P
Paule Opolon
Researcher at Institut Gustave Roussy
Publications - 171
Citations - 18425
Paule Opolon is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Angiogenesis & Cancer. The author has an hindex of 54, co-authored 168 publications receiving 15233 citations. Previous affiliations of Paule Opolon include Université Paris-Saclay & French Institute of Health and Medical Research.
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Journal ArticleDOI
Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors
Bertrand Routy,Bertrand Routy,Bertrand Routy,Lisa Derosa,Lisa Derosa,Lisa Derosa,Connie P.M. Duong,Connie P.M. Duong,Maryam Tidjani Alou,Maryam Tidjani Alou,Maryam Tidjani Alou,Romain Daillère,Romain Daillère,Romain Daillère,Aurélie Fluckiger,Aurélie Fluckiger,Meriem Messaoudene,Meriem Messaoudene,Conrad Rauber,Conrad Rauber,Conrad Rauber,Maria Paula Roberti,Maria Paula Roberti,Marine Fidelle,Marine Fidelle,Caroline Flament,Caroline Flament,Vichnou Poirier-Colame,Vichnou Poirier-Colame,Paule Opolon,Christophe Klein,Kristina Iribarren,Laura Mondragón,Nicolas Jacquelot,Nicolas Jacquelot,Nicolas Jacquelot,Bo Qu,Bo Qu,Bo Qu,Gladys Ferrere,Gladys Ferrere,Gladys Ferrere,Céline Clémenson,Céline Clémenson,Laura Mezquita,Jordi Remon Masip,C. Naltet,Solenn Brosseau,Coureche Kaderbhai,Corentin Richard,Hira Rizvi,Florence Levenez,Nathalie Galleron,Benoit Quinquis,Nicolas Pons,Bernhard Ryffel,Veronique Minard-Colin,Patrick Gonin,Jean-Charles Soria,Eric Deutsch,Eric Deutsch,Yohann Loriot,Yohann Loriot,François Ghiringhelli,Gérard Zalcman,François Goldwasser,B. Escudier,B. Escudier,Matthew D. Hellmann,Matthew D. Hellmann,Alexander M.M. Eggermont,Alexander M.M. Eggermont,Didier Raoult,Laurence Albiges,Laurence Albiges,Guido Kroemer,Laurence Zitvogel +76 more
TL;DR: It is found that primary resistance to ICIs can be attributed to abnormal gut microbiome composition, and Antibiotics inhibited the clinical benefit of ICIs in patients with advanced cancer.
Journal ArticleDOI
Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota
Marie Vétizou,Marie Vétizou,Marie Vétizou,Jonathan M. Pitt,Jonathan M. Pitt,Jonathan M. Pitt,Romain Daillère,Romain Daillère,Romain Daillère,Patricia Lepage,Nadine Waldschmitt,Caroline Flament,Caroline Flament,Sylvie Rusakiewicz,Sylvie Rusakiewicz,Bertrand Routy,Maria Paula Roberti,Maria Paula Roberti,Connie P.M. Duong,Connie P.M. Duong,Vichnou Poirier-Colame,Vichnou Poirier-Colame,Antoine Roux,Antoine Roux,Antoine Roux,Sonia Becharef,Sonia Becharef,Silvia C. Formenti,Encouse B. Golden,Sascha Cording,Gérard Eberl,Andreas Schlitzer,Florent Ginhoux,Sridhar Mani,Takahiro Yamazaki,Takahiro Yamazaki,Nicolas Jacquelot,Nicolas Jacquelot,Nicolas Jacquelot,David Enot,David Enot,Marion Bérard,Jérôme Nigou,Jérôme Nigou,Paule Opolon,Alexander M.M. Eggermont,Alexander M.M. Eggermont,Paul Louis Woerther,Elisabeth Chachaty,Nathalie Chaput,Nathalie Chaput,Caroline Robert,Caroline Robert,Christina Mateus,Guido Kroemer,Didier Raoult,Ivo G. Boneca,Ivo G. Boneca,Franck Carbonnel,Mathias Chamaillard,Laurence Zitvogel +60 more
TL;DR: A key role is revealed for Bacteroidales in the immunostimulatory effects of CTLA-4 blockade, which is found to depend on distinct Bacteroides species in mice and patients.
Journal ArticleDOI
The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide
Sophie Viaud,Sophie Viaud,Fabiana Saccheri,Grégoire Mignot,Takahiro Yamazaki,Romain Daillère,Romain Daillère,Dalil Hannani,David Enot,David Enot,Christina Pfirschke,Camilla Engblom,Mikael J. Pittet,Andreas Schlitzer,Florent Ginhoux,Lionel Apetoh,Elisabeth Chachaty,Paul Louis Woerther,Gérard Eberl,Marion Bérard,Chantal Ecobichon,Chantal Ecobichon,Dominique Clermont,Chantal Bizet,Valérie Gaboriau-Routhiau,Valérie Gaboriau-Routhiau,Nadine Cerf-Bensussan,Nadine Cerf-Bensussan,Paule Opolon,Nadia Yessaad,Eric Vivier,Bernhard Ryffel,Charles O. Elson,Joël Doré,Joël Doré,Guido Kroemer,Patricia Lepage,Patricia Lepage,Ivo G. Boneca,Ivo G. Boneca,François Ghiringhelli,François Ghiringhelli,Laurence Zitvogel,Laurence Zitvogel,Laurence Zitvogel +44 more
TL;DR: It is demonstrated that cyclophosphamide alters the composition of microbiota in the small intestine and induces the translocation of selected species of Gram-positive bacteria into secondary lymphoid organs, which suggests that the gut microbiota help shape the anticancer immune response.
Journal ArticleDOI
TET2 Inactivation Results in Pleiotropic Hematopoietic Abnormalities in Mouse and Is a Recurrent Event during Human Lymphomagenesis
Cyril Quivoron,Cyril Quivoron,Cyril Quivoron,Lucile Couronné,Lucile Couronné,Lucile Couronné,Véronique Della Valle,Véronique Della Valle,Véronique Della Valle,Cécile K. Lopez,Cécile K. Lopez,Cécile K. Lopez,Isabelle Plo,Isabelle Plo,Isabelle Plo,Orianne Wagner-Ballon,Marcio Do Cruzeiro,François Delhommeau,François Delhommeau,Bertrand Arnulf,Marc-Henri Stern,Lucy A. Godley,Paule Opolon,Hervé Tilly,Eric Solary,Eric Solary,Eric Solary,Yannis Duffourd,Philippe Dessen,Philippe Dessen,Philippe Dessen,Hélène Merle-Béral,Florence Nguyen-Khac,Michaela Fontenay,William Vainchenker,William Vainchenker,William Vainchenker,Christian Bastard,Thomas Mercher,Thomas Mercher,Thomas Mercher,Olivier Bernard,Olivier Bernard,Olivier Bernard +43 more
TL;DR: It is reported that inactivation of Tet2 in mouse perturbs both early and late steps of hematopoiesis including myeloid and lymphoid differentiation in a cell-autonomous manner, endows the cells with competitive advantage, and eventually leads to the development of malignancies.
Journal ArticleDOI
Comparison of antisense oligonucleotides and siRNAs in cell culture and in vivo.
Jean-Rémi Bertrand,Mireille Pottier,Antoine Vekris,Paule Opolon,Andrei Maksimenko,Claude Malvy +5 more
TL;DR: Using Cytofectin GSV to deliver both inhibitors, the siRNAs appear to be quantitatively more efficient and its effect is lasting for a longer time in cell culture and in mice, an activity of siRNA but not of antisense oligonucleotides is observed.