Karen Dyer Montgomery

TL;DR: Of these genes, BCL2L1 is a strong candidate for driving culture adaptation of ES cells, and single-nucleotide polymorphism analysis revealed that they included representatives of most major ethnic groups.

TL;DR: The data show that the recurrent chromosome abnormalities in human ESC and iPSC cultures are similar to each other and distinct from those reported in embryos, both in frequency and in type.

TL;DR: It is demonstrated that iPSCs free of transgene and vector sequences could be generated from human BM and CB mononuclear cells using non-integrating episomal vectors and showed a unique complex chromosomal translocation identified in marrow sample while displaying typical embryonic stem cell phenotype and pluripotent differentiation potential.

TL;DR: The American public has five distinct attitudes toward (i) cloning animals, (ii) cloning humans, (iii) curing serious diseases by therapeutic cloning or by using stem cells from an IVF embryo, (iv) curingserious diseases using adult stem cells and (v) using any of these for cosmetic purposes.

TL;DR: It is confirmed that iPS cells themselves may carry a significant mutational load at initial isolation, but that the clonal events and prolonged cultured required for correction of a genetic defect can be accomplished without a substantial increase in mutational burden.