Tamar Golan-Lev

TL;DR: Of these genes, BCL2L1 is a strong candidate for driving culture adaptation of ES cells, and single-nucleotide polymorphism analysis revealed that they included representatives of most major ethnic groups.

TL;DR: Cellular and molecular analyses demonstrated that the most selective compound, PluriSIn #1, induces ER stress, protein synthesis attenuation, and apoptosis in hPSCs and prevented teratoma formation from tumorigenic undifferentiated cells.

TL;DR: It is suggested that continued expression of survivin upon differentiation in vivo may contribute to teratoma formation by hES cells and may help elucidate the basic principles of tumor initiation.

TL;DR: Comparison of proliferation, differentiation and apoptosis between diploid and aneuploid hPSC shows that trisomy 12 significantly increases the proliferation rate of hPSCs, mainly as a consequence of increased replication.

TL;DR: Haploid human embryonic stem cells have been found to be compatible with the undifferentiated pluripotent state and differentiated somatic fates in vitro and in vivo, despite a persistent dosage imbalance between the autosomes and X chromosome as discussed by the authors.