Yue Wu

TL;DR: Of these genes, BCL2L1 is a strong candidate for driving culture adaptation of ES cells, and single-nucleotide polymorphism analysis revealed that they included representatives of most major ethnic groups.

TL;DR: These data demonstrate that the AT1 is expressed by beta cells and that angiotensin II effects a short-lived and direct stimulation of human and mouse beta cells to promote insulin secretion, most probably through elevations in intracellular calcium.

TL;DR: C coculture of human hepatocytes with MSCs demonstrates both improved function and viability, and such coculture conditions may convey major advantages in hepatocyte survival and function for cell transplantation.

TL;DR: It is shown that stimulation of RARα is required for the differentiation of OPCs and described for the first time how oral treatment with a RARβ agonist leads to the endogenous synthesis of RA through retinaldehyde dehydrogenase 2 in NG2 cells and controls exosome-associated-RA intracellular levels through a decorin–Ca2+ pathway.

TL;DR: A novel mechanism by which neuronal RARβ activation results in the endogenous synthesis of RA which is released in association with exosomes and acts as a positive cue to axonal/neurite outgrowth.