of embryonic cell populations and cellular pluri- and multi-lineage potency.
Journal ArticleDOI
Somatic Cell Nuclear Transfer in the Pig: Control of Pronuclear Formation and Integration with Improved Methods for Activation and Maintenance of Pregnancy
Paul A. De Sousa,J.R. Dobrinsky,Jie Zhu,Alan Archibald,Alison Ainslie,Wim Bosma,June Bowering,John Bracken,Patricia M. Ferrier,Judy Fletcher,Bianca Gasparrini,Linda Harkness,Paul Johnston,Marjorie Ritchie,W. A. Ritchie,Ailsa Travers,David F. Albertini,Andras Dinnyes,Tim King,Ian Wilmut +19 more
TL;DR: A 2-h delay between electrical fusion and activation yielded blastocysts more reliably and with a higher nuclear count than did SA, and inclusion of a microtubule inhibitor such as nocodozole with CB before and after DA improved nuclear retention and favored the formation of single pronuclei in experiments using a membrane dye to reliably monitor fusion.
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Dielectrophoresis: A Review of Applications for Stem Cell Research
TL;DR: This review summarises the properties of cells that contribute to their dielectrophoretic behaviour, and their relevance to stem cell research and translational applications.